Formation of Calcium-Deficient Hydroxyapatite via Hydrolysis of Nano-Sized Pure α-Tricalcium Phosphate

Vecbiškena, Linda; Gross, Kārlis Agris; Riekstiņa, Una; Yang, Chieh

doi:10.4028/www.scientific.net/amr.1117.201

Cited by 2 publications

(4 citation statements)

References 6 publications

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“…Pure CaP biocement (CPB) formed hexagonal crystallites typical of CDHA derived from conventional CPBs. 27 Similar to the CDHA, the control cement (α-TCP) had a regular petal-like three-dimensional structure after culturing for 7 days at 100% relative humidity (Figure 7B). Concerning the control sample (PMA-tcp), Figure 7C shows that there was only a small amount of slice crystals on its surface.…”

Section: Scanning Electron Microscopymentioning

confidence: 76%

“…Pure CaP biocement (CPB) formed hexagonal crystallites typical of CDHA derived from conventional CPBs 27 . Similar to the CDHA, the control cement (α‐TCP) had a regular petal‐like three‐dimensional structure after culturing for 7 days at 100% relative humidity (Figure 7B).…”

Section: Resultsmentioning

confidence: 94%

“…inhibit α‐TCP hydrolysis by adsorbing to the surface of α‐TCP 17,26 . At the same time, exogenous Ca 2+ can exchange the cations from the α‐TCP surface and activate the hydraulic reaction, and α‐TCP is converted to CDHA gradually 27 . In the Ca 2+ → Cu 2+ /Sr 2+ exchange process, PMA can be crosslinked with metal ions to form a hydrogel‐coated surface.…”

Section: Methodsmentioning

confidence: 99%

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Enhanced osteogenic and bactericidal performance of premixed calcium phosphate cement with photocrosslinked alginate thin film

Shu,

Liao,

Wang

et al. 2024

J Biomedical Materials Res

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The increasing prevalence of implant‐associated infections (IAI) in orthopedics remains a public health challenge. Calcium phosphates (CaPs) are critical biomaterials in dental treatments and bone regeneration. It is highly desirable to endow CaPs with antibacterial properties. To achieve this purpose, we developed a photocrosslinked methacrylated alginate co‐calcium phosphate cement (PMA‐co‐PCPC) with antibacterial properties, using α‐tricalcium phosphate (α‐TCP) powders with 16% amorphous contents as solid phase, liquid phases containing CuCl2 and SrCl2 as an inhibitor, and CaCl2 as an activator to construct PCPC. When CaCl2 started to activate the hydration reaction, Sr2+ or Cu2+ ions were exchanged with Ca2+, and α‐TCP dissolution was restarted and gradually hydrated to form calcium‐deficient hydroxyapatite (CDHA). PMA was added to crosslink with Cu/Sr ions and form gel‐layer‐wrapped hydrated CDHA. This study explored the binding mechanism of PMA and PCPC and the ion release rule of Ca2+ → Sr2+/Cu2+, optimized the construction of several antibacterial PMA‐co‐PCPC materials, and analyzed the physical, chemical, and biological properties. Because of the combined effect of Cu and Sr ions, the scaffold exhibited a potential antibacterial activity, promoting bone formation and vascular regeneration. This work provides a basis for designing antibacterial calcium phosphate biomaterials with controllable treatment, which is an important characteristic for preventing IAI of biomaterials.

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Section: Scanning Electron Microscopymentioning

confidence: 76%

Section: Resultsmentioning

confidence: 94%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Enhanced osteogenic and bactericidal performance of premixed calcium phosphate cement with photocrosslinked alginate thin film

Shu,

Liao,

Wang

et al. 2024

J Biomedical Materials Res

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“…According to the Ostwald rule, the next most similar phase to ACP will crystallize, explaining why the α phase forms from the amorphous phase instead of the β phase. The α'-TCP phase is expected, but this is highly unstable at lower temperature, giving priority to the next high temperature allotrope, α-TCP [42]. β-TCP is not made directly from the amorphous phase.…”

Section: Amorphous Calcium Phosphate -The Transient State Before Crys...mentioning

confidence: 99%

Towards Biotechnological Processing of Calcium Phosphates

Gross

2015

AMR

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Transient or metastable phases offer an intermediate phase with additional flexibility for creating the end product. The processing pathway remains unknown when the final product is viewed. Biological processes frequently employ the amorphous phase as the transition phase. This is shown in mineralized tissues: invertebrates, pathological calcified deposits and murine fetal teeth. After a fast transition from an amorphous calcium phosphate to crystalline material, smaller changes occur over time. For an appreciation of the transition state, crystallinity is defined and measurement methods outlined. Biotechnology using transition material states offers fast, low temperature access to nanosized high temperature phases. Alfa tricalcium phosphate and apatite is made by a phase transition, but peroxyapatite requires long-range diffusion within the same structure. Tetracalcium phosphate is also possible, but this requires multiple transition states and phase decomposition. The pathway via the amorphous state offers an alternative route to biologically important materials.

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Formation of Calcium-Deficient Hydroxyapatite via Hydrolysis of Nano-Sized Pure α-Tricalcium Phosphate

Cited by 2 publications

References 6 publications

Enhanced osteogenic and bactericidal performance of premixed calcium phosphate cement with photocrosslinked alginate thin film

Enhanced osteogenic and bactericidal performance of premixed calcium phosphate cement with photocrosslinked alginate thin film

Towards Biotechnological Processing of Calcium Phosphates

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