Formation Mechanism and Biomedical Applications of Protease-Manipulated Peptide Assemblies

Jiang, Tianyue; Liu, Chendan; Xu, Xiao; He, Bingfang; Mo, Ran

doi:10.3389/fbioe.2021.598050

Cited by 5 publications

(3 citation statements)

References 53 publications

(58 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meticulous configuration of the factors gives control over the structural transformations and reaction dynamics demonstrated by the nanomaterials . Therefore, it draws immense attention to ponder the interplay of these subatomic interactions to better conceptualize the idea behind peptides and their substrates …”

Section: Peptide As An Alluring Biomaterialsmentioning

confidence: 99%

See 1 more Smart Citation

Self-Assembly of Peptides as an Alluring Approach toward Cancer Treatment and Imaging

Ghafoor,

Song,

Zhou

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Cancer is a severe threat to humans, as it is the second leading cause of death after cardiovascular diseases and still poses the biggest challenge in the world of medicine. Due to its higher mortality rates and resistance, it requires a more focused and productive approach to provide the solution for it. Many therapies promising to deliver favorable results, such as chemotherapy and radiotherapy, have come up with more negatives than positives. Therefore, a new class of medicinal solutions and a more targeted approach is of the essence. This review highlights the alluring properties, configurations, and self-assembly of peptide molecules which benefit the traditional approach toward cancer therapy while sparing the healthy cells in the process. As targeted drug delivery systems, self-assembled peptides offer a wide spectrum of conjugation, biocompatibility, degradability-controlled responsiveness, and biomedical applications, including cancer treatment and cancer imaging.

show abstract

Section: Peptide As An Alluring Biomaterialsmentioning

confidence: 99%

“…54 Therefore, it draws immense attention to ponder the interplay of these subatomic interactions to better conceptualize the idea behind peptides and their substrates. 55 2.3.1. Hydrogen Bonding.…”

Section: Peptide As An Alluring Biomaterialsmentioning

confidence: 99%

Self-Assembly of Peptides as an Alluring Approach toward Cancer Treatment and Imaging

Ghafoor,

Song,

Zhou

et al. 2024

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

show abstract

“…This peptide amphiphile could assemble into nanofibers, which were demonstrated to enter the breast cancer cells, then locate and disrupt the mitochondrial membranes. To increase the targeting efficacy, stimuli such as the endogenous enzyme, redox, and acidic environments, as well as the exogenous light and ultrasound, are employed to guide the targeted selfassemblies (Chen et al, 2018b;Jiang et al, 2021). For instance, Wang et al reported an alkaline phosphatase (ALP)-instructed self-assembling peptide for targeting mitochondria (Wang et al, 2016).…”

Section: Self-assembling Peptidementioning

confidence: 99%

Mitochondria-Targeted Self-Assembly of Peptide-Based Nanomaterials

Luo

Gao

Duan

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Mitochondria are well known to serve as the powerhouse for cells and also the initiator for some vital signaling pathways. A variety of diseases are discovered to be associated with the abnormalities of mitochondria, including cancers. Thus, targeting mitochondria and their metabolisms are recognized to be promising for cancer therapy. In recent years, great efforts have been devoted to developing mitochondria-targeted pharmaceuticals, including small molecular drugs, peptides, proteins, and genes, with several molecular drugs and peptides enrolled in clinical trials. Along with the advances of nanotechnology, self-assembled peptide-nanomaterials that integrate the biomarker-targeting, stimuli-response, self-assembly, and therapeutic effect, have been attracted increasing interest in the fields of biotechnology and nanomedicine. Particularly, in situ mitochondria-targeted self-assembling peptides that can assemble on the surface or inside mitochondria have opened another dimension for the mitochondria-targeted cancer therapy. Here, we highlight the recent progress of mitochondria-targeted peptide-nanomaterials, especially those in situ self-assembly systems in mitochondria, and their applications in cancer treatments.

show abstract