Formation of chitosan nanoparticles to encapsulate krill oil ( Euphausia superba ) for application as a dietary supplement

Haider, Junaid; Majeed, Hamid; Williams, Peter; Safdar, Waseem; Zhong, Fang

doi:10.1016/j.foodhyd.2016.08.020

Cited by 91 publications

(73 citation statements)

References 41 publications

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“…Moreover, n −3 PUFA content in KO extracted through the subcritical butane‐dimethyl ether method (up to 41.13%) was higher than that obtained via the subcritical butane method. The results showed the same trend as that of PLs (Figure a), since the n −3 PUFA occurs naturally in KO mostly in the form of PL (Haider, Majeed, Williams, Safdar, & Zhong, ).…”

Section: Resultssupporting

confidence: 61%

The comparison of krill oil extracted through ethanol–hexane method and subcritical method

Sun

Shi

Xue

et al. 2019

Food Science & Nutrition

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This study aimed to develop a safe method EH (ethanol–hexane) to extract two kinds of krill oil (KO) simultaneously and analyze their composition. Meanwhile, subcritical butane and subcritical butane‐dimethyl ether extraction were used to extract KO for analysis comparison. Folch method was used to extract total lipids. When the volume ratio of ethanol to hexane is 4:6, the separation effect of ethanol layer and hexane layer is best. At this condition, the EH method yielded similar amount of lipids (up to 97. 72% of total lipids) with subcritical butane extraction method (97.60%). The recovery rate of ethanol and hexane was 83.6% and 86.86%, respectively. KO in hexane layer and extracted by the subcritical butane method are abundant in astaxanthin (910 and 940 mg/kg respectively), while KO in the ethanol layer had the highest phospholipid (PL) content (47.34%), n−3 polyunsaturated fatty acids (PUFA) content (45.51%), and the lowest fluorine content (11.17 μg/g), making it a potential candidate in the nutraceutical and antioxidant industry.

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Section: Resultssupporting

confidence: 61%

The comparison of krill oil extracted through ethanol–hexane method and subcritical method

Sun

Shi

Xue

et al. 2019

Food Science & Nutrition

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“…En el espectro FTIR del quitosano (Figura 2b) se observaron los picos característicos de la molécula. A los 3450 cm -1 son correspondien-tes a la vibraciones de los grupos funcionales OH (Haider et al,. 2017).…”

Section: Resultados Y Discusiónunclassified

Generación de un protocolo para la síntesis de nanopartículas de quitosano cargadas con florfenicol a través del método de gelación iónica

Carmona¹,

Plaza²,

Recio‐Sánchez³

et al. 2018

Rev. investig. vet. Perú

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La formación de nanopartículas de quitosano mediante el método de gelación iónica tiene un alto potencial para la carga, transporte y liberación controlada de moléculas. Es un método sencillo y las nanopartículas presentan buena absorción, estabilidad, biocompatibilidad y baja toxicidad. El florfenicol es uno de los antibióticos más utilizados en la industria acuícola y es administrado mezclado con el alimento en altas concentraciones, lo cual genera problemas de dosis efectivas y de residuos no deseados. De esta manera, la síntesis de nanopartículas de quitosano (Q) cargadas con florfenicol podría otorgar ventajas a la hora de proteger, transportar y liberar de forma controlada el fármaco en peces de interés económico. En el presente estudio se sintetizaron nanopartículas de quitosano y tripolifosfato de sodio (TPP) con y sin florfenicol para evaluar su carga efectiva y liberación. Los resultados obtenidos con espectrometría FTIR corroboran la formación de las nanopartículas de Q-TPP con los cambios observados en los patrones de espectros infrarojo entre el quitosano matriz y las nanopartículas sintetizadas. Las nanopartículas de Q-TPP pueden cargar entre 48 y 50% de florfenicol en su interior. El ensayo de liberación in vitro del antibiótico mostró una liberación controlada y estable en el tiempo en condiciones de pH ácido y temperatura controlada de 15° C de hasta 10 días. Finalmente, se muestra que las nanopartículas de Q-TPP tienen potencial para atrapar y liberar de forma controlada el fármaco evaluado.

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“…Previous studies have shown that the lipid matrix and nature of the colloidal interactions operating between oil droplets considerably affects the stability of lipid nanoparticles [10][11][12][13][14][15][16][17][18][19][20]. In this study, wax-based NLCs were stabilized by Tween 80 and lecithin.…”

Section: Physical and Chemical Stabilitymentioning

confidence: 88%

“…FTIR spectroscopy was also used as a supplementary method to analyze the oxidative stability, evidencing the qualitative presence of primary and secondary oxidation products, according to Haider et al (2017) [14]. The samples were prepared by the pellet method with anhydrous KBr powder (1:100 lyophilized samples to KBr ratio).…”

Section: Oxidative Stability By Ftir Spectroscopymentioning

confidence: 99%

“…It was previously shown that during the oxidation process, the band in the hydroperoxides region widens and intensifies as the oxidation degree increases. However, the frequency value of this band may decrease with the progressive degradation of hydroperoxides [14,30]. Figure 5 illustrates the obvious spectral changes in the NLC spectra in the hydroperoxide region.…”

Section: Oxidative Stability By Ftir Spectroscopymentioning

confidence: 99%

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β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

et al. 2020

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The objective of the present study was to explore the potential of nanostructured lipid carriers (NLCs) for improving the oral delivery of β-sitosterol, a poorly water-soluble bioactive component with hypocholesterolemic activity. Two β-sitosterol formulations with different solid lipid compositions were prepared by melt emulsification, followed by the sonication technique, and the effect of storage conditions and simulated digestion on the physical, chemical and oxidative stability, bioaccessibility and release were extensively studied. Both NLC preparations remained relatively stable during the four weeks of storage at different conditions (4, 25 and 40 °C), with more superior stability at lower temperatures. The in vitro digestion experiment indicated a high physical stability after exposure to the simulated mouth and stomach stages and an improved overall β-sitosterol bioaccessibility at the end of the digestion. The NLCs presented an increased solubility and gradual release which could be justified by the remarkable affinity of β-sitosterol to the complex lipid mixture. An in vivo study demonstrated an improved reduction in the total cholesterol and low-density lipoprotein cholesterol plasma levels in mice compared with the drug suspension. These investigations evidenced the potential of the developed NLC formulations for the enhancement of solubility and in vivo performance of β-sitosterol.

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Formation of chitosan nanoparticles to encapsulate krill oil ( Euphausia superba ) for application as a dietary supplement

Cited by 91 publications

References 41 publications

The comparison of krill oil extracted through ethanol–hexane method and subcritical method

The comparison of krill oil extracted through ethanol–hexane method and subcritical method

Generación de un protocolo para la síntesis de nanopartículas de quitosano cargadas con florfenicol a través del método de gelación iónica

β-Sitosterol Loaded Nanostructured Lipid Carrier: Physical and Oxidative Stability, In Vitro Simulated Digestion and Hypocholesterolemic Activity

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