Formation of ROS and RNS in Water Electro-Sprayed through Transient Spark Discharge in Air and their Bactericidal Effects

Machala, Zdenko; Tarabová, Barbora; Hensel, Karol; Spetlikova, E.; Šikurová, L; Lukeš, Petr

doi:10.1002/ppap.201200113

Cited by 299 publications

(278 citation statements)

References 41 publications

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“…Several fluorescence and chemiluminescence methods were proposed for peroxynitrite analysis [16,[81][82][83][84][85][86]. All of them require incorporating a specific organic reagent, such as 2.7-dichlorodihydrofluorescein diacetate [83].…”

Section: Analysis Of Peroxynitritementioning

confidence: 99%

Chemical Effects of Air Plasma Species on Aqueous Solutes in Direct and Delayed Exposure Modes: Discharge, Post-discharge and Plasma Activated Water

Brisset

Pawłat

2015

Plasma Chem Plasma Process

150

121

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The chemical interaction between non-thermal plasma species and aqueous solutions is considered in the case of discharges in humid air burning over aqueous solutions with emphasis on the oxidizing and acidic effects resulting from formed peroxynitrite ONOO -and derived species, such as transient nitrite and stable HNO 3 . The oxidizing properties are mainly attributed to the systems ONOOONOOH tentatively splits into reactive species, e.g., nitronium NO ? and nitrosonium NO 2 ? cations. NO ? which also results from both ionization of Á NO and the presence of HNO 2 in acidic medium, is involved in the amine diazotation/nitrosation degradation processes. NO 2 ? requires a sensibly higher energy than NO ? to form and is considered with the nitration and the degradation of aromatic molecules. Such chemical properties are especially important for organic waste degradation and bacterial inactivation. The kinetic aspect is also considered as an immediate consequence of exposing an aqueous container to the discharge. The relevant chemical effects in the liquid result from direct and delayed exposure conditions. The so called delayed conditions involve both post-discharge (after switching off the discharge) and plasma activated water. An electrochemical model is proposed with special interest devoted to the chemical mechanism of bacterial inactivation under direct or delayed plasma conditions.

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Section: Analysis Of Peroxynitritementioning

confidence: 99%

Chemical Effects of Air Plasma Species on Aqueous Solutes in Direct and Delayed Exposure Modes: Discharge, Post-discharge and Plasma Activated Water

Brisset

Pawłat

2015

Plasma Chem Plasma Process

150

121

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“…One mechanism of production of these ions is dissociation of water molecules, (Eq. (1) In [31], it is shown that low-acidity liquids (buffer solution) treated with plasma discharges demonstrated higher concentration of nitrites, lower concentration of hydrogen peroxide and significantly lower decrease in pH, as compared with water. This result is correlated with the relatively small reduction in the pH value of plasma-treated TA solutions obtained in the present paper.…”

Section: Ta Solution Treated In Non-conductive Dishesmentioning

confidence: 99%

“…The hydroxyl radical can be formed through different mechanisms, including direct electronic excitation of water molecules and dissociative recombination of exited water molecules, [13][14][15] Other mechanisms of formation of the hydroxyl radical in plasma-treated water solutions can involve formation and subsequent dissociation of peroxynitrous acid and/or peroxynitrite, as discussed in [31]. Peroxynitrous acid and peroxynitrite can be formed in an acidic environment through reaction between nitrite, hydrogen peroxide and H + ions; decomposition of this acid and its conjugate (peroxynitrite) base then results in formation of OH and NO2 radicals [31].…”

Section: Introductionmentioning

confidence: 99%

“…Peroxynitrous acid and peroxynitrite can be formed in an acidic environment through reaction between nitrite, hydrogen peroxide and H + ions; decomposition of this acid and its conjugate (peroxynitrite) base then results in formation of OH and NO2 radicals [31]. As indicated in [2] and [31], these complex processes of formation of OH radicals through chemical reactions involving nitrites, nitrates, hydrogen peroxide and ozone are not fully understood and further investigations are needed: for example, direct measurements of the main chemical species generated by plasma discharges (hydrogen peroxide and others) could be importart for further understanding of these plasma-induced chemical processes in water-based solutions.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescence detection of hydroxyl radicals in water produced by atmospheric pulsed discharges

Timoshkin

Maclean

et al. 2015

IEEE Trans. Dielect. Electr. Insul.

