Formation of progesterone receptor-NF-[kappa]B complex is required for progesterone-induced NF-[kappa]B nuclear translocation and binding onto the p53 promoter

Delineation of critical amino acids in activation function 1 of progesterone receptor for recruitment of transcription coregulators

“…In addition to regulating gene expression through its interaction with cognate gene enhancer sequences known as the progesterone response element (PRE), PR also regulates gene transcription through an indirect effect by tethering to other transcriptional factors such as activating protein 1 (AP1), nuclear factor kappa-B (NFB) and specificity protein 1 (SP1) [63][64][65][66][67][68][69]. The outcome is usually the repression of gene activation by these transcription factors and this mode of action has been implicated in the anti-inflammatory function of progesterone [64,65].…”