Formation of paratacamite nanomaterials via the conversion of aged and oxidized copper nanoparticles in hydrochloric acidic media

Elzey, Sherrie; Baltrušaitis, Jonas; Bian, Shao‐Wei; Grassian, Vicki H.

doi:10.1039/c0jm03705b

Cited by 44 publications

(28 citation statements)

References 32 publications

(52 reference statements)

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“…See Ref [27] for further details. The oxidized shell increases in thickness relative to the core upon aging of the NPs in the ambient environment, i.e.…”

Section: Methodsmentioning

confidence: 99%

Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model

et al. 2011

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BackgroundHuman exposure to nanoparticles (NPs) and environmental bacteria can occur simultaneously. NPs induce inflammatory responses and oxidative stress but may also have immune-suppressive effects, impairing macrophage function and altering epithelial barrier functions. The purpose of this study was to assess the potential pulmonary effects of inhalation and instillation exposure to copper (Cu) NPs using a model of lung inflammation and host defense.MethodsWe used Klebsiella pneumoniae (K.p.) in a murine lung infection model to determine if pulmonary bacterial clearance is enhanced or impaired by Cu NP exposure. Two different exposure modes were tested: sub-acute inhalation (4 hr/day, 5 d/week for 2 weeks, 3.5 mg/m3) and intratracheal instillation (24 hr post-exposure, 3, 35, and 100 μg/mouse). Pulmonary responses were evaluated by lung histopathology plus measurement of differential cell counts, total protein, lactate dehydrogenase (LDH) activity, and inflammatory cytokines in bronchoalveolar lavage (BAL) fluid.ResultsCu NP exposure induced inflammatory responses with increased recruitment of total cells and neutrophils to the lungs as well as increased total protein and LDH activity in BAL fluid. Both inhalation and instillation exposure to Cu NPs significantly decreased the pulmonary clearance of K.p.-exposed mice measured 24 hr after bacterial infection following Cu NP exposure versus sham-exposed mice also challenged with K.p (1.4 × 105 bacteria/mouse).ConclusionsCu NP exposure impaired host defense against bacterial lung infections and induced a dose-dependent decrease in bacterial clearance in which even our lowest dose demonstrated significantly lower clearance than observed in sham-exposed mice. Thus, exposure to Cu NPs may increase the risk of pulmonary infection.

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“…See Ref [27] for further details. The oxidized shell increases in thickness relative to the core upon aging of the NPs in the ambient environment, i.e.…”

Section: Methodsmentioning

confidence: 99%

Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model

et al. 2011

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“…Surface area of the supports along with the metals loaded on Mo2C/η-Al2O3, Mo2C/γ-Cu metal diffraction lines (JCPDS 04-0836) appeared at 2θ= 43.60 and 50.81° corresponding to (111) and (200), respectively. The 20 Cu-Mo2C catalyst showed an extra diffraction line at 2θ= 39.51° corresponding to copper oxide phase[34].Table 1shows the surface area of the Cu or Pt-modified Mo2C or Mo2C/Al2O3 supports.…”

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confidence: 99%

A highly active and synergistic Pt/Mo2C/Al2O3 catalyst for water-gas shift reaction

Osman

Abu‐Dahrieh

Cherkasov

et al. 2018

Molecular Catalysis

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Evgeny (2018) A highly active and synergistic Pt/Mo 2 C/Al 2 O 3 catalyst for water-gas shift reaction. Molecular Catalysis, AbstractCatalysts consisting of Pt and Cu supported on Mo2C/η-Al2O3, Mo2C/γ-Al2O3 or Mo2C were prepared and used for the low-temperature water gas shift reaction. The catalysts were characterized by elemental analysis, X-ray diffraction (XRD), temperature-programmed reduction (TPR), X-ray photoelectron spectroscopy (XPS) and scanning electron microscopy (SEM). The catalysts were studied in water gas shift reaction (WGSR) with a reaction mixture containing 11 % CO, 43 % H2, 6% CO2, 21 % H2O (real feed composition mixture from the reformer) andbalance He, with a reaction temperature range of 180-300 °C at a space velocity (SV) of 125,000 h -1 . Catalyst supports (η-Al2O3 and γ-Al2O3), led to different synergetic effect between the two most active phases of Pt metal and Mo2C. Pt/ Mo2C/η-Al2O3 is a promising catalyst (44% conversion at 180°C) due to the close interaction between Pt and Mo2C phases on the surface of the catalyst. The 4 Pt-Mo2C showed the highest activity where the temperature at which 50% 3 conversion observed was at only 180 ºC with SV of 125,000 h -1 and constant stability over 85 hours.

