Formation and stability of oil-in-water nanoemulsions containing rice bran oil: in vitro and in vivo assessments

Abstract

BackgroundNanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to create rice bran oil nanoemulsions using low energy emulsification methods and to evaluate their physical stability, irritation potential and moisturising activity on volunteers with normal and diseased skin types.ResultsThe nanoemulsion developed by this phase diagram method was composed of 10% rice bran oil, 10% surfactants sorbitan oleate/PEG-30 castor oil, 0.05% antioxidant and 0.50% preservatives formulated in distilled water. The nanoemulsion was stable over the time course of this study. In vitro assays showed that this formulation has a low irritation potential, and when applied to human skin during in vivo studies, the nanoemulsion improved the skin's moisture and maintained normal skin pH values.ConclusionThe results of irritation potential studies and in vivo assessments indicate that this nanoemulsion has potential to be a useful tool to treat skin diseases, such as atopic dermatitis and psoriasis.

The use of Brazilian vegetable oils in nanoemulsions: an update on preparation and biological applications

“…The nanosized droplets (69 nm) improved the adherence formation of a dense film on the skin which prevents evaporation of the water. This justifies the use of rice bran oil NE developed as an adjuvant for the treatment of psoriasis and atopic dermatitis (Bernardi et al, 2011).…”

“…The nanosized droplets (69 nm) improved the adherence formation of a dense film on the skin which prevents evaporation of the water. This justifies the use of rice bran oil NE developed as an adjuvant for the treatment of psoriasis and atopic dermatitis (Bernardi et al, 2011).Citronella oil (Cymbopogon nardus) has been extensively studied due to its repellent effect against mosquitoes (Trongtokit et al, 2005;Kim et al, 2005;Müller et al, 2008;Yang, Ma, 2005). It is considered effective when used alone at concentrations of 0.05% to 15%, in combination with natural or synthetic repellent compounds (Fradin, Day, 2002).…”

Formulation and Evaluation of Stability of Thai Purple Rice Bran-Based Cosmetic Products

“…Rice bran oil (RBO) is rich in unsaturated fatty acids (oleic, linoleic, and α-linolenic acids) and saturated fatty acids (palmitic and stearic acids). RBOs are used in the cosmetic products, mainly in sunscreen, antiaging, and skin-lightening products, because of its bioactivities and moisturizing properties on the skin [11][12][13][14][15]. Thai-pigmented rice has been reported as an active ingredient in cosmetics, pharmaceuticals, and functional foods [16].…”

Comparative Study of the Lipid Profiles of Oils from Kernels of Peanut, Babassu, Coconut, Castor and Grape by GC-FID and Raman Spectroscopy

“…10,11 In ancient times, the homemade production of castor oil was disseminated by Brazilian countryside families, which had low financial resources and difficulty in the access of health care, for its anti-inflammatory, antioxidant and laxative properties. 12 Several analytical techniques can be applied in analysis and certification of vegetable oils such as liquid chromatography, 13,14 gas chromatography, 15-17 capillary electrophoresis, 18,19 nuclear magnetic resonance, [20][21][22] and near-infrared spectroscopy. 23,24 However, in the last decade vibrational spectroscopies have been presented as an alternative, since the analysis is fast and usually the sample preparation is very simple.…”