Formation of papillary mucosa folds and enhancement of epithelial barrier in odontogenic sinusitis

Zhang, Yuan; Feng, Lan; Liu, Ying; Zhang, Luo

doi:10.1002/alr.22277

Cited by 19 publications

(16 citation statements)

References 26 publications

(27 reference statements)

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“…We assume that PM2.5 might have impact on both mRNA and protein levels. ZO-1 and claudin-7 mRNA elevation in response to PM2.5 exposure might reflect a defensive feedback mechanism of normal epithelial barrier, which has been observed in epithelium exposed to anaerobic bacteria or Staphylococcus aureus 3233. On the other hand, PM2.5 might also affect TJ molecules expression post-transcriptionally by different mechanisms, which called for further studies.…”

Section: Discussionmentioning

confidence: 95%

Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells

Xian

Wang

et al. 2020

Allergy Asthma Immunol Res

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101

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The effect of air pollution-related particulate matter (PM) on epithelial barrier function and tight junction (TJ) expression in human nasal mucosa has not been studied to date. This study therefore aimed to assess the direct impact of PM with an aerodynamic diameter less than 2.5 (PM2.5) on the barrier function and TJ molecular expression of human nasal epithelial cells. METHODS: Air-liquid interface cultures were established with epithelial cells derived from noninflammatory nasal mucosal tissue collected from patients undergoing paranasal sinus surgery. Confluent cultures were exposed to 50 or 100 g/mL PM2.5 for up to 72 hours, and assessed for 1) epithelial barrier integrity as measured by transepithelial resistance (TER) and permeability of fluorescein isothiocyanate (FITC) 4 kDa; 2) expression of TJs using real-time quantitative polymerase chain reaction and immunofluorescence staining, and 3) proinflammatory cytokines by luminometric bead array or enzyme-linked immunosorbent assay. RESULTS: Compared to control medium, 50 and/or 100 g/mL PM2.5-treatment 1) significantly decreased TER and increased FITC permeability, which could not be restored by budesonide pretreatment; 2) significantly decreased the expression of claudin-1 messenger RNA, claudin-1, occludin and ZO-1 protein; and 3) significantly increased production of the cytokines interleukin-8, TIMP metallopeptidase inhibitor 1 and thymic stromal lymphopoietin. CONCLUSIONS: Exposure to PM2.5 may lead to loss of barrier function in human nasal epithelium through decreased expression of TJ proteins and increased release of proinflammatory cytokines. These results suggest an important mechanism of susceptibility to rhinitis and rhinosinusitis in highly PM2.5-polluted areas.

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Section: Discussionmentioning

confidence: 95%

Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells

Xian

Wang

et al. 2020

Allergy Asthma Immunol Res

Self Cite

101

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“…In this study, histopathological investigation of intractable OMS revealed that the maxillary sinus mucosa appeared gyrus‐like in appearance and that the number of ciliated epithelial cells did not decrease, goblet cells were not hypertrophic and the secretions were not viscous but purulent. Zhang et al reported that small papillary protrusions could be seen in the maxillary sinus mucosa of OMS under nasal endoscopy, similar to the morphological behavior, which also presented as papillary folds in the surface of the epithelium . And papillary‐like fold mucosa of OMS was covered with intact pseudostratified columnar ciliated epithelium .…”

Section: Discussionmentioning

confidence: 84%

“…Zhang et al reported that small papillary protrusions could be seen in the maxillary sinus mucosa of OMS under nasal endoscopy, similar to the morphological behavior, which also presented as papillary folds in the surface of the epithelium . And papillary‐like fold mucosa of OMS was covered with intact pseudostratified columnar ciliated epithelium . Raman et al reported that odontogenic chronic rhinosinusitis exhibited increased moderate‐severe inflammation compared to chronic rhinosinusitis without nasal polyp, had decreased squamous metaplasia and fibrosis compared to chronic rhinosinusitis with nasal polyp, and exhibited some eosinophilia but to a lesser extent than chronic rhinosinusitis with nasal polyp .…”

