Formate assay in body fluids: Application in methanol poisoning

“…In addition, glioma subtypes can be identified by the IDH1/IDH2 mutation [11, 27]. The second most important genetic alteration is a co-deletion at chromosome regions 1p and 19q, which results from a chromosomal translocation t(1p;19q)(q10;p10), and is exclusively associated with ODGs and better prognosis [20]. Such examples demonstrate that the identification of new molecular genetic changes, which occur during glioma formation or development, are necessary to better guide clinical decision making.…”

Section: Introductionmentioning

confidence: 99%

The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas

Lee

Koh

Kim

et al. 2017

acta neuropathol commun

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Mutations in the telomerase reverse transcriptase gene promoter (TERTp) are common in glioblastomas (GBMs) and oligodendrogliomas (ODGs), and therefore, have a key role in tumorigenesis and may be of prognostic value. However, the extent of their prognostic importance in various gliomas is controversial. We studied 168 patients separated into five groups: Group 1: 65 patients with ODG carrying an IDH1 or IDH2 mutation (IDH-mutant) and 1p/19q–codeletion, Group 2: 23 patients with anaplastic astrocytoma (AA), IDH-mutant, Group 3: 13 patients with GBM, IDH-mutant, Group 4: 15 patients with AA, IDH-wildtype (WT), and Group 5: 52 patients with GBM, IDH-WT. TERTp mutations were found in 96.9%, 4.4%, 76.9%, 20.0%, and 84.6% of patients in Groups 1, 2, 3, 4, and 5, respectively. The R132H mutation in IDH1 was found in 60.5% (23/38) of patients in the AA cohort (Groups 2 and 4) and 20.0% (13/65) of patients from our GBM cohort (Groups 3 and 5), whereas all patients with ODG (Group 1) had a mutation either in IDH1 (n = 62) or IDH2 (n = 3). Using Kaplan Meier survival analysis, we found that the TERTp mutation was correlated with poor overall survival (OS) in Groups 2 and 4 combined (P = 0.001) and in Group 4 (P = 0.113), and in multivariate analysis, the TERTp mutant group was associated with significantly poor survival in Group 5 (P = 0.045). However, IDH mutation, MGMT methylation, and younger patient age (<55 years old) were significantly correlated with favorable OS (all P < 0.05) in our cohort of astrocytic and ODGs. In patients with ODG (Group 1), mutant IDH and TERTp did not have prognostic value because these mutations were universally present. Based on the revised 2016 WHO classification of gliomas, we found that TERTp mutation was frequently present in patients with GBM or ODG and because it was strongly correlated with poor survival outcome in patients with IDH-WT GBM in multivariate analysis, it may be of prognostic value in this subgroup of patients with gliomas.

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“…The title compound exhibit antiviral activities [7], while the isopropyl derivatives of tropolone (β-thujaplicin and γ-thujaplicin) were reported to have antifungal and antibacterial properties [6]. Thus these derivatives are used in the preservation of wood [8,9]. The title compound consists of a tropolone core with three methyl morpholine moieties bound to it at C3, C5 and C7 of the backbone, with additional water (0.67 occupancy) completing the asymmetric unit, as shown in the gure.…”

Section: Discussionmentioning

confidence: 99%

Crystal structure of 3,5,7-tris(morpholinomethyl)tropolone·0.67 hydrate, C₂₂H₃₃N₃O₅·0.67H₂O

Schutte‐Smith

Bungu

Steyl

et al. 2016

Zeitschrift Für Kristallographie - New Crystal Structures

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Formate assay in body fluids: Application in methanol poisoning

Cited by 178 publications

References 9 publications

Photocatalytic Degradation of Toxic Methyl Red Dye Using Silica Nanoparticles Synthesized from Rice Husk Ash

Photocatalytic Degradation of Toxic Methyl Red Dye Using Silica Nanoparticles Synthesized from Rice Husk Ash

The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas

Crystal structure of 3,5,7-tris(morpholinomethyl)tropolone·0.67 hydrate, C₂₂H₃₃N₃O₅·0.67H₂O

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Formate assay in body fluids: Application in methanol poisoning

Cited by 178 publications

References 9 publications

Photocatalytic Degradation of Toxic Methyl Red Dye Using Silica Nanoparticles Synthesized from Rice Husk Ash

Photocatalytic Degradation of Toxic Methyl Red Dye Using Silica Nanoparticles Synthesized from Rice Husk Ash

The frequency and prognostic effect of TERT promoter mutation in diffuse gliomas

Crystal structure of 3,5,7-tris(morpholinomethyl)tropolone·0.67 hydrate, C22H33N3O5·0.67H2O

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Crystal structure of 3,5,7-tris(morpholinomethyl)tropolone·0.67 hydrate, C₂₂H₃₃N₃O₅·0.67H₂O