Formation, Identification, and Occurrence of the Furan-Containing β-Carboline Flazin Derived from l-Tryptophan and Carbohydrates
Tomás Herraiz,
Antonio Salgado
Abstract:β-Carbolines (βCs) are bioactive indole alkaloids found in foods and in vivo. This work describes the identification, formation, and occurrence in foods of the βC with a furan moiety flazin (1-[5-(hydroxymethyl)furan-2-yl]-9H-pyrido [3,4-b]indole-3-carboxylic acid). Flazin was formed by the reaction of L-tryptophan with 3-deoxyglucosone but not with 5-hydroxymethylfurfural. Its formation was favored in acidic conditions and heating (70−110 °C). The proposed mechanism of formation occurs through the formation o… Show more
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