Formation of Oriented Helical Peptide Layers on a Gold Surface Due to the Self-Assembling Properties of Peptides

Miura, Yoshiko; Kimura, Shunsaku; Imanishi, Yukio; Umemura, Junzo

doi:10.1021/la981296d

Cited by 120 publications

(158 citation statements)

References 35 publications

(37 reference statements)

Supporting

Mentioning

142

Contrasting

Order By: Relevance

“…The tilt angles of the helices from the surface normal were estimated to be 63°, 43°, and 40°for the 8mer, 16mer, and 24mer, respectively, from the ratio of the amide I and II absorbances. This result suggests that stronger intermolecular hydrophobic and van der Waals interactions among longer helical peptides should align the helices parallel to each other, resulting in more vertical orientation on the surface [27]. On the basis of the tilt angles and the molecular lengths, the monolayer thicknesses were estimated to be 14, 28, and 38Å for the 8mer, 16mer, and 24mer SAMs, respectively.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Distance dependence of long‐range electron transfer through helical peptides

Kai

Takeda

Morita

et al. 2007

Journal of Peptide Science

Self Cite

View full text Add to dashboard Cite

Helical peptides of 8mer, 16mer, and 24mer carrying a disulfide group at the N -terminal and a ferrocene moiety at the C-terminal were synthesized, and they were self-assembled on gold by a sulfur-gold linkage. Infrared reflection-absorption spectroscopy and ellipsometry confirmed that they formed a monolayer with upright orientation. Cyclic voltammetry showed that the electron transfer from the ferrocene moiety to gold occurred even with the longest 24mer peptide. Chronoamperometry and electrochemical impedance spectroscopy were carried out to determine the standard electron transfer rate constants. It was found that the dependence of the electron-transfer rates on the distance was significantly weak with the extension of the chain from 16mer to 24mer (decay constant β = 0.02-0.04). This dependence on distance cannot be explained by an electron tunneling mechanism even if increased hydrogen-bonding cooperativity or molecular dynamics is considered. It is thus concluded that this long-range electron transfer is operated by an electron hopping mechanism.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The number of interferogram accumulations was 500. Molecular orientation of the peptide monolayer was examined from the amide I/II absorbance ratio in the spectrum according to Eqn (2) assuming uniform orientation of the helix axis around the surface normal [26,27].…”

Section: Characterization Of Monolayersmentioning

confidence: 99%

Distance dependence of long‐range electron transfer through helical peptides

Kai

Takeda

Morita

et al. 2007

Journal of Peptide Science

Self Cite

View full text Add to dashboard Cite

show abstract

“…3 Compounds such as 1,2-dithiolane-3-pentanoic acid (also known as thioctic acid, lipoic acid, or 1,2-dithiolane-3-valeric acid) have been used for various applications such as molecular switches, molecular machines, sensors, and protein immobilization. [4][5][6][7][8][9][10][11][12][13][14] A prominent example is the bistable Stoddart-Heath-type [2]rotaxane (1) anchored to gold electrodes, 4,15 which has already proved useful as a molecular switch. 15,16 The switch 1 is turned on and off reversibly upon the redoxinduced shuttling of the cyclobis-(paraquat-p-phenylene) (CB-PQT, blue) ring between two stations, tetrathiafulvalene (TTF, green) and 1,5-dioxynaphthalene (DNP, red).…”

Section: Introductionmentioning

confidence: 99%

Electron Transport through Cyclic Disulfide Molecular Junctions with Two Different Adsorption States at the Contact: A Density Functional Theory Study

Jang

Goddard

2008

J. Phys. Chem. C

View full text Add to dashboard Cite

1,2-Dithiolane is a promising anchor group for attaching molecules to metal electrodes in molecular junction devices. This five-membered cyclic disulfide adsorbs on Au surfaces either in a cyclic fashion (with its disulfide bond intact, via molecular adsorption) or in an acyclic fashion (with its disulfide bond broken, via dissociative adsorption). Our density functional theory calculations show that the dissociative adsorption is slightly preferred, but both are stable. We also report nonequilibrium Green's function calculations showing that molecular junctions of cyclic and acyclic 1,2-dithiolanes sandwiched between two gold electrodes exhibit essentially the same insulating current-voltage characteristics at moderate bias voltages, despite the significant difference in their states of adsorption.

