Formation of ion clusters by low-energy electrons in nanometric targets: experiment and Monte Carlo simulation

Bantsar, A.; Großwendt, B.; Pszona, S.

doi:10.1093/rpd/ncl406

Cited by 13 publications

(8 citation statements)

References 3 publications

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“…Experimental results have been published for alpha particles ( 241 Am) (Pszona et al 2000), low energy electrons (Bantsar et al 2009), 125 I Auger electrons (Pszona et al 2012), and carbon ions (Bantsar et al 2014(Bantsar et al , 2015. Of note, the Polish research group also compared their experimental results with those obtained by Monte Carlo simulations (Bantsar et al 2006.…”

Section: Experimental Nanodosimetrymentioning

confidence: 99%

Applications of nanodosimetry in particle therapy planning and beyond

Ruciński¹,

Biernacka²,

Schulte³

2021

Phys. Med. Biol.

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This topical review summarizes underlying concepts of nanodosimetry. It describes the development and current status of nanodosimetric detector technology. It also gives an overview of Monte Carlo track structure simulations that can provide nanodosimetric parameters for treatment planning of proton and ion therapy. Classical and modern radiobiological assays that can be used to demonstrate the relationship between the frequency and complexity of DNA lesion clusters and nanodosimetric parameters are reviewed. At the end of the review, existing approaches of treatment planning based on relative biological effectiveness (RBE) models or dose-averaged linear energy transfer are contrasted with an RBE-independent approach based on nandosimetric parameters. Beyond treatment planning, nanodosimetry is also expected to have applications and give new insights into radiation protection dosimetry.

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Section: Experimental Nanodosimetrymentioning

confidence: 99%

Applications of nanodosimetry in particle therapy planning and beyond

Ruciński¹,

Biernacka²,

Schulte³

2021

Phys. Med. Biol.

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“…The JC is a gas-based detection system developed in the National Centre for Nuclear Research, Poland, to measure the number of ionizations produced in SV by the passage of a single charged particle, e.g., electron or heavy-ion (Pszona et al 2000, Bantsar 2010, Bancer et al 2020. A schematic illustration of the JC detector is shown in figure 1(a).…”

Section: Nanodosimetric Measurements With Jet Countermentioning

confidence: 99%

“…Depending on the gas pressure, the equivalent diameter of cylinder chamber (further referred as target size) may vary ranging from 1 to 10 nm allowing investigation of ICSD in SV of different size. Between existing nanodosimeters, the JC offers studying the broadest range of target size and is capable of measuring ICSD for low energy electrons (Bantsar et al 2006(Bantsar et al , 2009.…”

Section: Nanodosimetric Measurements With Jet Countermentioning

confidence: 99%

Geant4-DNA modeling of nanodosimetric quantities in the Jet Counter for alpha particles

et al. 2021

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The purpose of this work was to validate the calculation accuracy of nanodosimetric quantities in Geant4-DNA track structure simulation code. We implemented the Jet Counter (JC) nanodosimeter geometry in the simulation platform and quantified the impact of the Geant4-DNA physics models and JC detector performance on the ionization cluster size distributions (ICSD). ICSD parameters characterize the quality of radiation field and are supposed to be correlated to the complexity of the initial DNA damage in nanoscale and eventually the response of biological systems to radiation. We compared Monte Carlo simulations of ICSD in JC geometry performed using Geant4-DNA and PTra codes with experimental data collected for alpha particles at 3.8 MeV. We investigated the impact of simulation and experimental settings, i.e., three Geant4-DNA physics models, three sizes of a nanometer sensitive volume, gas to water density scaling procedure, JC ion extraction efficiency and the presence of passive components of the detector on the ICSD and their parameters. We found that ICSD in JC geometry obtained from Geant4-DNA simulations in water correspond well to ICSD measurements in nitrogen gas for all investigated settings, while the best agreement is for Geant4-DNA physics option 4. This work also discusses the accuracy and robustness of ICSD parameters in the context of the application of track structure simulation methods for treatment planning in particle therapy.

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“…To date, three types of nanodosimeter have been developed that measure frequency distribution of ionisation cluster size in a gas, where the respective target volumes correspond to different sizes of nanometric targets in biological matter. The Jet Counter at NCBJ detects positive ions produced by primary particles passing centrally through a pulse of nitrogen gas simulating biological target sizes of about 2 nm and 20 nm by adjusting the density of molecules [17,18]. The StarTrack Counter at INFN detects electrons generated in a sensitive volume of propane equivalent to a 20 nm biological target intersected by the primary particle track at a defined distance from the target centre [19,20].…”

Section: Nanodosimetrymentioning

confidence: 99%

Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

Rabus

Hilgers

Sharpe

et al. 2014

EPJ Web of Conferences

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Abstract. Funded within the European Metrology Research Programme (EMRP) [1], the joint research project "Biologically weighted quantities in radiotherapy" (BioQuaRT) [2] aims to develop measurement and simulation techniques for determining the physical properties of ionising particle tracks on different length scales (about 2 nm to 10 μm), and to investigate the correlation of these track structure characteristics with the biological effects of radiation at the cellular level. Work package 1 develops micro-calorimeter prototypes for the direct measurement of lineal energy and will characterise their response for different ion beams by experiment and modelling. Work package 2 develops techniques to measure particle track structure on different length scales in the nanometre range as well as a measurement device integrating a silicon microdosimeter and a nanodosimeter. Work package 3 investigates the indirect effects of radiation based on probes for quantifying particular radical and reactive oxygen species (ROS). Work package 4 focuses on the biological aspects of radiation damage and will produce data on initial DNA damage and late effects for radiotherapy beams of different qualities. Work package 5 provides evaluated data sets of DNA cross-sections and develops a multi-scale model to address microscopic and nanometric track structure properties. The project consortium includes three linked researchers holding so-called Researcher Excellence Grants, who carry out ancillary investigations such as developing and benchmarking a new biophysical model for induction of early radiation damage and developing methods for the translation of quantities derived from particle track structure to clinical applications in ion beam therapy.

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Formation of ion clusters by low-energy electrons in nanometric targets: experiment and Monte Carlo simulation

Cited by 13 publications

References 3 publications

Applications of nanodosimetry in particle therapy planning and beyond

Applications of nanodosimetry in particle therapy planning and beyond

Geant4-DNA modeling of nanodosimetric quantities in the Jet Counter for alpha particles

Biologically Weighted Quantities in Radiotherapy: an EMRP Joint Research Project

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