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It has been proven that hydroxyl (OH) radicals can be generated by streamer discharges across water surfaces under ambient atmospheric conditions. Hydroxyl radicals have the highest oxidation capability amongst all oxygen-based reactive species, thus OH play an important role in oxidation of organic molecules and the bactericidal effects of plasma discharges. In this study, generation of hydroxyl radicals in water by pulsed streamer discharges was investigated. Terephthalic acid was used as a chemical probe as this acid is converted into 2-hydroxyterephthalic acid (HTA) by chemical reaction with OH radicals. The concentration of OH radicals was quantified by measuring the fluorescence light intensity generated by HTA molecules in water solutions. Both positive and negative pulsed discharges with different voltage levels were tested. Two different types of sample holder -non-conductive plastic dishes, and dishes lined with conductive aluminum foilwere used in order to investigate the effect of the discharge propagation path on the efficiency of OH production. The efficiency of OH production was measured as a function of: the distance between the needle electrode and the water surface; the magnitude and polarity of HV energization; and the total delivered charge. The obtained results will help in optimization of non-thermal plasma systems for chemical and biological decontamination.

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“…Upon contact with ambient atmosphere, LTP reacts with molecular content of air (N 2 , O 2 , H 2 O vapor), generating a variety of reactive oxygen and nitrogen species (RONS) 2,4 . Among these are relatively stable species (such as hydrogen peroxide, ozone, nitrite and nitrate anions) and highly reactive radicals (•OH, •OOH/O 2 • -, •H, •NO, etc.).…”

Section: Introductionmentioning

confidence: 99%

An Atmospheric Pressure Plasma Setup to Investigate the Reactive Species Formation

Gorbanev

Soriano

O’Connell

et al. 2016

JoVE

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Non-thermal atmospheric pressure ('cold') plasmas have received increased attention in recent years due to their significant biomedical potential. The reactions of cold plasma with the surrounding atmosphere yield a variety of reactive species, which can define its effectiveness. While efficient development of cold plasma therapy requires kinetic models, model benchmarking needs empirical data. Experimental studies of the source of reactive species detected in aqueous solutions exposed to plasma are still scarce. Biomedical plasma is often operated with He or Ar feed gas, and a specific interest lies in investigation of the reactive species generated by plasma with various gas admixtures (O 2 , N 2 , air, H 2 O vapor, etc.) Such investigations are very complex due to difficulties in controlling the ambient atmosphere in contact with the plasma effluent. In this work, we addressed common issues of 'high' voltage kHz frequency driven plasma jet experimental studies. A reactor was developed allowing the exclusion of ambient atmosphere from the plasma-liquid system. The system thus comprised the feed gas with admixtures and the components of the liquid sample. This controlled atmosphere allowed the investigation of the source of the reactive oxygen species induced in aqueous solutions by He-water vapor plasma. The use of isotopically labelled water allowed distinguishing between the species originating in the gas phase and those formed in the liquid. The plasma equipment was contained inside a Faraday cage to eliminate possible influence of any external field. The setup is versatile and can aid in further understanding the cold plasma-liquid interactions chemistry.

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Formation of ROS and RNS in Water Electro-Sprayed through Transient Spark Discharge in Air and their Bactericidal Effects

Cited by 299 publications

References 41 publications

Chemical Effects of Air Plasma Species on Aqueous Solutes in Direct and Delayed Exposure Modes: Discharge, Post-discharge and Plasma Activated Water

Chemical Effects of Air Plasma Species on Aqueous Solutes in Direct and Delayed Exposure Modes: Discharge, Post-discharge and Plasma Activated Water

Fluorescence detection of hydroxyl radicals in water produced by atmospheric pulsed discharges

An Atmospheric Pressure Plasma Setup to Investigate the Reactive Species Formation

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