A study was carried out to examine formation damage mechanisms caused by drilling fluids in tight reservoirs in several onshore oil fields in Abu Dhabi. Three phases of compatibility corefloods were carried out to identify potential to improve hydrocarbon recovery and examine reformulated/alternate drilling muds and treatment fluids. Interpretation was aided by novel Nano-CT quantifications and visualisations. The first phase examined the current drilling muds and showed inconsistent filtrate loss control alongside high levels of permeability alteration. These alterations were caused by retention of drilling mud constituents in the near-wellbore and incomplete clean-up of drilling mud-cakes. Based upon these results, reformulated and alternate drilling muds were examined in Phase 2, and there was a positive impact upon both filtrate loss and permeability, although the Nano-CT quantifications and visualisations showed that drilling mud constituents were still having an impact upon permeability. Candidate treatment fluids were examined in Phase 3, with all having a positive impact and the best performance coming from 15% HCl and an enzyme-based treatment. The interpretative tools showed that these treatments had removed drilling mud-cakes, created wormholes, and bypassed the areas where constituents were retained. The compatibility corefloods on tight reservoir core, alongside high-resolution quantifications and visualisations, therefore identified damaging mechanisms, helped identify potential to improve hydrocarbon recovery, and identify treatment fluid options which could be used in the fields.