Formation of monodisperse microbubbles in a microfluidic device

Microdroplet formation of water and nanofluids in heat-induced microfluidic T-junction

“…Although several studies (Song et al 2006;Xu et al 2006aXu et al , 2006bGarstecki et al 2006) discussed the droplet formation process at T-junction, it will be briefed in this subsection for easy understanding by non-microfluidic researchers such as those working on nanofluids.…”

“…Geometrical techniques have been used to create droplets of various sizes and size distributions (Link et al 2004). In microfluidics, T-junction microchannel is one of the most frequently used configurations for droplet formation and manipulation (Thorsen et al 2001;Nisisako et al 2002;Xu et al 2006aXu et al , 2006b. The wide usage of this T-junction geometry is due to the ease of droplet formation and uniformity of the formed droplets.…”

Experimental study of microbubble coalescence in a T-junction microfluidic device

“…The average diameters of generated bubbles were in the range of 362-543 and 492-626 lm, when using the microchannel with main channel width of 0.6 and 0.8 mm, respectively. The polydispersity index of bubble diameters at every operating condition, which is defined as the ratio of the relative deviation of bubble size to the average bubble diameter, was less than 3%, so it indicates the microbubbles are highly uniform (Xu et al 2006a). Flows of both phases were consistent in the two generators for equal-sized bubbles in collision.…”

Monodisperse Microbubbles as Drug Carrier Units Having the Olive Oil as the Coating Layer from Devices Manufactured by 3D Printing

“…Micro bubbles as carriers of pharmacologically active compounds represent one of the most promising frontiers of modern medicine having great potential to revolutionize disease treatment, specifically where the high concentration of drugs administered systematically causes undesirable side effects to the patient. Currently, many researches on this subject are underway, seeking to improve micro bubble production techniques by looking for new biocompatible coating matrices [4][5][6][7][8][9][10] and at the same time satisfies the prerequisites of stability and ability to withstand the aggressions of the environment in which they will be dispersed. The feasibility of this new modality of treatment involves the development of techniques of manufacture of generators, accessible and, at the same time, able to generate uniform and stable micro bubbles with sizes compatible with clinical applications, i.e.…”