Formation of poly(l,d-lactide) spheres with controlled size by direct dialysis

Zhou, Zhimin; Xu, Jun; Yang, Kun; Cui, Qiang; Chen, Xin; Cao, Minyuan; Weng, Jian; Zhang, Qiqing

doi:10.1016/j.polymer.2007.07.053

Cited by 33 publications

(18 citation statements)

References 33 publications

(17 reference statements)

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“…This may be due to the shrinkage of the micelles during the drying process when TEM samples were made. 45,46 ph sensitivity of the mixed micelles…”

mentioning

confidence: 99%

pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity

Yan¹,

Li²,

Zhu³

et al. 2017

IJN

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The aim of this study was to simultaneously introduce pH sensitivity and folic acid (FA) targeting into a micelle system to achieve quick drug release and to enhance its accumulation in tumor cells. Paclitaxel-(+)-α-tocopherol (PTX-VE)-loaded mixed micelles (PHIS/FA/PM) fabricated by poly(ethylene glycol) methyl ether-poly(histidine) (MPEG-PHIS) and folic acid-poly(ethylene glycol)-(+)-α-tocopherol (FA-PEG-VE) were characterized by dynamic light scattering and transmission electron microscopy (TEM). The mixed micelles had a spherical morphology with an average diameter of 137.0±6.70 nm and a zeta potential of −48.7±4.25 mV. The drug encapsulation and loading efficiencies were 91.06%±2.45% and 5.28%±0.30%, respectively. The pH sensitivity was confirmed by changes in particle size, critical micelle concentration, and transmittance as a function of pH. MTT assay showed that PHIS/FA/PM had higher cytotoxicity at pH 6.0 than at pH 7.4, and lower cytotoxicity in the presence of free FA. Confocal laser scanning microscope images demonstrated a time-dependent and FA-inhibited cellular uptake. In vivo imaging confirmed that the mixed micelles targeted accumulation at tumor sites and the tumor inhibition rate was 85.97%. The results proved that the mixed micelle system fabricated by MPEG-PHIS and FA-PEG-VE is a promising approach to improve antitumor efficacy.

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“…This may be due to the shrinkage of the micelles during the drying process when TEM samples were made. 45,46 ph sensitivity of the mixed micelles…”

mentioning

confidence: 99%

pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity

Yan¹,

Li²,

Zhu³

et al. 2017

IJN

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“…Therefore, the model drug and small molecules affected certain parameters (such as size, shape, charge) of particles, which was in agreement with previous reports. 8,[23][24][25] Then, we used FITC-BSA to prepare FITC-FBSA particles according to the aforementioned method. The shape of the FITC-FBSA particles ( Figure 2C) was almost the same as those of FBSA.…”

Section: Morphology Of Fbsa Particlesmentioning

confidence: 99%

“…As for the good cytocompatibility and the higher activity of amino residue, 24 FBSA-H particle-loaded RhB was chosen to investigate the penetration of RhB through the RWM. The soft surface made of natural protein had the advantage of constructing the carriers, because cells had the ability to sense the hardness of the culture surface.…”

Section: In Vivo Distribution Of Fbsa-rhbmentioning

confidence: 99%

Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane

Yu¹,

Yu²,

Zhou

et al. 2014

IJN

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Controlled-release carriers for local drug delivery have attracted increasing attention for inner-ear treatment recently. In this paper, flower-shaped bovine serum albumin (FBSA) particles were prepared by a modified desolvation method followed by glutaraldehyde or heat denaturation. The size of the FBSA particles varied from 10 μm to 100 μm, and most were 50–80 μm. Heat-denatured FBSA particles have good cytocompatibility with a prolonged survival time for L929 cells. The FBSA particles were utilized as carriers to investigate the release behaviors of the model drug – rhodamine B. Rhodamine B showed a sustained-release effect and penetrated the round-window membrane of guinea pigs. We also confirmed the attachment of FBSA particles onto the round-window membrane by microscopy. The FBSA particles, with good biocompatibility, drug-loading capacity, adhesive capability, and biodegradability, may have potential applications in the field of local drug delivery for inner-ear disease treatment.

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“…Hence, we intend to overcome this limitation by fabricating polymeric nanoparticulate drug delivery system. However, polymeric nanoparticles can be prepared by various techniques including solvent evaporation (Hoa et al, 2012), salting-out (Rao et al, 2011), nanoprecipitation (Yordanov et al, 2010), polymerization, dialysis (Liu et al, 2007), nano spray drying (Elzoghby et al, 2012), polycondensation, desolvation (Gülseren et al, 2012), ionic gelation (Fan et al, 2012) and supercritical fluid technology (Sekhon, 2010), but the selection of an optimal method was a real concern, as the selection of an unsuitable method may result in loss of time, material and financial resources (Moorthi et al, 2013). Hence, we intended to apply Analytical Hierarchy Process (AHP) decision-making tool in the selection of an optimal method for the preparation of dual loaded flavono polymeric nanoparticles.…”

Section: Introductionmentioning

confidence: 99%

Selection of an optimal method for the preparation of dual loaded flavono polymeric nanoparticle using analytical hierarchy process

Chinnamaruthu

Sellappan

2014

Int Curr Pharm J

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In this study, analytical hierarchy process was used to select an optimal method for the preparation of dual loaded flavono polymeric nanoparticles. Analytical hierarchy process involves structuring multiple choice criteria into a hierarchy, assessing the relative importance of criteria, comparing alternatives for each criterion and determining an overall ranking of the alternatives. Hierarchy model was developed with the goal in the first level, 10 criteria in the second level and methods for the preparation of polymeric nanoparticles in the third level. To assess the relative importance of criteria, all criteria were compared with each other using Saatys scale. To compare the methods, all the methods for the preparation of polymeric nanoparticles were compared with each other for each criterion using Saatys scale, which leads to the formation of pair-wise comparison matrixes and consistency ratio was calculated for the each pair-wise comparison matrix. The study result showed that the consistency ratio of each pair-wise comparison matrix were well within acceptable limits. Of 10 criteria, reproducible results received the maximum overall priority weight followed by desirable size. Of 10 methods, nanoprecipitation method received the maximum overall priority weight followed by supercritical fluid technology. Analytical hierarchy process has identified reproducible results as criteria preference and nanoprecipitation as an optimal method for the preparation of dual loaded flavono polymeric nanoparticles. The study concludes that the analytical hierarchy process has played a vital role in selecting an optimal method for the preparation of dual loaded flavono polymeric nanoparticles.DOI: http://dx.doi.org/10.3329/icpj.v3i4.18264 International Current Pharmaceutical Journal, March 2014, 3(4): 247-253

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Formation of poly(l,d-lactide) spheres with controlled size by direct dialysis

Cited by 33 publications

References 33 publications

pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity

pH-sensitive and folic acid-targeted MPEG-PHIS/FA-PEG-VE mixed micelles for the delivery of PTX-VE and their antitumor activity

Novel flower-shaped albumin particles as controlled-release carriers for drugs to penetrate the round-window membrane

Selection of an optimal method for the preparation of dual loaded flavono polymeric nanoparticle using analytical hierarchy process

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