Formation of solid lipid nanoparticles in a microchannel system with a cross-shaped junction

Zhang, Songhong; Yun, Junxian; Shen, Shihua; Chen, Zhuo; Yao, Kangde; Chen, Jizhong; Chen, Bingbing

doi:10.1016/j.ces.2008.08.005

Cited by 47 publications

(48 citation statements)

References 21 publications

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“…It was also shown that the size distribution of liposomes can be relatively easily controlled by changing the flow rates of the lipid solution in organic solvent and the aqueous phase [25,26], thus making it a relatively simple and straightforward method for production of unilamellar liposomes of controllable size distribution. Several studies have also used the MHF approach to encapsulate different molecules in the aqueous interior of liposomes [25][26][27][28][29], demonstrating its applicability in drug delivery and similar pharmaceutical and medical applications.…”

Section: Introductionmentioning

confidence: 99%

“…More recently, a new approach based on hydrodynamic focusing in micro-channels [24] has been developed and successfully applied in synthesis of vesicles of various lipids, as well as other types on nanoparticles [25][26][27][28][29][30]. Microfluidic hydrodynamic focusing (MHF) is conducted by introducing the lipid solution through a central inlet channel of a microfluidic device, and focusing this central stream by the flow of an aqueous solution through two or more side channels [24].…”

Section: Introductionmentioning

confidence: 99%

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Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems

Mijajlovic

Wright

Živković

et al. 2013

Colloids and Surfaces B: Biointerfaces

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Elsevier's AAM Policy: Authors retain the right to use the accepted author manuscript for personal use, internal institutional use and for permitted scholarly posting provided that these are not for purposes of commercial use or systematic distribution.Elsevier believes that individual authors should be able to distribute their AAMs for their personal voluntary needs and interests, e.g. posting to their websites or their institution's repository, e-mailing to colleagues. However, our policies differ regarding the systematic aggregation or distribution of AAMs to ensure the sustainability of the journals to which AAMs are submitted. Therefore, deposit in, or posting to, subjectoriented or centralized repositories (such as PubMed Central), or institutional repositories with systematic posting mandates is permitted only under specific agreements between Elsevier and the repository, agency or institution, and only consistent with the publisher's policies concerning such repositories. AbstractLipid vesicles have received significant attention in areas ranging from pharmaceutical and biomedical engineering to novel materials and nanotechnology. Microfluidic-based synthesis of liposomes offers a number of advantages over the more traditional synthesis methods such as extrusion and sonication. One such microfluidic approach is microfluidic hydrodynamic focusing (MHF), which has been used to synthesize nanoparticles and vesicles of various lipids. We show here that this method can be utilized in synthesis of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) vesicles with controllable size. Since POPC is among the primary constituents of cellular membranes, this work is of direct applicability to modelling of biological systems and development of nanocontainers with higher biologic compatibility for pharmaceutical and medical applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems

Mijajlovic

Wright

Živković

et al. 2013

Colloids and Surfaces B: Biointerfaces

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“…Génot et al (2010) positioned a glass capillary at the intersection of the two branches of a Y junction to construct a 3D microfluidic mixer that was used to prepare rubrene nanocrystals. Zhang et al (2008) and Yun et al (2009) produced solid lipid nanoparticles using flow focusing devices with cross junction geometry. The particle size was controlled by varying the flow rate ratio of the two phases and introducing gas bubbles downstream of the cross junction.…”

Section: Introductionmentioning

confidence: 99%

Preparation of biodegradable polymeric nanoparticles for pharmaceutical applications using glass capillary microfluidics

Othman

Vladisavljević

Nagy

2015

Chemical Engineering Science

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The aim of this study was to develop a new microfluidic approach for the preparation of nanoparticles with tuneable sizes based on micromixing / direct nanoprecipitation in a coaxial assembly of tapered-end glass capillaries. The organic phase was 1 wt% poly(-caprolactone) (PCL) or poly(dl-lactic acid) (PLA) in tetrahydrofuran and the antisolvent was Milli-Q water.The size of nanoparticles was precisely controlled over a range of 190-650 nm by controlling phase flow rates, orifice size and flow configuration (two-phase co-flow or countercurrent flow focusing). Smaller particles were produced in a flow focusing device, because the organic phase stream was significantly narrower than the orifice and remained narrow for a longer distance downstream of the orifice. The mean size of PCL particles produced in a flow focusing device with an orifice size of 200 m, an organic phase flow rate of 1.7 mL h -1 and an aqueous-toorganic flow rate ratio of 10 was below 200 nm. The size of nanoparticles decreased with decreasing the orifice size and increasing the aqueous-to-organic phase flow rate ratio. Due to *Revised Manuscript Click here to view linked References 2 higher affinity for water and amorphous structure, PLA nanoparticles were smaller and exhibited a smoother surface and more rounded shape than PCL particles.

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“…[20][21][22] Stearic acid 50 mg and injectable soya lecithin 30 mg were accurately weighed and dissolved in 10 mL of acetone. The organic phase was added dropwise into the 0.2% dimethyldioctadecylammonium bromide solution, under stirring at 600 rpm and at room temperature.…”

Section: Preparation Of Cationic Slnmentioning

confidence: 99%

Comparison of two kinds of nanomedicine for targeted gene therapy: premodified or postmodified gene delivery systems

Jiang¹,

Sun²,

Yin³

et al. 2012

IJN

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Background:The applications of ligand-polyethylene glycol (PEG)-modified nanocarriers have now emerged, as well as recognized strategies to provide the vectors with active targeting properties. In this research, premodification and postmodification were compared using the same ligand, ie, a novel conjugated mannan-containing PEG and L-α-phosphatidylethanolamine (PE). Methods: Premodified and postmodified solid lipid nanoparticles were prepared and the characteristics of the two kinds of vehicles were evaluated. The modified vectors were then administered intravenously to rats and the in vivo targeting behavior of the complexes was investigated in liver macrophages. Results: By carefully formulating the carriers with an optimal ratio of mannan-containing PEG-PE, postmodified vehicles displayed more efficient gene expression in rat Kupffer cells both in vitro and in vivo. Conclusion: Postmodified gene carriers are superior to premodified gene vectors, although the latter is also promising for targeted gene delivery. This discovery could guide our future research.

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Formation of solid lipid nanoparticles in a microchannel system with a cross-shaped junction

Cited by 47 publications

References 21 publications

Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems

Microfluidic hydrodynamic focusing based synthesis of POPC liposomes for model biological systems

Preparation of biodegradable polymeric nanoparticles for pharmaceutical applications using glass capillary microfluidics

Comparison of two kinds of nanomedicine for targeted gene therapy: premodified or postmodified gene delivery systems

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