Formation of osteoclast-like cells on HA and TCP ceramics

Detsch, Rainer; Mayr, Helmar; Ziegler, Günther

doi:10.1016/j.actbio.2007.03.014

Cited by 164 publications

(124 citation statements)

References 22 publications

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“…In order to evaluate the drug-substance release as well as the biocompatibility and the osteoconductivity of such delivery systems, in vivo studies must be carried out. These tests require animals and cell cultures (39) and are consequently often long and expensive. Therefore, in vitro dissolution tests could be used in the first development stages prior to the in vivo experiments, as for drug products.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Three Dissolution Apparatuses for Testing Calcium Phosphate Pellets used as Ibuprofen Delivery Systems

Chevalier

Viana

Artaud³

et al. 2009

AAPS PharmSciTech

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Abstract. Porous calcium phosphate pellets were produced according to two granulation processes (low and high shear wet granulations) and drug loaded with five ibuprofen contents (1.75%, 7%, 12.5%, 22%, and 36%) in order to ensure both bone defect filling and local drug delivery. The drug-release kinetics from the two types of pellets was studied using three dissolution apparatuses: paddle apparatus, reciprocating cylinder, and flow-through cell. The paper compared the three dissolution methods and considered the effect of the granulation process on the ibuprofen-release kinetics. Dissolution data were analyzed using the Weibull function as well as the difference (f1) and similarity (f2) factors. Dissolution kinetics was not influenced by the granulation process, regardless of the dissolution apparatus and of the drug content. The comparison of the three dissolution devices indicated that ibuprofen was released faster from granules loaded with 36% of drug content with the reciprocating apparatus, due to the disintegration of the granules occurring during the dissolution test. For the other drug contents, dissolution profiles were not significantly different from one apparatus to another. However, the flowthrough cell seemed to be more suitable for the drug-release study of implantable materials.

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Section: Introductionmentioning

confidence: 99%

Comparison of Three Dissolution Apparatuses for Testing Calcium Phosphate Pellets used as Ibuprofen Delivery Systems

Chevalier

Viana

Artaud³

et al. 2009

AAPS PharmSciTech

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“…31,32 In the present study, degradation of wnf-CPC was observed through the 12-week implantation in bone defects of rabbit femora. As the implantation time prolonged, new bone regenerated and gradually penetrated into the pores of the implants, accompanied by the resorption of the implanted materials.…”

Section: Figurementioning

confidence: 57%

Wollastonite nanofiber–doped self-setting calcium phosphate bioactive cement for bone tissue regeneration

Guo¹,

Wei²,

Song³

et al. 2012

IJN

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Abstract:The purpose of this study was to synthesize a self-setting bioactive cement by incorporation of wollastonite nanofibers (WNFs) into calcium phosphate cement (CPC). The composition, morphology, setting time, compressive strength, hydrophilicity, and degradation of WNF-doped CPC (wnf-CPC) were investigated. Scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, and inductively coupled plasma atomic emission spectroscopy were utilized. Additionally, methyl-thiazolyl-tetrazolium bromide assay, scanning electron microscopy, inductively coupled plasma atomic emission spectroscopy, and histological evaluation were used to study the cell and tissue responses to wnf-CPC, both in vitro and in vivo. The results confirmed that the addition of WNFs into CPC had no obvious effect on the setting time or the compressive strength of wnf-CPC, provided the WNF amount was not more than 10 wt%. However, the hydrophilicity and degradability of wnf-CPC were significantly improved by the addition of WNFs -this was because of the change of microstructure caused by the WNFs. The preferred dissolution of WNFs caused the formation of microporosity in wnf-CPC when soaked in tris hydrochloride solution. The microporosity enlarged the surface area of the wnf-CPC and so promoted degradation of the wnf-CPC when in contact with liquid. In addition, MG-63 cell attachment and proliferation on the wnf-CPC were superior to that on the CPC, indicating that incorporation of WNFs into CPC improved the biological properties for wnf-CPC. Following the implantation of wnf-CPC into bone defects of rabbits, histological evaluation showed that wnf-CPC enhanced the efficiency of new bone formation in comparison with CPC, indicating excellent biocompatibility and osteogenesis of wnf-CPC. In conclusion, wnf-CPC exhibited promising prospects in bone regeneration.

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“…Tazaki et al 38) suggested that the resorbable -TCP block may be an effective with that by HA has been reported 39) . In addition, osteoclasts formed from monocyte lineage cells with TCP had less TRAP activity than HA, but the pits formed were deeper 40) . -TCP particles might lead to lower rates of monocyte linage cell differentiation and osteoclastogenesis and subsequent particleinduced inflammation and bone resorption.…”

Section: E M O N S T R a T E D V E Gf S C A Ff O L D S C O U L D E mentioning

confidence: 95%

Optimal Diameter of Honeycomb Tunnel Structure induces Bone Regeneration and Metabolism by Promoting Angiogenesis for an Implant Circumference Bone Defect

Shirota

Shintani

Yoshizawa

et al. 2013

J. Hard Tissue Biology.

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To develop an effective method of bone augmentation for dental implants, particularly for patients with a scarce amount of bone, we introduced a new honeycomb-like -tricalcium phosphate (H--TCP) as a scaffold, whose unique geometrical properties induce bone formation along with vasculature. A total of six beagles from 6 to 7 years old were used for this study. Autologous bone marrow-derived mesenchymal cells (BMC) cultured with H--TCP were implanted around the dental implants, and healing was compared with conventional bone augmentation using autogenous bone. The 2-wall peri-implant defects were filled with the scaffold material pre-coated with BMP-2 and cultured with BMCs. Judging from the surface contact area between the bone and the implant, at 12 weeks the highest bone formation was found in the experimental group using the BMP-2 coated H--TCP with BMCs. This was significantly higher than the control H--TCP with BMP-2-coating but without BMC. It was noted that within the tunnels of the implanted H--TCP, one or two blood vessels with a diameter of 50-100 micro meter were generated in most cases after 2 weeks. These results suggested that the geometry of the honeycomb like -TCP with, gave advantages in terms of initial induction of blood vessel formation which is essential for bone augmentation.

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Formation of osteoclast-like cells on HA and TCP ceramics

Cited by 164 publications

References 22 publications

Comparison of Three Dissolution Apparatuses for Testing Calcium Phosphate Pellets used as Ibuprofen Delivery Systems

Comparison of Three Dissolution Apparatuses for Testing Calcium Phosphate Pellets used as Ibuprofen Delivery Systems

Wollastonite nanofiber–doped self-setting calcium phosphate bioactive cement for bone tissue regeneration

Optimal Diameter of Honeycomb Tunnel Structure induces Bone Regeneration and Metabolism by Promoting Angiogenesis for an Implant Circumference Bone Defect

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Formation of osteoclast-like cells on HA and TCP ceramics

Cited by 164 publications

References 22 publications

Comparison of Three Dissolution Apparatuses for Testing Calcium Phosphate Pellets used as Ibuprofen Delivery Systems

Comparison of Three Dissolution Apparatuses for Testing Calcium Phosphate Pellets used as Ibuprofen Delivery Systems

Wollastonite nanofiber&ndash;doped self-setting calcium phosphate bioactive cement for bone tissue regeneration

Optimal Diameter of Honeycomb Tunnel Structure induces Bone Regeneration and Metabolism by Promoting Angiogenesis for an Implant Circumference Bone Defect

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Product

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About

Wollastonite nanofiber–doped self-setting calcium phosphate bioactive cement for bone tissue regeneration