Formation and Function of Nano- and Microstructures by the Self-assembly of Cyclic Oligosaccharides ‘Cyclodextrins’

Abstract

Recently, much attention has been paid to studies on nano-and microstructures formed by the self-assembly of cyclodextrins (CDs) in the fields of supramolecular chemistry and material science. CDs can adopt various types of assembly modes in aqueous solution, as well as crystal structures. Channel-type assemblies of γ-CD (γ-CD channel ) formed unique micrometer-sized cubes and rods. By using γ-CD channel as a host, the inclusion of guest molecules dissolved in oils, which has been believed to be impossible, can be realized. Furthermore, γ-CD channel showed excellent oil dispersion, and formed organogels in a variety of oils and organic solvents at ambient temperature. This article reviews the formation behavior and function of nano-and microstructures formed by the self-assembly of CDs. A. IntroductionCyclodextrins (CDs), which are produced from starch by the action of cyclodextrin glucanotransferase, are a class of cyclic oligosaccharides consisting of several α-(1,4)-linked D-glucopyranose units (Fig. 1). CDs composed of 6, 7, and 8 glucosidic units are called α-, β-, and γ-CDs, respectively, and have been used extensively. They have a cavity of sub-

Bitterness-Suppressing Effect of Umami Dipeptides and Their Constituent Amino Acids on Diphenhydramine: Evaluation by Gustatory Sensation and Taste Sensor Testing

“…In addition, the limited size of bitter medicines should be included. 54,55) Cyclodextrins also have been reported to cause gastrointestinal disorders as a side effect. 51) However, as mentioned above, there is a report 56) that cetirizine has been able to suppress bitterness to some extent using cyclodextrin.…”