Formation of Spherical Micelles by the Novel Platelet Activating Factor Receptor Antagonist, E5880.

Nomura, Teruko; Asai, Yasuyuki; Murahashi, Naokazu; Iwamoto, Kiyoshi

doi:10.1248/cpb.48.947

Cited by 4 publications

(2 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The scalability of this method has been largely facilitated by the synthesis of colloidal nanoparticles in various shapes, with high monodispersity, − along with simple and inexpensive production of microstructured stamps by soft lithography. ,, However, the quality of the nanomaterial is often compromised because of the well-known coffee ring effect: inhomogeneous material distribution (in the worst case, accumulation outside of the structured area) is observed when the dispersed nanoparticles are driven toward the rim of the confined droplet during drying due to convective forces (Figure a) . We recently reported that template-assisted assembly of sterically stabilized (i.e., poly(ethylene glycol)-capped) gold nanospheres (PEG–AuNSs) improved when the amount of residual surfactant cetyltrimethylammonium chloride (CTAC) in the dispersion was kept far below its critical micellar concentration (cmc of CTAC: 1.6 mM at 25 °C) . The most homogeneous structures were achieved with a surfactant concentration of around 50 μM, at which the nanospheres would slowly agglomerate in the dispersion, forming extended golden films on the hydrophobic walls of plastic storage vessels .…”

Section: Resultsmentioning

confidence: 99%

“…38 We recently reported that template-assisted assembly of sterically stabilized (i.e., poly(ethylene glycol)-capped) gold nanospheres (PEG− AuNSs) improved when the amount of residual surfactant cetyltrimethylammonium chloride (CTAC) in the dispersion was kept far below its critical micellar concentration (cmc of CTAC: 1.6 mM at 25 °C). 39 The most homogeneous structures were achieved with a surfactant concentration of around 50 μM, at which the nanospheres would slowly agglomerate in the dispersion, forming extended golden films on the hydrophobic walls of plastic storage vessels. 22 For the MUHEG-coated rods used in this study, we could neither replicate the described effects nor sufficiently suppress the dominant coffee ring effect by simply decreasing the concentration of free surfactant, which was tested down to 30 μM residual surfactant (see Figures 1b and S2).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Solvent-Assisted Self-Assembly of Gold Nanorods into Hierarchically Organized Plasmonic Mesostructures

Hanske

Hill

Vila‐Liarte

et al. 2019

ACS Appl. Mater. Interfaces

100

105

View full text Add to dashboard Cite

Plasmonic supercrystals and periodically structured arrays comprise a class of materials with unique optical properties that result from the interplay of plasmon resonances, as well as near- and far-field coupling. Controlled synthesis of such hierarchical structures remains a fundamental challenge, as it demands strict control over the assembly morphology, array size, lateral spacing, and macroscale homogeneity. Current fabrication approaches involve complicated multistep procedures lacking scalability and reproducibility, which has hindered the practical application of plasmonic supercrystal arrays. Herein, these challenges are addressed by adding an organic solvent to achieve kinetic control over the template-assisted colloidal assembly of nanoparticles from aqueous dispersion. This method yields highly regular periodic arrays, with feature sizes ranging from less than 200 nm up to tens of microns. A combined experimental/computational approach reveals that the underlying mechanism is a combination of the removal of interfacial surfactant micelles from the particle interface and altered capillary flows. Assessing the efficacy of such square arrays for surface-enhanced Raman scattering spectroscopy, we find that a decrease of the lattice periodicity from 750 nm down to 400 nm boosts the signal by more than an order of magnitude, thereby enabling sensitive detection of analytes, such as the bacterial quorum sensing molecule pyocyanin, even in complex biological media.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: ■ Results and Discussionmentioning

confidence: 99%

Solvent-Assisted Self-Assembly of Gold Nanorods into Hierarchically Organized Plasmonic Mesostructures