Section: Discussionmentioning

confidence: 88%

Histopathology of maxillary sinus mucosa with odontogenic maxillary sinusitis

Sato

Chitose

Satô

et al. 2020

Laryngoscope Investig Oto

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Objective: Histopathology of the maxillary sinus mucosa with intractable odontogenic maxillary sinusitis (OMS) was investigated and the role endoscopic sinus surgery (ESS) plays in its pathophysiology was clarified.Study Design: Histopathological analysis of the OMS mucosa.Methods: Surgical specimens were obtained from 20 patients who underwent ESS for intractable OMS. For rigid endoscopic observation of the mucosae, a 70 rigid endoscope 4 mm in diameter with an attached high definition surgical camera was used. Histopathological analyses of the maxillary sinus mucosa were conducted by light and scanning electron microscopy.Results: All the maxillary sinuses were filled, not with viscous, but with purulent secretions. The high-definition camera showed that the maxillary sinus mucosa had gyrus-like appearance. Light microscopic histopathological studies revealed that the surface of the maxillary sinus mucosa was convoluted. Light and scanning electron microscopic histopathological studies revealed that the ciliated cells of the epithelium had not decreased and their goblet cells were not hypertrophic, indicating that the damage of the ciliated columnar epithelium was not severe and they were not injured irreversibly. Conclusion:The ciliated columnar epithelium with intractable OMS was not severely damaged and not irreversibly injured. Hence, the pathophysiology of intractable OMS is one of the reasons why ESS is highly indicated for maxillary sinusitis requiring surgery and the treatment results are exceptionally good when the ventilation and drainage of the maxillary sinus is successfully restored after surgery. Level ofEvidence: NA K E Y W O R D S endoscopic sinus surgery, histopathology, maxillary sinus mucosa, odontogenic maxillary sinusitis, pathophysiology

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“…Our previous histopathological investigation of intractable OMS revealed that the maxillary sinus mucosa appeared gyrus-like in appearance and that the number of ciliated epithelial cells did not decrease, goblet cells were not hypertrophic and the secretions were not viscous but purulent [14] . Zhang et al reported similar histopathological findings that the maxillary sinus mucosa of OMS presented as papillary folds in the surface of the epithelium and papillary-like folded mucosa was covered with intact pseudostratified columnar ciliated epithelium [15] .…”

Section: Histopathology Of the Maxillary Sinus Mucosa Of Omsmentioning

confidence: 75%

Pathophysiology of current odontogenic maxillary sinusitis and endoscopic sinus surgery preceding dental treatment

et al. 2021

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The successful management of odontogenic maxillary sinusitis (OMS) involves a combination of medical treatment with dental surgery and/or endoscopic sinus surgery (ESS). However, there is no consensus for the optimal timing of ESS. Although several studies have emphasized dental surgery as the primary treatment modality for OMS, there is recent evidence to suggest that ESS alone may be an effective treatment approach. The purpose of this study is to retrospectively investigate the pathophysiology of the current intractable OMS and the role ESS, especially ESS preceding dental treatment, plays in its pathophysiology. Methods: Ninety-seven adults (60 males and 37 females, 48 ± 12 years) who underwent ESS for intractable OMS were retrospectively examined. Results: In a great deal of the cases (85 cases, 87.6%), causative teeth of OMS were periapical lesions after root canal treatment (endodontics). The root canal procedures were not sufficient; hence, the root-canal-treated teeth had periapical lesions causing OMS. In postoperative nasal endoscopy and cone-beam CT scans for all patients, the natural ostiums and the membranous portions of the maxillary sinuses were enlarged and the ostiomeatal complexes remained widely open. The ventilation and drainage of all patients' maxillary sinuses seemed to be successfully restored. Temporary acute sinusitis recurrence after primary ESS for OMS was observed in 10 cases (11.8%) when the patients caught a cold. However, since the natural ostium and the membranous portion of the maxillary sinuses and the ostiomeatal complexes remained widely open, antibiotic administration alone without dental treatment cured the temporary acute sinusitis. Regarding the causative teeth (endodontic treated teeth), in 83 out of 85 cases (97.6%), causative teeth were able to be preserved with only antibiotic treatment and without dental retreatment. In two cases, extraction of the teeth was necessary because the teeth became mobile.

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Formation of papillary mucosa folds and enhancement of epithelial barrier in odontogenic sinusitis

Cited by 19 publications

References 26 publications

Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells

Particulate Matter 2.5 Causes Deficiency in Barrier Integrity in Human Nasal Epithelial Cells

Histopathology of maxillary sinus mucosa with odontogenic maxillary sinusitis

Pathophysiology of current odontogenic maxillary sinusitis and endoscopic sinus surgery preceding dental treatment

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