Formation of carbonated hydroxyapatite films on metallic surfaces using dihexadecyl phosphate–LB film as template

Antibacterial efficacy, corrosion resistance, and cytotoxicity studies of copper-substituted carbonated hydroxyapatite coating on titanium substrate

“…To further stimulate the bone-bonding ability, metallic implants are generally coated with osteoconductive biomaterials, such as hydroxyapatite (HAP, Ca 10 (PO 4 ) 6 (OH) 2 ) bioceramic [2,3]. Artificial synthetic HAP is extremely similar to the inorganic part of bones and the dentine of teeth, and it is non-toxic within any quantity and osteoconductive [4].…”

Biomedical applications of nanotechnology

“…We have reviewed the growth of homogeneous, nanostructured, and continuous carbonated-HAp coatings on titanium and stainless steel surfaces using dihexadecyl phosphate (DHP) LB films as template. We achieved hybrid coatings with high roughness and wettability, which increased the proliferation of osteoblasts (de Souza et al 2014b). Moreover, the LB technique allows the immobilization of different molecules (drugs, proteins) in the organic matrix as an alternative to building hybridbiofunctional coatings.…”

“…Manipulation of the immersion and withdrawal of the support through the monolayer creates LB films containing as many layers as desired. By judiciously choosing the amphiphilic molecules, Ca 2+ can interact with the molecule polar heads, which affords a well-ordered Ca 2+ array for biomineral growth after the biomineral is deposited on metallic surfaces (Costa and Maquis 1998;Zhang et al 2004;de Souza et al 2014b;. We have reviewed the growth of homogeneous, nanostructured, and continuous carbonated-HAp coatings on titanium and stainless steel surfaces using dihexadecyl phosphate (DHP) LB films as template.…”

“…However, there has been little exploration of the use of organic matrices to mediate the formation of hybrid coatings on metallic surfaces (Walsh et al 2001;Xia et al 2012). Two promising techniques involve templating biomineral coatings using Langmuir-Blodgett (LB) and layer-by-layer (LbL) films (de Souza et al 2014a;Cruz and Ramos 2016). LB films are structured molecular films of amphiphilic molecules and are a well-known biomembrane model used to understand and to mimic biological events (Caseli et al 2015).…”

Desenvolvimento de materiais bioinspirados contendo Sr²⁺ para modificação de superfícies de Ti

“…Dessa forma, é possível simular membranas biológicas 137 e estudar efeitos de íons 138,139 , proteínas 140 e fármacos 141 na estrutura e propriedades das monocamadas apropriadas, correlacionando-os com fenômenos biológicos. Em especial, monocamadas de Langmuir são uma importante ferramenta no estudo da influência da matriz orgânica na biomineralização 85,102,142,143 . A origem dessa aplicação está na ideia de que a nucleação da fase mineral em sistemas biológicos dá-se pela correspondência estrutural entre grupos funcionais da matriz orgânica e a estrutura cristalina dos núcleos minerais em formação 144 .…”