show abstract

“…To this end we linked polypeptide SAMs to the GaAs surface of the PCM. The polypeptide molecule is composed of eight alternating (Ala-Aib) sequences with a Glutamic acid (Glu) attached to the C-terminal of the peptide and is stable in α-helix form [22]. The peptide chemically binds to the GaAs surface by a carboxyl group located in the Glu amino acid.…”

mentioning

confidence: 99%

Frequency control of photonic crystal membrane resonators by monolayer deposition

Strauf

Rakher

Carmeli

et al. 2006

Applied Physics Letters

View full text Add to dashboard Cite

We study the response of GaAs photonic crystal membrane resonators to thin film deposition. Slow spectral shifts of the cavity mode of several nanometers are observed at low temperatures, caused by cryo-gettering of background molecules. Heating the membrane resets the drift and shielding will prevent drift altogether. In order to explore the drift as a tool to detect surface layers, or to intentionally shift the cavity resonance frequency, we studied the effect of self-assembled monolayers of polypeptide molecules attached to the membranes. The 2 nm thick monolayers lead to a discrete step in the resonance frequency and partially passivate the surface.Photonic crystal membrane microcavities (PCM) are promising candidates for applications ranging from quantum and classical communication [1], to microlasers [2,3] and sensing devices [4,5]. Due to their ultra small mode volumes [6] and large surface to volume ratio, the PCM resonant frequency is highly sensitive to its environment. While this sensitivity may be exploited for novel sensing applications, it complicates solid-state cavity quantum electrodynamic (QED) experiments that depend on a precise resonance condition between a cavity mode and an embedded single quantum dot (QD) [7,8,9, 10], single atom [11] or single impurity [12]. This paper describes a slow red-shift of the PCM mode emission frequency that can occur at low operation temperatures. We ascribe this shift to molecular condensation on the PCM surface. We further describe methods used to fully curtail the drift, and in addition, we report on the first demonstration of a controlled red-shift of the PCM mode by the adsorption of a self-assembled monolayer (SAM) of polypeptide molecules.We are particularly interested in PCM devices operated at low temperatures in such a way that embedded QDs display a discrete energy spectrum. As a model system a square-lattice PCM geometry with one missing air hole (S1) has been chosen, which is known to confine the fundamental mode in the proximity of the air-semiconductor interface [13]. A single layer of selfassembled InAs QDs was embedded in the 180 nm thick GaAs membrane and emits around 950 nm [14] under non-resonant laser excitation at 780 nm. Figure 1a shows a spectrum of the fundamental cavity mode taken at pump powers of 15 µW, which has been recorded with a micro photoluminescence (micro-PL) setup [15]. At these excitation conditions the cavity mode is clearly visible at 1.3293 eV with a quality factor (Q-factor) of 1900. The 2 µm diameter laser excitation spot has to be positioned with an accuracy of ±0.5 µm with respect to the cavity defect region (Fig. 1c), demonstrating the strongly localized character of the mode. Individual QD transitions are visible under low pump power excitation of 50 nW, which have been identified by their pronounced antibunching signature (not shown). Another set of two spectra was taken 200 min later as shown in Fig. 1b. While the single QD emission energy at 1.31780 ± 2 · 10 −5 eV did not change in the entire observation perio...

show abstract

Formation of Oriented Helical Peptide Layers on a Gold Surface Due to the Self-Assembling Properties of Peptides

Cited by 120 publications

References 35 publications

Distance dependence of long‐range electron transfer through helical peptides

Distance dependence of long‐range electron transfer through helical peptides

Electron Transport through Cyclic Disulfide Molecular Junctions with Two Different Adsorption States at the Contact: A Density Functional Theory Study

Frequency control of photonic crystal membrane resonators by monolayer deposition

Contact Info

Product

Resources

About