Formation of toroids by self-assembly of an α–α corner mimetic: supramolecular cyclization

Podder, Debasish; Bera, Santu; Debnath, Mintu; Das, Tarun; Haldar, Debasish

doi:10.1039/c7tb01711a

Cited by 9 publications

(7 citation statements)

References 68 publications

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“…Haldar and colleague used a central nonchiral spacer to connect two tripeptide fragments with intrinsic 3 10 helical folding propensity stabilized by multiple intramolecular hydrogen bonds, thereby mimicking the α–α corner motif of a protein super secondary structure [ 55 ]. The peptidomimetic compound initially self-assembled to a rod-like supramolecular structure which latter converted to uniform toroids through end-to-end like cyclization reaction.…”

Section: Nanostructures Of Helical Peptides For Diverse Functional Apmentioning

confidence: 99%

Self-assembly of Functional Nanostructures by Short Helical Peptide Building Blocks

Bera

Gazit

2019

PPL

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The self-assembly of short peptide building blocks into well-ordered nanostructures is a key direction in bionanotechnology. The formation of β -sheet organizations by short peptides is well explored, leading to the development of a wide range of functional assemblies. Likewise, many natural proteinaceous materials, such as silk and amyloid fibrils, are based on β-sheet structures. In contrast, collagen, the most abundant protein in mammals, is based on helical arrangement. Similar to β-sheet structures, short helical peptides have been recently discovered to possess a diverse set of functionalities with the potential to fabricate artificial self-assembling materials. Here, we outline the functional roles of self-assembled nanostructures formed by short helical peptides and their potential as artificial materials. We focus on the association between self-assembled mesoscale structures and their material function and demonstrate the way by which this class of building blocks bears the potential for diverse applications, such as the future fabrication of smart devices.

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Section: Nanostructures Of Helical Peptides For Diverse Functional Apmentioning

confidence: 99%

Self-assembly of Functional Nanostructures by Short Helical Peptide Building Blocks

Bera

Gazit

2019

PPL

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“…This can be attributed to the nature of the self-assembly process. 21,36 A final number fraction of 66% toroid was determined by TEM. The toroids have a zeta potential ( ξ ) of −27.6 mV and dynamic light scattering (DLS) analysis shows that these nanostructures have a hydrodynamic diameter ( D h ) of approximately 304 nm (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…One peptide fragment consists of l -leucine, α-aminoisobutyric acid (Aib), and l -tyrosine; which forms rigid 3 10 helical structures, and two 3 10 helices to maintain an angular distance of 120° to mimic the α–α corner secondary structure. 21 However, peptide building blocks were designed using various amino acids to meet the complex driving forces and structural requirements. 21,22 Recently, ring-opening polymerization of N -carboxyanhydride (NCA) has been an important method to synthesize polypeptides that exhibit interesting self-assembly behaviours and applications.…”

Section: Introductionmentioning

confidence: 99%

“…21 However, peptide building blocks were designed using various amino acids to meet the complex driving forces and structural requirements. 21,22 Recently, ring-opening polymerization of N -carboxyanhydride (NCA) has been an important method to synthesize polypeptides that exhibit interesting self-assembly behaviours and applications. 23–29 Therefore, it is important to investigate the preparation of toroids from simple and biodegradable homopolypeptides that arise from NCA-polymerisations.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescent homopolypeptide toroids

et al. 2022

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“…As one of the most fascinating structures, polymeric toroids can be regarded as ring-shaped cylinders or hollow disks. Such toroidal nanostructures, including plasmid DNA, β-barrel-folded transmembrane protein, and circular RNA, are very important and have fundamental functionalities in organisms. − The study of toroidal-shaped nanostructures is very important for understanding many complex biological processes. Typically, polymeric toroids can be prepared by direct self-assembly, bending of nanorods, − twining of nanofibers, template-assisted self-assembly, etc.…”

mentioning

confidence: 99%

Polymeric Toroids Derived from the Fusion-Induced Particle Assembly of Anisotropic Bowl-Shaped Nanoparticles

Zhou

Gao

et al. 2023

ACS Macro Lett.

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Polymeric toroids are fascinating soft nanostructures due to their unique geometry and properties, which have shown potential applications in the fields of nanoreactors, drug delivery, cancer therapy, etc. However, facile preparation of polymeric toroids is still challenging. Herein, we propose a fusion-induced particle assembly (FIPA) strategy to prepare polymeric toroids using anisotropic bowl-shaped nanoparticles (BNPs) as a building block. The BNPs are prepared in ethanol by the self-assembly of an amphiphilic homopolymer, poly(N-(2,2′bipyridyl)-4-acrylamide) (PBPyAA), synthesized via reversible addition−fragmentation chain transfer (RAFT) polymerization. Upon incubation in ethanol above the glass transition temperature (T g ) of PBPyAA, the BNPs gradually aggregate to form trimers and tetramers due to the disturbance of the colloidal stability. With the increase in incubation time, the aggregated BNPs fuse with each other and then form toroids. Notably, we find that only anisotropic BNPs can aggregate and fuse to form toroids rather than spherical compound micelles due to high surface free energy and curvature at the edge of the BNPs. Besides, mathematical calculations further confirm the formation of trimers and tetramers during the FIPA process and the driving force for the formation of toroids. Overall, we propose a fresh insight for the facile preparation of polymeric toroids by the FIPA of anisotropic BNPs.

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Formation of toroids by self-assembly of an α–α corner mimetic: supramolecular cyclization

Abstract: An α–α corner mimetic self-assembles into a rod shape supramolecular structure which bends and closes end-to-end like a cyclization reaction to form toroids.

Cited by 9 publications

References 68 publications

Self-assembly of Functional Nanostructures by Short Helical Peptide Building Blocks

Self-assembly of Functional Nanostructures by Short Helical Peptide Building Blocks

Fluorescent homopolypeptide toroids

Polymeric Toroids Derived from the Fusion-Induced Particle Assembly of Anisotropic Bowl-Shaped Nanoparticles

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