Formation of Citrate in vivo Induced by Fluoroacetate Poisoning

Buffa, P.; Peters, R.C.

doi:10.1038/163914b0

Cited by 52 publications

(34 citation statements)

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“…Fluoroacetic acid acts as a poison by first being converted to ff uorocitric acid which then competitively inhibits the metabolism of citric acid by the tricarboxylic acid cycle (Buffa & Peters, 1949;LiCbecq & Peters, 1949;Lotspeich, Peters & Wilson, 1952). The ability of this inhibitor to stop zygote formation was accordingly investigated.…”

Section: Zygote Formation Under Anaerobic Conditionsmentioning

confidence: 99%

The Role of the Krebs Cycle in Conjugation in Escherichia coli K-12

Fisher

1957

Journal of General Microbiology

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Section: Zygote Formation Under Anaerobic Conditionsmentioning

confidence: 99%

The Role of the Krebs Cycle in Conjugation in Escherichia coli K-12

Fisher

1957

Journal of General Microbiology

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“…The continued synthesis of citrate without its further metabolism leads to the accumulation of this metabolite in large quantities in many tissues of the animal (4,3). It has been suggested that the rise in citrate concentration is primarily an expression of the metabolism of the individual organ.…”

Section: Discussionmentioning

confidence: 99%

The Relation of the Krebs Cycle to Viral Synthesis

Ackermann

Kurtz²

1951

Journal of Experimental Medicine

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A further study has been made of the relationship of reactions of the Krebs cycle to the propagation of influenza virus. By the administration of sublethal doses of sodium fluoroacetate which were found to increase the concentration of citrate in the mouse lung, it was possible to demonstrate a blocking of the citric acid cycle in that organ. Further, the intraperitoneal administration of these concentrations of fluoroacetate was found to inhibit markedly the propagation of influenza, Type A, virus in the lungs of mice. The inhibition was observed when the fluoroacetate was administered 15 minutes, 6 hours, or 12 hours after the mice were inoculated with virus. This effect was also demonstrable when the concentration of the viral inoculum was varied over a range of virus titers from 103.5 to 106.5. Sodium fluoroacetate was found to have no effect in vitro on the infectivity or hemagglutinating property of the virus. The significance of these findings with regard to chemotherapy and to the mechanism of viral synthesis is described.

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“…Leaf chlorosis, necrosis and suppression of seeding growth were reported in the plant Helianthus annus exposed to 6.5 mM sodium monofluoroacetate (Cooke, 1976). The compound is incorporated into fluoroacetyl coenzyme A, which is condensed with oxalacetate to form fluorocitrate, a process dubbed as ''lethal synthesis'' (Buffa and Peters, 1950). The intensity of HTL2 band was increased in Chlorella more than four-fold by sodium monofluoroacetate, reflecting a status of oxidative stress probably generated by the metabolic blockage.…”

Section: Preparations (Van Der Heijden Et Al 1986) Propyl Gallate mentioning

confidence: 99%