“…Three Ad proteins, IVa2, L1-52/55K, and L4-22K, are known to associate with the packaging domain in vitro and/or in vivo, and each is required for viral DNA packaging (5, 7, 9, 16, 19-21, 26, 29-32). The IVa2 protein binds to the CG motif and the L4-22K protein binds the TTTG motif of the packaging A repeats in vitro and in vivo (5,19,26,29). The L1-52/55K protein has only been found to be associated with the packaging domain in vivo, and the L1-52/55K protein associates with IVa2 in vitro (8,19,21).…”