Formation of Macular Inner Nuclear Layer Cysts in Optic Atrophy

Jiramongkolchai, Kim; Bhatti, M. Tariq; Proia, Alan D.; Freedman, Sharon F.; El-Dairi, Mays

doi:10.1167/iovs.15-18814

Cited by 6 publications

(2 citation statements)

References 13 publications

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“…In patients with optic atrophy, the INL microcysts were also dominantly located at the papillomacular bundle area 12 . The authors proposed that the cell volume loss in the ganglion cell layer and thinning of the nerve fiber layer make the INL expand vertically to compensate for the space created by the vitreous traction, hence the formation of microcysts.…”

Section: Discussionmentioning

confidence: 96%

Inner Nuclear Layer Microcyst Configuration, Distribution, and Visual Prognosis in Patients With Epiretinal Membrane After Vitrectomy and Membrane Peeling

Hsieh

Chou

Huang

et al. 2019

Sci Rep

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Inner nuclear layer(INL) microcysts at central macula are a common finding in patients with epiretinal membrane (ERM) after vitrectomy and membrane peeling. Using en face mode of optical coherence tomography (OCT) angiography, patients with ERM after surgery were retrospectively reviewed to understand the configuration and distribution of microcysts as well as their impact on visual acuity. Forty-six eligible patients were enrolled and their baseline best-corrected visual acuities improved from 20/67 to 20/29 (P < 0.01) after surgery. Twenty-eight (60.9%) patients had microcysts that appeared at a median of 5 months after the surgery and persisted for mean 16 months follow-up. The microcyst appeared as spheroidal shape with length ranged from 20 to 80 μm and widths of 80 μm in average. They tend to group in cluster with a density of 245 microcysts per mm 2 . The frequency of microcyst distribution was 86%, 54%, 32%, 25% and 18% at the nasal, superior, inferior, temporal quadrants and central 1 mm, respectively. Linear regression analysis showed that INL microcysts at central and temporal quadrants were associated with poorer visual acuity (P = 0.02 and P = 0.01, respectively). The presence of INL microcysts in center subfield and involved wider area is a poor prognostic factor for visual outcomes.

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Section: Discussionmentioning

confidence: 96%

Inner Nuclear Layer Microcyst Configuration, Distribution, and Visual Prognosis in Patients With Epiretinal Membrane After Vitrectomy and Membrane Peeling

Hsieh

Chou

Huang

et al. 2019

Sci Rep

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“…In noninflammatory optic neuropathies including dominant optic atrophy and Leber hereditary optic neuropathy, cysts in the INL are thought to be due to transsynaptic degeneration [30]. Moreover, cysts seem to be more prevalent in younger patients with an intact vitreous base, suggesting that vitreous traction may have a role in CSs development [30].…”

Section: Discussionmentioning

confidence: 99%

Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces

et al. 2021

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Cystoid spaces (CSs) are a common retinal finding in choroideremia (CHM) patients. The aim of this study was to analyze the vascular features of the choroid associated with the presence of CSs in patients with confirmed genetic diagnosis of CHM. A total of 33 patients (33 eyes) were enrolled in this retrospective cross-sectional study and divided into two groups based on the presence (17 eyes) or absence (16 eyes) of CSs. Choroidal features were evaluated on spectral-domain optical coherence tomography including subfoveal choroidal thickness (CT), total choroidal area (TCA), luminal choroidal area (LCA), and stromal choroidal area (SCA). The choroidal vascularity index (CVI) was then calculated in all study eyes. All structural choroidal parameters were calculated both on the entire length of the B-scan and in the central subfoveal 1500 μm. The average age was 37.3 ± 11.6 and 31.4 ± 16.7 years (p = 0.25) and mean logMAR best-corrected visual acuity was 0.11 ± 0.20 and 0.20 ± 0.57 (p = 0.54) in the CHM groups with and without CSs, respectively. There were no significant differences in subfoveal CT, and TCA, LCA, SCA, and CVI evaluated on either the entire scan or in the central 1500 μm (all p > 0.05). All choroidal vasculature parameters exhibited no significant differences between CHM eyes with and without CSs. Our results suggest that the choroid may not be involved in the development of CSs in patients with CHM.

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Subclinical Retinal versus Brain Findings in Infants with Hypoxic Ischemic Encephalopathy

Mangalesh

Tran-Viet

Pizoli

et al. 2020

Graefes Arch Clin Exp Ophthalmol

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Formation of Macular Inner Nuclear Layer Cysts in Optic Atrophy

Cited by 6 publications

References 13 publications

Inner Nuclear Layer Microcyst Configuration, Distribution, and Visual Prognosis in Patients With Epiretinal Membrane After Vitrectomy and Membrane Peeling

Inner Nuclear Layer Microcyst Configuration, Distribution, and Visual Prognosis in Patients With Epiretinal Membrane After Vitrectomy and Membrane Peeling

Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces

Subclinical Retinal versus Brain Findings in Infants with Hypoxic Ischemic Encephalopathy

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