Formation of striatum structural and ultrastructural organization in rat postnatal ontogenesis at changes of conditions of their embryonic development

Журавин, И. А.; Туманова, Н. Л.; Ozirskaya, E. V.; Vasiliev, D. S.; Dubrovskaya, N. М.

doi:10.1134/s0022093007020123

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…In the course of normal metabolic reactions, active forms of oxygen are formed in the cells and their amount greatly increases during hypoxia [2]. Brain is hypersensitive to hypoxia [4,5]. A lot of enzymes are affected by hypoxia [6].…”

Section: Issn-e: 2148-6905 /© Ijsm 2018mentioning

confidence: 99%

Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain

Rashidova¹

2018

International Journal of Secondary Metabolite

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The effect of hypoxic hypoxia on the pyruvate kinase (PK) activity in the brain structures of white rats during ontogenesis in a comparative aspect has been studied. A clear dependence could be established in the increase of PK activity from an oxygen deficient state, the age of animals, the studied structure of the brain and the prolonged effect of hypoxia. Prenatal exposure to hypoxia has shown that the PK activity is not restored to the control value level in postnatal development. After postnatal exposure to hypoxia with increasing age in animals, the PK activity gets more resistant to the effect of stress-factors. The data analysis indicates that the increasing exhaustion of energy resources necessary for normal cell functioning makes an important contribution to the development of hypoxic state and the insufficiency of mitochondrial oxidative phosphorylation, the main energy forming system which underlies these disturbances. Energy-shortage, in its turn causes a variety of secondary negative metabolic alterations and gives rise to free radical oxidation in the cells. An explanation of the obtained results suggested can be considered as an evidence of the realization of the biological effect of hypoxia through the oxidative mechanism.

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Section: Issn-e: 2148-6905 /© Ijsm 2018mentioning

confidence: 99%

Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain

Rashidova¹

2018

International Journal of Secondary Metabolite

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Ultrastructural Alterations in the Sensorimotor Cortex upon Delayed Development of Motor Behavior in Early Ontogenesis of Rats Exposed to Prenatal Hypoxia

et al. 2018

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Age-Dependent Electrocorticogram Dynamics and Epileptogenic Responsiveness in Rats Subjected to Prenatal Hypoxia

et al. 2019

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Using electrocorticogram (ECoG) analysis, we compared age-related dynamics of general neuronal activity and convulsive epileptiform responsiveness induced by intracortical microinjections of 4-aminopyridine (4-AP) in control Wistar rats and those subjected to prenatal hypoxia (Hx; E14; 7% O2, 3 h). The studies were carried out in three age periods roughly corresponding to childhood (P20–27), adolescence (P30–45), and adulthood (P90–120). It was found that in the process of postnatal development of the control rats, the peak of the ECoG power spectrum density (PSD) of the theta rhythm during wakefulness shifted from the low to the higher frequency, while in the Hx rats this shift had the opposite direction. Moreover, the Hx rats had different frequency characteristics of the ECoG PSD and longer episodes of spike-and-wave discharges caused by 4-AP injections compared to the controls. The total ECoG PSD of slow-wave sleep (1–5 Hz) was also dramatically decreased in the process of development of the Hx rats. Such alterations in PSD could be explained by the changes in balance of the excitation and inhibition processes in the cortical networks. Analyzing protein levels of neurotransmitter transporters in the brain structures of the Hx rats, we found that the content of the glutamate transporter EAAT1 was higher in the parietal cortex in all age groups of Hx rats while in the hippocampus it decreased during postnatal development compared to controls. Furthermore, the content of the vesicular acetylcholine transporter in the parietal cortex, and of the inhibitory GABA transporter 1 in the hippocampus, was also affected by prenatal Hx. These data suggest that prenatal Hx results in a shift in the excitatory and inhibitory balance in the rat cortex towards excitation, making the rat’s brain more vulnerable to the effects of proconvulsant drugs and predisposing animals to epileptogenesis during postnatal life.

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Formation of striatum structural and ultrastructural organization in rat postnatal ontogenesis at changes of conditions of their embryonic development

Cited by 3 publications

References 13 publications

Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain

Effect of Pre-/ Postnatal Hypoxia on Pyruvate Kinase in Rat Brain

Ultrastructural Alterations in the Sensorimotor Cortex upon Delayed Development of Motor Behavior in Early Ontogenesis of Rats Exposed to Prenatal Hypoxia

Age-Dependent Electrocorticogram Dynamics and Epileptogenic Responsiveness in Rats Subjected to Prenatal Hypoxia

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