Abstract:Metabolic correlation between nucleotide biogenesis and vitamin B12 have been reported and discussed by many investigators since the discovery of vitamin B12 in 1948 (1-2).In 1954, Rege et al. (3) reported that the DNA content of Lacto bacillus leichmannii might be proportionally variable to the amount of vitamin B12 added. Thereafter, in the microbioassay of vitamin B12, it has become well known that thymidine may be responsible for the growth of L. leichmannii even in the absence of vitamin B12.The present … Show more
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