“…62,64,82,84 As discussed previously, while photo-initiated riboflavin can react with lysine and arginine, these amino acids play a minor role in riboflavin-initiated crosslinking 83 and thus it makes sense riboflavin-465 nm would not favor the formation of pentosidine at day 0. Further, pentosidine crosslinks take longer to form than many other AGEs, 64,82,84 thus it would not be expected to form after 1 hour of treatment, as is also observed in the ribose constructs. Originally, pentosidine was hypothesized to form by reaction of pentose sugars only; 62 however later studies demonstrated glucose, fructose, ascorbate, tetrose, triose, and other glycated proteins were also possible precursors with longer incubations.…”