Formate-Mediated Aryl Halide Reductive Cross-Coupling Catalyzed by Iodide-Bridged Palladium(I) Dimers: Experi-mental and Computational Studies
Yoon Cho,
Yu-Hsiang Chang,
Zachary Strong
et al.
Abstract:The first efficient reductive cross-couplings of aryl halides mediated by an abundant feedstock, sodium formate, are de-scribed. These processes, which exploit air-stable Pd(I) iodide dimers, are especially effective for challenging 2-pyridyl systems due to intervention of chelated intermediates. Furthermore, orthogonality with respect to Suzuki and Buchwald-Hartwig coupling processes is displayed, as pinacol boronates and anilines are tolerated. Although palladium-catalyzed transfer hydrogenolyses of aryl hal… Show more
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