Formation of food aversions in cancer patients receiving repeated infusions of chemotherapy

Jcobsen, Paul B.; Bovbjerg, Dana H.; Schwartz, Marc D.; Andrykowski, Michael A.; Futterman, Ann D.; Gilewski, Teresa; Norton, Larry; Redd, William H.

doi:10.1016/0005-7967(93)90004-e

Cited by 45 publications

(24 citation statements)

References 30 publications

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“…For example, distressed individuals often have appetite disturbances or dietary changes such as eating meals of lower nutritional value (Grunberg & Straub, 1992). If eating habits change because of treatment (e.g., food restriction with nausea or taste aversions from chemotherapy; Broeckel et al, 2000;Jacobsen et al, 1995), vulnerability may be heightened. In contrast, some cancer patients, particularly breast cancer patients receiving adjuvant chemotherapy, are at risk for weight gain (Camoriano, Loprinizi, & Ingle, 1990), perhaps because of changed metabolic requirements (Denmark-Wahnefried et al, 1997).…”

Section: Health Behaviorsmentioning

confidence: 99%

Biobehavioral outcomes following psychological interventions for cancer patients.

Andersen¹

2002

Journal of Consulting and Clinical Psychology

188

132

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Psychological interventions for adult cancer patients have primarily focused on reducing stress and enhancing quality of life. However, there has been expanded focus on biobehavioral outcomeshealth behaviors, compliance, biologic responses, and disease outcomes-consistent with the Biobehavioral Model of cancer stress and disease course. The author reviewed this expanded focus in quasi-experimental and experimental studies of psychological interventions, provided methodologic detail, summarized findings, and highlighted novel contributions. A final section discussed methodologic issues, research directions, and challenges for the coming decade.Cancer remains a significant national problem, with over 1 million Americans diagnosed each year. The adjustment process for cancer survivors may be burdensome and lengthy, and deteriorations in quality of life are underscored if they also have adverse health effects. A previous review noted the significant quality-of-life gains that can be achieved with psychological interventions (Andersen, 1992), a conclusion echoed here. In this review, I look more broadly and include biobehavioral responses and disease outcomes as areas important for intervention efforts. Although there are proportionately fewer studies that have included the latter, multimodal interventions and assessment of psychological, behavioral, and biologic mechanisms are the pathways for future research.The Biobehavioral Model of cancer stress and disease course (Andersen, Kiecolt-Glaser, & Glaser, 1994) provides the organizational framework for the discussion. Represented in Figure 1, the model includes psychological (e.g., stress and quality of life), behavioral (e.g., health behaviors and compliance), and biologic (e.g., neuroendocrine and immune) components and specifies the pathways by which health outcomes (e.g., disease endpoints-recurrence, disease free interval) might be affected. A complete discussion of the model is available elsewhere , as only brief summaries are provided prior to each section.Studies conducted since 1992 with adult cancer patients are reviewed; selected investigations prior to that period are included because of their importance, novelty, or absence from the earlier article focusing on quality of life (Andersen, 1992). Each component of the model is considered as an outcome following psychological interventions. Prior to each, I review descriptive findings and highlight prominent correlational investigations. For all experimental studies, accrual and retention rates and patient characteristics are provided, as these areas are in need of methodologic attention, as discussed later in the article. Although tedious at times, specific techniques of interventions are provided to enable the reader to distinguish among those with similar labels. Quasi-experimental designs are included for emerging areas. With few exceptions, all studies included psychological outcomes, but in the first section, I focus on studies with only these endpoints. Figure 1). Cancer survivors report con...

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Section: Health Behaviorsmentioning

confidence: 99%

Biobehavioral outcomes following psychological interventions for cancer patients.

Andersen¹

2002

Journal of Consulting and Clinical Psychology

188

132

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“…This model has been widely used to investigate behavioral and neural mechanisms of taste-visceral integration, learning, and memory and to identify therapeutic targets for clinical conditions such as cancer anorexia (Bernstein, 1985(Bernstein, , 1999Jacobsen et al, 1993;Rodriguez, Lopez, Symonds, & Hall, 2000;Welzl, D'Adamo, & Lipp, 2001).…”

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confidence: 99%

Temporal and Qualitative Dynamics of Conditioned Taste Aversion Processing: Combined Generalization Testing and Licking Microstructure Analysis.

Baird

John

Nguyen

2005

Behavioral Neuroscience

133

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The pattern of licking microstructure during various phases of a conditioned taste aversion (CTA) was evaluated. In Experiment 1, rats ingested lithium chloride (LiCl) for 3 trials and were then offered sodium chloride (NaCl) or sucrose on 3 trials. A CTA to LiCl developed and generalized to NaCl but not to sucrose. CTA intake suppression was characterized by reductions in burst size, average ingestion rate, and intraburst lick rate, and increases in brief pauses and burst counts. Compared with previous studies, LiCl licking shifted from a pattern initially matching that for normally accepted NaCl to one matching licking for normally avoided quinine hydrochloride by the end of the 1st acquisition trial. In Experiment 2, a novel paradigm was developed to show that rats expressed CTA generalization within 9 min of their first LiCl access. These results suggest that licking microstructure analysis can be used to assay changes in hedonic evaluation caused by treatments that produce aversive states.

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“…Since the amygdala also seems to be involved in conditioned taste aversion in humans, it is possible that the acquisition of this learning requires biological mechanisms that are common in different species of vertebrates [18]. Moreover, because the food aversion associated with chemotherapy treatment is similar to the experimentally induced taste aversion [19], the CTA paradigm has helped to develop different strategies for dealing with the taste aversion that occurs in patients being treated with chemotherapy [20].…”

Section: Description Of the Conditioned Taste Aversion Paradigmmentioning

confidence: 99%

Amygdala and Taste Learning

Molero‐Chamizo¹

2012

The Amygdala - A Discrete Multitasking Manager

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Formation of food aversions in cancer patients receiving repeated infusions of chemotherapy

Cited by 45 publications

References 30 publications

Biobehavioral outcomes following psychological interventions for cancer patients.

Biobehavioral outcomes following psychological interventions for cancer patients.

Temporal and Qualitative Dynamics of Conditioned Taste Aversion Processing: Combined Generalization Testing and Licking Microstructure Analysis.

Amygdala and Taste Learning

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