Formation of Gold Nanoparticles inside a Hydrogel by Multiphoton Photoreduction for Plasmonic Sensing

Last Advances on Hydrogel Nanoparticles Composites in Medicine: An Overview with Focus on Gold Nanoparticles

“…It demonstrated good results also in the detection of biotin-streptavidin interaction, up to picomolar concentrations in the case of both LPSR and PEF detection, decreasing the limit of detection compared to a blank sample (Figure 5). [65,127] The versatility of PEGMA hydrogels has been also exploited for Reproduced under terms of the CC-BY license. [65] © 2022, The Authors, Advanced Materials Technologies published by Wiley-VCH GmbH biosensing applications and for tuning the diffusivity of molecules inside the gel matrix.…”

“…This may be due to the urea ability to act as H-bonds breaker, which promoted the mesh size increase of the hydrogel, hence a higher dispersion of the Au NPs, resulting in a blue-shift of the LSPR peak. [127] Among others, SERS represents an up-to-date technique employed for several applications, thanks to the augmented sensitivity that plasmonic structures can give for the detection of small quantities of analytes. [128] In this perspective, hydrogels combined with metal NPs have attracted attention as support for SERS platforms, since they can prevent NPs aggregation and promote the analyte diffusion inside the network, thanks to their physico-chemical properties.…”

“…The system was used for the detection of compounds contained in the sweat, but it demonstrated to be effective only for urea. This may be due to the urea ability to act as H‐bonds breaker, which promoted the mesh size increase of the hydrogel, hence a higher dispersion of the Au NPs, resulting in a blue‐shift of the LSPR peak [127] …”