Formation of the Neutron Energy Spectrum Near the Target of a Portable NG-24M Neutron Generator

Sevast'yanov, V. D.; Kovalenko, O. I.; Орлов, А. В.; Shibaev, R. M.; Obudovskii, S. Yu.; Portnov, D. V.; Batyunin, A. V.; Kashchuk, Yu. A.

doi:10.1007/s11018-016-1082-2

Cited by 2 publications

(1 citation statement)

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“…The nuclear reaction 3H(d,n) generates 14–15 MeV neutrons. Due to a big reaction cross section (5 barn at 107 keV), one can obtain a flux of >1011 neutrons/s [4, 5]. Theoretical calculations and experiments showed that the neutron energy (14.71–14.87 MeV) was practically linearly dependent on the accelerating voltage [6, 7].…”

Section: Introductionmentioning

confidence: 99%

A Unique Prototypic Device for Radiation Therapy: The p53-Independent Antiproliferative Effect of Neutron Radiation

Yurkov

Syromukov

Tatarskiy³

et al. 2019

Acta Naturae

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Radiation therapy with heavy particles including neutrons, an otherwise therapeutically perspective because of its high tissue penetration and efficient tumor damage, is currently limited by the lack of adequate equipment. An NG-24 generator (140 kg, 42 110 cm, ~1011 particles/s, 14 MeV) has been designed and engineered to replace the huge and environmentally harmful neutron reactors, cyclotrons, and accelerators with a compact, portable, safe, and potent source of high-energy neutrons. We demonstrate that the neutron beam produced by NG-24 causes a significant antiproliferative effect on human tumor cell lines regardless of the status of the anti-apoptotic p53 protein. Phosphorylation of histone 2A and increased amounts of p21, cyclin D, and phospho-p53 were detectable in HCT116 colon carcinoma cells (wild-type p53) irradiated with 4 Gy several days post-treatment, accompanied by G2/M phase arrest. These treatments dramatically reduced the ability of single cells to form colonies. In the HCT116p53KO subline (p53 -/-), the G2/M arrest was independent of the aforementioned mechanisms. Hence, the NG-24 generator is a source of a powerful, therapeutically relevant neutron flux that triggers a p53-independent antiproliferative response in tumor cells.

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Section: Introductionmentioning

confidence: 99%