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“…XRD of the NPs showed the presence of three phases, metallic Cu core, Cu2O and CuO. The thickness of these oxidized layers depends on both the preparation of the NPs and exposure to air as NPs age under atmospheric conditions (Elzey et al 2011). The surface area of Cu NPs was 12 ± 0.2 m 2 /g by a multi-point BET analysis.…”

Section: Particle Characterizationmentioning

confidence: 98%

“…The Cu NPs were characterized using X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and BET techniques as described previously (Pettibone et al 2008a). The Cu NPs show a core/shell morphology with a metallic Cu core and an oxidized shell consisting of Cu2O (Cuprite) and CuO (tenorite), with CuO on the surface of the particles (Elzey et al 2011).…”

Section: Source and Characterization Of Npsmentioning

confidence: 99%

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Evaluating pulmonary toxicity of engineered metal-based nanoparticles using in vivo and in vitro models

Kim¹

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The overall goals of this doctoral dissertation were to 1) assess effects of nanoparticle (NP) exposure on host defense in a murine pulmonary infection model, 2) evaluate an integrated dynamic in vitro exposure system (DIVES) that overcomes limitations of submerged exposure systems for NP toxicity testing and 3) provide information on the rank of NP toxicity and assess the potential of the DIVES as a screening tool for NP toxicity.To achieve the first goal, we used Klebsiella pneumoniae (K.p.) in a murine lung infection model to determine if pulmonary bacterial clearance is enhanced or impaired by copper (Cu) NP exposure. Cu NP exposure induced strong inflammatory responses and an impairment in host defense against bacterial lung infections in both inhalation and instillation exposure studies even though there was an upregulation of pro-inflammatory cytokines and recruitment of neutrophils to the lungs. Thus, Cu NP exposure may lead to increased risk of pulmonary infection by impairing host defense against bacteria.In the second study, we integrated the DIVES capable of generating NP aerosols and depositing NPs directly onto cells grown at the air-liquid interface (ALI) to mimic a more realistic in vivo pulmonary exposure to inhaled NPs. Furthermore, we characterized the efficiency of NP delivery, the distribution of particle deposition and the effects of exposure conditions in the DIVES on the viability of A549 cells (human alveolar type-II-like cancer cells) as a precursor to studies of NP toxicity. The DIVES was shown to provide efficient, uniform and controlled dosing of particles to epithelial cells grown at the ALI. In addition, this exposure system delivered a continuous airborne-exposure of NPs to lung cells without loss of cellular viability.2 Lastly, to assess the DIVES as a means to rank NP toxicity and prioritize NPs for in vivo testing, we compared in vitro measurements obtained using the DIVES and the submerged exposure system to in vivo results obtained using a murine model of lung inflammation. Exposure to Cu NPs induced a significant increase in cytotoxicity and inflammatory responses compared to Fe NPs at the ALI in the DIVES. The results of this comparison suggest that air-delivery of NPs to lung cells using the DIVES can provide evidence of toxicity at a lower concentration of NPs compared to responses in the submerged condition. More importantly, our in vitro results presented in this dissertation are in agreement with our in vivo findings showing that Cu NPs have a higher propensity for NP dissolution and this may contribute to the greater toxicity of Cu NPs than Fe NPs.Thus, the results of these comparisons suggest that the DIVES has a significant potential for screening NP toxicity and allows for a higher throughput than in vivo studies.Overall, we found that exposure of lung cells at the ALI using the DIVES is preferable to submerged exposure for in vitro NP toxicity testing and provides useful information on the rank of NP toxicity and prioritization of NPs for in vivo testing.Abstract A...

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Formation of paratacamite nanomaterials via the conversion of aged and oxidized copper nanoparticles in hydrochloric acidic media

Cited by 44 publications

References 32 publications

Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model

Effects of copper nanoparticle exposure on host defense in a murine pulmonary infection model

A highly active and synergistic Pt/Mo2C/Al2O3 catalyst for water-gas shift reaction

Evaluating pulmonary toxicity of engineered metal-based nanoparticles using in vivo and in vitro models

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