Formation of Bis‐indolylmethanes from Symmetrical Triarylmethanes via Brønsted Acid Catalyzed C−C Bond Breaking Reaction
Nazir Uddin,
Sudipta Roy,
Sayantan Roy
et al.
Abstract:An alternative approach to synthesize bis‐indolylmethanes (BIMs) via a unique p‐toluenesulfonic acid (PTSA) catalyzed dual Csp3−Csp2 bond‐breaking reaction has been reported here. In the reported protocol, 1,3,5‐trimethoxybenzene (TMB), an electron‐rich and sterically bulky arene, acts as a carbon‐based leaving group which can be recovered after the completion of the reaction. In this process, several BIMs of various indole derivatives can be synthesized from symmetrical triarylmethanes (TRAMs) containing bis‐… Show more
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