Formation of pH-Responsive Supramolecular Hydrogels in Basic Buffers: Self-assembly of Amphiphilic Tris-Urea

Kimura, Shinya; Haraya, Nana; Komiyama, Tomoki; Yokoya, Masashi; Yamanaka, Masamichi

doi:10.1248/cpb.c21-00539

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…In addition, hydrogen bonding-based amphiphilic supramolecular gels are greatly impacted by pH, resulting in the collapse of supramolecular aggregates when an acid or basic is introduced. Kimura with co-workers designed a C3-symmetric amphiphilic tris-urea compound that is capable of forming supramolecular hydrogels in basic borate-NaOH buffers (S. Kimura et al, 2021). The gel-sol phase, on the other hand, can be transformed by adding the appropriate amount of NaOH or boric acid.…”

Section: Phmentioning

confidence: 99%

Chiral fiber supramolecular hydrogels for tissue engineering

Wang

Feng

2022

WIREs Nanomed Nanobiotechnol

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Tissue engineering (TE), as a new interdisciplinary discipline, aims to develop biological substitutes for repairing damaged tissues and organs. For the success of tissue regeneration, such biomaterials need to support the physiological activities of cells and allow the growth and maturation of tissues.Naturally, this regulation is achieved through the dynamic remodeling of the extracellular matrix (ECM) of cells. In recent years, chiral supramolecular hydrogels have shown higher application potential in the TE field than traditional polymer hydrogels due to their dynamic noncovalent interactions, adjustable self-assembly structure, and good biocompatibility. These advantages make it possible to construct hydrogels under physiological conditions with structure and function similar to those of the natural ECM.Meanwhile, the chiral characteristics of hydrogels play an important role in regulating cellular activities such as differentiation, adhesion, and proliferation, which is beneficial for tissue formation. In this review, a brief introduction is presented to highlight the importance of chiral fiber supramolecular hydrogels for TE at first. Afterward, the considerations for chiral supramolecular hydrogel design, as well as the influence of external stimuli on chiral hydrogel construction, are discussed. Finally, the potential application prospects of these materials in TE and the significant contribution made by our group in this field are summarized. This review not only helps to reveal the importance of chiral properties in TE but also provides new strategies for TE research based on chiral bionic microenvironments.

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Section: Phmentioning

confidence: 99%

Chiral fiber supramolecular hydrogels for tissue engineering

Wang

Feng

2022

WIREs Nanomed Nanobiotechnol

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“…13) Consequently, a method with good reproduc-ibility using small sample volumes (in the order of μL) was established. [14][15][16] In this study, we examined the effect of pH on hydrogel formation of BSA, and hydrogel was formed even in strongly acidic solutions. Moreover, viscoelastic properties of BSA hydrogels were measured and further reduction of sample volume was evaluated.…”

Section: Introductionmentioning

confidence: 99%

Bovine Serum Albumin Hydrogel Formation: pH Dependence and Rheological Analyses

et al. 2023

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In vitro evaluation of the physical properties of biopolymer-based hydrogels can help in understanding certain phenomena, such as liquid-liquid phase separation. The formation of bovine serum albumin (BSA) hydrogels was investigated in the pH range of 1.0 to 4.0. Hydrogels were formed in the pH range of 3.0 to 4.0, whereas viscous solutions were formed in the pH range of 1.5 to 2.5. Unexpectedly, formation of BSA hydrogel was observed in extremely acidic condition (pH 1.0). The circular dichroism spectra of BSA solutions were recorded at pH values of 1.0, 2.0, 3.0, and 7.0, and α-helix contents were determined from the ellipticity data at 222 nm. The α-helix content decreased with a decrease in pH, and this decrease was associated with the partial denaturation (F-isoform) and the denaturation (E-isoform) of BSA. However, the α-helix contents at pH 1.0 and 3.0 were similar. BSA hydrogels at pH 1.0 and 3.5 showed similar dynamic viscoelastic properties, further supporting the stereo structural change of BSA from the denatured E-isoform to the partially denatured F-isoform at pH 1.0. The study also focused on measuring viscoelasticity, a fundamental physical property of hydrogels, using traditional rheometer and with minimal sample volume. A highly reproducible procedure for measuring the viscoelastic properties of hydrogels was established using sample volumes of 200 and 350 μL.

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New Ureas and Amides - An Account of Recent Trends and Developments in Low Molecular Weight Gelators

Patel,

Bhardwaj,

Ballabh

2024

COC

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The last 20 years have witnessed major advancements in the field of supramolecular chemistry and have brought us closer to the designing of low molecular weight gelators with desired properties and applications. In that regard, amide- and urea- based gelators comprise a unique class as they are extremely versatile in terms of molecular design and offer a wide range of applications, like anion responsive materials, selective sensing of heavy metal ions, environmental remediation and many more. Both sets of compounds have similar molecular scaffolds, making them an excellent tool to determine the relative importance of the supramolecular interactions involved in the gelation process. Besides, the concept of crystal engineering can also be employed to understand the underlying mechanism of gelation by scrutinizing the interactions and supramolecular assemblies formed by these systems. In this chapter, we focus on various supramolecular assemblies formed by various amide and urea derivatives and their recently reported applications to establish structure-property correlation and their futuristic aspects.

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Formation of pH-Responsive Supramolecular Hydrogels in Basic Buffers: Self-assembly of Amphiphilic Tris-Urea

Cited by 3 publications

References 35 publications

Chiral fiber supramolecular hydrogels for tissue engineering

Chiral fiber supramolecular hydrogels for tissue engineering

Bovine Serum Albumin Hydrogel Formation: pH Dependence and Rheological Analyses

New Ureas and Amides - An Account of Recent Trends and Developments in Low Molecular Weight Gelators

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