Formation of W/O Microemulsion Based on Natural Glycolipid Biosurfactant, Mannosylerythritol Lipid-A

Worakitkanchanakul, Wannasiri; Imura, Tomohiro; Morita, Tomotake; Fukuoka, Tokuma; Sakai, Hideki; Abe, Masahiko; Rujiravanit, Ratana; Chavadej, Sumaeth; Kitamoto, Daï

doi:10.5650/jos.57.55

Cited by 22 publications

(7 citation statements)

References 27 publications

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“…In a separate study, the glycolipid MEL-A synthesized by Pseudozyma antarctica was used to investigate the phase behavior of a ternary MEL-A/water/n-decane system [69]. The MEL-A-stabilized system formed a W/O microemulsion without the need for co-surfactants.…”

Section: Green Molecules In Drug Formulationmentioning

confidence: 99%

Potential therapeutic applications of biosurfactants

Gudiña

Rangarajan

Sen

et al. 2013

Trends in Pharmacological Sciences

312

194

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Biosurfactants have recently emerged as promising molecules for their structural novelty, versatility, and diverse properties that are potentially useful for many therapeutic applications. Mainly due to their surface activity, these molecules interact with cell membranes of several organisms and/or with the surrounding environments, and thus can be viewed as potential cancer therapeutics or as constituents of drug delivery systems. Some types of microbial surfactants, such as lipopeptides and glycolipids, have been shown to selectively inhibit the proliferation of cancer cells and to disrupt cell membranes causing their lysis through apoptosis pathways. Moreover, biosurfactants as drug delivery vehicles offer commercially attractive and scientifically novel applications. This review covers the current state-of-the-art in biosurfactant research for therapeutic purposes, providing new directions towards the discovery and development of molecules with novel structures and diverse functions for advanced applications.

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Section: Green Molecules In Drug Formulationmentioning

confidence: 99%

Potential therapeutic applications of biosurfactants

Gudiña

Rangarajan

Sen

et al. 2013

Trends in Pharmacological Sciences

312

194

View full text Add to dashboard Cite

show abstract

“…W/O (water and oil)] stabilized by appropriate surfactants. The formation of a W/O microemulsion of MEL‐A produced by P. antarctica was investigated using dynamic light scattering and freeze–fracture electron microscopy [63]. The W/O microemulsion by the addition of water to a MEL‐A/ n ‐decane mixture kept their single‐phase transparent appearance.…”

Section: Self‐assembling Properties Of Melsmentioning

confidence: 99%

Production of glycolipid biosurfactants by basidiomycetous yeasts

Morita

Fukuoka

Imura

et al. 2009

Biotech and App Biochem

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BSs (biosurfactants) produced by various micro-organisms show unique properties (e.g. mild production conditions, lower toxicity, higher biodegradability and environmental compatibility) compared with chemically synthesized surfactants. The numerous advantages of BSs have prompted applications not only in the food, cosmetic and pharmaceutical industries but also in environmental protection and energy-saving technology. Among BSs, glycolipid types are the most promising, owing to their high productivity from renewable resources and versatile biochemical properties. MELs (mannosylerythritol lipids), which are glycolipid BSs abundantly produced by basidiomycetous yeasts such as strains of Pseudozyma, exhibit not only excellent interfacial properties, but also remarkable differentiation-inducing activities against human leukaemia cells. MELs also show high binding affinity towards different immunoglobulins and lectins. Recently, a cationic liposome bearing MEL has been demonstrated to increase dramatically the efficiency of gene transfection into mammalian cells. These features of BSs should broaden their application in new advanced technologies. In the present review the current status of research and development on glycolipid BSs, especially their production by Pseudozyma yeasts, is described.

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“…It indicated that the emulsion system was water in oil (w/o) type. This system is similar to the emulsion system of a glycolipid type biosurfactant, Mannosylerythritol Lipid-A, from Pseudozyma antarctica which also forms water in oil (w/o) emulsions (Worakitkanchanakul et al 2008). Water in oil (w/o) type emulsions of surfactants can be used in various applications such as cosmetic formulations, foods such as salad dressings, food texture improvement, and low-fat creams (Sharma 2016).…”

Section: Characterization Of Biosurfactantsmentioning

confidence: 95%

Production and characterization of biosurfactant produced by Lactobacillus lactis grown in media containing Crude Palm Oil (CPO)

et al. 2021

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Biosurfactants are surface-active compounds produced by a wide variety of diverse microorganisms. The structural diversity of biosurfactants depends on microorganisms and growth conditions (such as substrate and pH). The unique structure of biosurfactants provides unique properties for specific applications. Biosurfactant production still needs to be explored using a variety of microorganisms and growth conditions for producing the diversity of biosurfactant structures. Production and characterization of biosurfactant by Lactobacillus lactis using Crude Palm Oil (CPO) as an additional carbon source has been conducted. The optimization condition of biosurfactant production by L. lactis using media containing various concentrations of CPO was evaluated. Optical density, surface tension, and emulsification index were observed daily for 12 days. Optimal biosurfactant production condition was achieved when L. lactis was grown on media Nutrient Broth containing 10% (v/v) of CPO and incubated for 8 days. Biosurfactants were obtained for 80 mg/L media. Based on Thin Layer Chromatography (TLC) analysis and Fourier Transform Infra-Red (FT-IR) Spectroscopy, produced biosurfactant was identified as a glycolipid biosurfactant containing functional groups of hydroxyl, ester, carboxylic, methyl, and methylene. Produced biosurfactants exhibited the Critical Micelle Concentration (CMC) value of 1 g/L with a surface tension value of 49.46 mN/m. The emulsion system of produced biosurfactant was water in oil (w/o). The produced biosurfactant showed an emulsification index of 41-71% with soybean oil, palm oil, sunflower oil, olive oil, and lubricant oil. The stable emulsion was reached up to 30 days when soybean oil, olive oil, and lubricant oil were used as the water-immiscible compound.

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Formation of W/O Microemulsion Based on Natural Glycolipid Biosurfactant, Mannosylerythritol Lipid-A

Cited by 22 publications

References 27 publications

Potential therapeutic applications of biosurfactants

Potential therapeutic applications of biosurfactants

Production of glycolipid biosurfactants by basidiomycetous yeasts

Production and characterization of biosurfactant produced by Lactobacillus lactis grown in media containing Crude Palm Oil (CPO)

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