Hanske

Hill

Vila‐Liarte

et al. 2019

ACS Appl. Mater. Interfaces

100

105

View full text Add to dashboard Cite

show abstract

Oxidatively modified fatty acyl chain determines physicochemical properties of aggregates of oxidized phospholipids

Pande

Kar

Tripathy

2010

Biochimica et Biophysica Acta (BBA) - Biomembranes

View full text Add to dashboard Cite

In vivo oxidation of glycerophospholipid generates a variety of products including truncated oxidized phospholipids (tOx-PLs). The fatty acyl chains at the sn-2 position of tOx-PLs are shorter in length than the parent non-oxidized phospholipids and contain a polar functional group(s) at the end. The effect of oxidatively modified sn-2 fatty acyl chain on the physicochemical properties of tOx-PLs aggregates has not been addressed in detail, although there are few reports that modified fatty acyl chain primarily determines the biological activities of tOx-PLs. In this study we have compared the properties of four closely related tOx-PLs which differ only in the type of modified fatty acyl chain present at the sn-2 position: 1-palmitoyl-2-azelaoyl-sn-glycero-3-phosphocholine (PazePC), 1-palmitoyl-2-(9'-oxo-nonanoyl)-sn-glycero-3-phosphocholine (PoxnoPC), 1-palmitoyl-2-glutaroyl-sn-glycero-3-phosphocholine (PGPC), and 1-palmitoyl-2-(5'-oxo-valeroyl)-sn-glycero-3-phosphocholine (POVPC). Aggregates of individual tOx-PL in aqueous solution were characterized by fluorescence spectroscopy, size exclusion chromatography, native polyacrylamide and agarose gel electrophoresis. The data suggest that aggregates of four closely related tOx-PLs form micelle-like particles of considerably different properties. Our result provides first direct evidence that because of the specific chemical composition of the sn-2 fatty acyl chain aggregates of particular tOx-PL possess a distinctive set of physicochemical properties.

show abstract

Fabrication of metalosomes (metal containing cationic liposomes) using single chain surfactants as a precursor via formation of inorganic organic hybrids

Garg

Kaur

Chaudhary

et al. 2017

Phys. Chem. Chem. Phys.

View full text Add to dashboard Cite

Among the self-assembled forms of surfactants, vesicles/liposomes are a highly promising and interesting feature of surfactants, which are usually formed from water insoluble surfactants. Herein, we demonstrate the formation of liposomes from single-chain cationic surfactants with the help of metals as a part of the counter ion, and these metal embedded liposomes are termed as metalosomes. It is a noteworthy advancement in the area of self-assembled molecular structures since we report the preparation of metal embedded liposomes (metalosomes) from a water soluble single chain cationic surfactant, which is otherwise a property or an arrangement made by double tailed surfactants, or more precisely lipids that are poorly water soluble. We can use this method for various cationic surfactants and metal combinations and the studies are still in process. However, this preliminary report on manganese-based surfactants depicts the successful formation of cationic metalosomes (with/without cholesterol), and the formation, structure and size has been verified using TEM, FE-SEM, DLS XRD and SAXS. The comparison of metalosomes with reverse vesicles in different solvents further gave an insight of microstructure and solvent environment effects on the self-assembly of metallosurfactants. In addition, we have also evaluated the encapsulation ability of metalosomes for fluorescein dye. High encapsulation efficiency of Mn-somes makes them promising candidates for several applications, particularly because of its water solubility.

show abstract

Formation of Spherical Micelles by the Novel Platelet Activating Factor Receptor Antagonist, E5880.

Cited by 4 publications

References 1 publication

Solvent-Assisted Self-Assembly of Gold Nanorods into Hierarchically Organized Plasmonic Mesostructures

Solvent-Assisted Self-Assembly of Gold Nanorods into Hierarchically Organized Plasmonic Mesostructures

Oxidatively modified fatty acyl chain determines physicochemical properties of aggregates of oxidized phospholipids

Fabrication of metalosomes (metal containing cationic liposomes) using single chain surfactants as a precursor via formation of inorganic organic hybrids

Contact Info

Product

Resources

About