Formation of ammonium in saline solution treated by nanosecond pulsed cold atmospheric microplasma: a route to fast inactivation of E. coli bacteria

Maheux, Simon; Duday, David; Belmonte, T.; Penny, Christian; Cauchie, Henry‐Michel; Clément, Franck; Choquet, Patrick

doi:10.1039/c5ra01109d

Cited by 30 publications

(33 citation statements)

References 26 publications

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“…This has been previously characterized in other studies1846474849. Process gas was either He, He/1% N 2 mixture or He/1% O 2 mixture at a 2 standard liters per minute (slm) flow rate.…”

Section: Methodsmentioning

confidence: 99%

Mechanistic insights into the impact of Cold Atmospheric Pressure Plasma on human epithelial cell lines

Dezest

Chavatte

Bourdens

et al. 2017

Sci Rep

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Compelling evidence suggests that Cold Atmospheric Pressure Plasma (CAPP) has potential as a new cancer therapy. However, knowledge about cellular signaling events and toxicity subsequent to plasma treatment is still poorly documented. The aim of this study was to focus on the interaction between 3 different types of plasma (He, He-O2, He-N2) and human epithelial cell lines to gain better insight into plasma-cell interaction. We provide evidence that reactive oxygen and nitrogen species (RONS) are inducing cell death by apoptosis and that the proteasome, a major intracellular proteolytic system which is important for tumor cell growth and survival, is a target of (He or He-N2) CAPP. However, RONS are not the only actors involved in cell death; electric field and charged particles could play a significant role especially for He-O2 CAPP. By differential label-free quantitative proteomic analysis we found that CAPP triggers antioxidant and cellular defense but is also affecting extracellular matrix in keratinocytes. Moreover, we found that malignant cells are more resistant to CAPP treatment than normal cells. Taken together, our findings provide insight into potential mechanisms of CAPP-induced proteasome inactivation and the cellular consequences of these events.

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“…This has been previously characterized in other studies1846474849. Process gas was either He, He/1% N 2 mixture or He/1% O 2 mixture at a 2 standard liters per minute (slm) flow rate.…”

Section: Methodsmentioning

confidence: 99%

Mechanistic insights into the impact of Cold Atmospheric Pressure Plasma on human epithelial cell lines

Dezest

Chavatte

Bourdens

et al. 2017

Sci Rep

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“…Hydroxyl radical is formed in the plasma phase by the interaction of surrounded air (especially water molecules) with plasma through (Zhang et al, 2015;Maheux et al, 2015) H 2 O* + H   OH  + H 2 (Maheux et al, 2015) H Van Gaens and Bogaerts, 2013;Gorbanev et al, 2016) A specific signature of our DBD configuration is hydrogen peroxide kinetics during activation. The literature generally states a linear increase in H 2 O 2 production with plasma exposure time , which is not the case here since the trend in Fig.…”

Section: Hydrogen Peroxidementioning

confidence: 99%

Plasma-activation of tap water using DBD for agronomy applications: Identification and quantification of long lifetime chemical species and production/consumption mechanisms

et al. 2018

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Cold atmospheric plasmas are weakly ionized gases that can be generated in ambient air. They produce energetic species (e.g. electrons, metastables) as well as reactive oxygen species, reactive nitrogen species, UV radiations and local electric field. Their interaction with a liquid such as tap water can hence change its chemical composition. The resulting "plasma-activated liquid" can meet many applications, including medicine and agriculture. Consequently, a complete experimental set of analytical techniques dedicated to the characterization of long lifetime chemical species has been implemented to characterize tap water treated using cold atmospheric plasma process and intended to agronomy applications. For that purpose, colorimetry and acid titrations are performed, considering acid-base equilibria, pH and temperature variations induced during plasma activation. 16 species are quantified and monitored: hydroxide and hydronium ions, ammonia and ammonium ions, orthophosphates, carbonate ions, nitrite and nitrate ions and hydrogen peroxide. The related consumption/production mechanisms are discussed. In parallel, a chemical model of electrical conductivity based on Kohlrausch's law has been developed to simulate the electrical conductivity of the plasma-activated tap water (PATW). Comparing its predictions with experimental measurements leads to a narrow fitting, hence supporting the self-sufficiency of the experimental set, I.e. the fact that all long lifetime radicals of interest present in PATW are characterized. Finally, to evaluate the potential of cold atmospheric plasmas for agriculture applications, tap water has been daily plasma-treated to irrigate lentils seeds. Then, seedlings lengths have been measured and compared with untreated tap water, showing an increase as high as 34.0% and 128.4% after 3 days and 6 days of activation respectively. The interaction mechanisms between plasma and tap water are discussed as well as their positive synergy on agronomic results.

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“…Plasmas in-or in-contact with a liquid medium constitute a novel field of research that presents great potential for numerous applications, such as material processing [1]- [3], wastewater treatment [4], agricultural engineering [5]- [7], medical treatment [8]- [10], and others. To date, various plasma sources have been designed, developed, and studied for liquid processing.…”

Section: Introductionmentioning

confidence: 99%

Microwave Plasma Jet in Water: Effect of Water Electrical Conductivity on Plasma Characteristics

Hamdan

Profili

Suk

2019

Plasma Chem Plasma Process

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Plasma-induced water treatment is a novel water treatment technique that has shown high efficiency and flexibility. Although the electrical conductivity of impure water varies depending on the degree of pollution, its influence on plasma treatment efficiency is not well understood. In this study, we investigate the fundamentals of a microwave plasma jet submerged in water with electrical conductivities (σw) ranging from 10 to 10000 µS/cm. The plasma characteristics, namely composition, electron density, and temperature, and their variations as a function of σw, are derived using optical emission spectroscopy. The plasmabubble dynamics is investigated using space-and time-resolved high-speed imaging. The results show that the plasma fills the bubble volume at relatively low flow rate (typically, < 2 L/min) and high σw (typically, > 1000 µS/cm). The influence of σw on the degradation of methylene blue, a standard water pollutant, is also assessed, and the obtained results indicate that the plasma becomes extremely inefficient at high σw. These findings are of great importance for the community of plasma-induced liquid processing, particularly wastewater treatment.

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Formation of ammonium in saline solution treated by nanosecond pulsed cold atmospheric microplasma: a route to fast inactivation of E. coli bacteria

Abstract: † Electronic supplementary information (ESI) available: Methods for ICP-MS, temperature and pH, ion chromatography and colorimetric analyses; OES, pH and ion chromatography data. See

Cited by 30 publications

References 26 publications

Mechanistic insights into the impact of Cold Atmospheric Pressure Plasma on human epithelial cell lines

Mechanistic insights into the impact of Cold Atmospheric Pressure Plasma on human epithelial cell lines

Plasma-activation of tap water using DBD for agronomy applications: Identification and quantification of long lifetime chemical species and production/consumption mechanisms

Microwave Plasma Jet in Water: Effect of Water Electrical Conductivity on Plasma Characteristics

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