Formation of Stable Vascular Networks in Engineered Tissues

Jiang, Bin; Brey, Eric M.

doi:10.5772/23223

Cited by 8 publications

(10 citation statements)

References 116 publications

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“…The ECs of immature cells secrete signals required for migration and proliferation of MCs. They also secrete a thin layer of matrix known as the basement membrane (BM), leading to the formation of stable blood vessels (Brey, 2011).…”

Section: Vasoregressionmentioning

confidence: 99%

“…Disruption of pericyte-endothelial interaction and perivascular extracellular matrix (ECM) components such as neural cell adhesion molecule may lead to destabilization or regression of mature blood vessels (Benjamin et al, 1998;Brey, 2011;Gerhardt and Semb, 2008;Hammes et al, 2002). Regression of blood vessels may also occur once the initial network of vessels has been formed, and needs to be remodeled into its final differentiated form.…”

Section: Vasoregressionmentioning

confidence: 99%

“…Therefore, vessel regression may be caused by: a) insufficient stimulus during vessel formation leading to failure of stabilization of the vascular structure; b) EC apoptosis or loss of essential growth factors during the process of remodeling of vessels leading to their tissue-specific maturation (Brey, 2011); c) factors such as inflammation leading to pericyte loss either by apoptosis or migration (Armulik et al, 2011); and d) pathological disruption of junctional structures in the endothelium.…”

Section: Vasoregressionmentioning

confidence: 99%

See 2 more Smart Citations

Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Gupta

Bhatnagar

2015

OMICS: A Journal of Integrative Biology

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Vasoregression is a common phenomenon underlying physiological vessel development as well as pathological microvascular diseases leading to peripheral neuropathy, nephropathy, and vascular oculopathies. In this review, we describe the hallmarks and pathways of vasoregression. We argue here that there is a parallel between characteristic features of vasoregression in the ocular microvessels and atherosclerosis in the larger vessels. Shared molecular pathways and molecular effectors in the two conditions are outlined, thus highlighting the possible systemic causes of local vascular diseases. Our review gives us a system-wide insight into factors leading to multiple synchronous vascular diseases. Because shared molecular pathways might usefully address the diagnostic and therapeutic needs of multiple common complex diseases, the literature analysis presented here is of broad interest to readership in integrative biology, rational drug development and systems medicine.

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Section: Vasoregressionmentioning

confidence: 99%

Section: Vasoregressionmentioning

confidence: 99%

Section: Vasoregressionmentioning

confidence: 99%

See 1 more Smart Citation

Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Gupta

Bhatnagar

2015

OMICS: A Journal of Integrative Biology

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“…Thus, this study reveals that PPS microspheres are a generalizable transport for ROS-mediated drug release, for preventing the progression of, and possibly treating, chronic wounds that occur commonly in PAD. 171 An example of a therapeutic biomaterial used for treatment of existing chronic wounds is the application of siRNA delivered from ROS-degradable tissue engineering scaffolds, an approach shown to promote diabetic wound healing 272 COLAZO ET AL.…”

Section: Novel Biomaterialsmentioning

confidence: 99%

“…The alternative to creating cellularized vascular network preimplantation is in situ recruitment of endogenous vasculature and/or progenitor cells into a wound site or onto acellular tissue-engineered scaffolds. These approaches include micropatterning substrates to guide the formation of capillary networks integrated with the host tissue, 269 incorporating and/or delivering growth factors (such as IGF-1, substance P, plateletderived growth factor [PDGF], VEGF, angiopoietins, and ephrins [270][271][272] to modulate endogenous cell recruitment and responses, and tethering of angiogenic ECM molecules such as fibronectin, collagen I and IV, elastin, and fibrin, to promote and guide neovascularization and angiogenesis. 272,273 The ''vascularization problem'' is a commonly known problem in the field of tissue engineering.…”

Section: Engineering Vascular Graftsmentioning

confidence: 99%

Applied Bioengineering in Tissue Reconstruction, Replacement, and Regeneration

Colazo

Evans

Farinas

et al. 2019

Tissue Engineering Part B: Reviews

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To this day, tissue reconstruction and replacement to address extensive tissue defects due to trauma, tumor resection, genetic and/or chronic diseases, or excessive debridement present a major clinical challenge. Traditional reconstructive techniques most commonly utilize autologous tissue. Undoubtedly, autologous composite tissue transfers or ''flaps,'' skin grafts, as well as the harvesting of bone and/or cartilage have substantially improved the health, functional, and aesthetic outcomes of millions of patients. Unfortunately, these procedures are not without their drawbacks. These include increased operative time, complexity, cost, limited availability of qualitative autologous tissue, wound healing complications, tissue flap failure, and substantial donor-site morbidity. Recently, collaborative research teams-consisting of surgeons, scientists, and engineers-have made substantial progress in their attempts to solve these problems. This article provides historical perspective, covers the major limitations of current standards of care, and reviews recent advances and future prospects in applied bioengineering in the context of tissue reconstruction, replacement, and regeneration.

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Macro, Micro, and Everything in Between. Bridging the Gap: A Vision Toward the Creation of Multiscale Vascular Networks

Pirraco

2023

Advanced Biology

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Vascularization is a key issue for the clinical translation of tissue engineering strategies. This has been recognized in the field for almost two decades. Several strategies to solve this issue are proposed but none has decisively tackled the problem. This is in part due to an excessive focus on microvascularization that ignores the need of having macrovessels capable of being surgically connected to the patient's circulation upon implantation. Indeed, a strategy for macrovessel engineering must co‐exist with a strategy for microvessels. And if this is true, all the intermediate scales have to be addressed as well. Therefore, multiscale vascular networks must be the focus of tissue engineering vascularization efforts. In this work, a reflection is made on a possible path forward for researchers and engineers in the field to achieve the ultimate goal of efficient vascularization of engineered tissues and organs.

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Formation of Stable Vascular Networks in Engineered Tissues

Cited by 8 publications

References 116 publications

Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Vasoregression: A Shared Vascular Pathology Underlying Macrovascular And Microvascular Pathologies?

Applied Bioengineering in Tissue Reconstruction, Replacement, and Regeneration

Macro, Micro, and Everything in Between. Bridging the Gap: A Vision Toward the Creation of Multiscale Vascular Networks

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