Formant Frequencies, Cephalometric Measures, and Pharyngeal Airway Width in Adults With Congenital, Isolated, and Untreated Growth Hormone Deficiency

Reinheimer, Daniele Machado; Andrade, Bruna Mateus Rocha de; Nascimento, Jéssica K.F.; Fonte, Juliana Batista Melo Da; Araujo, Isabella Maria Porto de; Martins-Filho, Paulo Ricardo; Salvatori, Roberto; Valença, Eugênia H O; Oliveira, Alaíde H.A.; Aguiar‐Oliveira, Manuel H.; Oliveira-Neto, Luiz A.

doi:10.1016/j.jvoice.2019.04.014

Cited by 8 publications

(2 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data in Table 1 show an uneven reduction in bone, as expressed in standard deviation scores (SDSs) and nonbone measures, corrected by body surface. It adds very recent data about the dental arches (29) and the mesiodistal measurement of the teeth (30) to several previously published papers (31)(32)(33)(34)(35)(36)(37)(38)(39)(40). The pattern of cephalometric measures explains the doll facies and their high-pitched voice.…”

Section: Sergipe In Gh Researchmentioning

confidence: 76%

The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

Aguiar‐Oliveira¹,

Salvatori²

2022

Archives of Endocrinology and Metabolism

Self Cite

View full text Add to dashboard Cite

In the late 19 th century, José Dantas de Souza Leite, a physician born in Sergipe, published the first detailed clinical description of acromegaly under the guidance of the French neurologist Pierre Marie. In 2014, the Brazilian Society of Endocrinology and Metabolism created the "José Dantas de Souza Leite Award" , which is granted every two years to a Brazilian researcher who has contributed to the development of endocrinology. In 2022, the award was given to another physician from Sergipe, Manuel Hermínio de Aguiar Oliveira, from the Federal University of Sergipe for the description of "Itabaianinha syndrome" in a cohort of individuals with isolated GH deficiency due to a homozygous inactivating mutation in the GH-releasing hormone receptor gene. This research, which was carried out over almost 30 years, was performed in partnership with Roberto Salvatori from Johns Hopkins University and in collaboration with other researchers around the world. This review article tells the story of Souza Leite, some milestones in the history of GH, and summarizes the description of Itabaianinha syndrome.

show abstract

Section: Sergipe In Gh Researchmentioning

confidence: 76%

The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

Aguiar‐Oliveira¹,

Salvatori²

2022

Archives of Endocrinology and Metabolism

Self Cite

View full text Add to dashboard Cite

show abstract

“…Interestingly, these individuals seem to cope better with their short stature than with their voice, since they rate their overall quality of life as excellent (15) but rate their V-RQOL as low (13). To examine this dissociation, until now, we had focused on physical aspects, such as reduced head circumference (13) and facial depth, cephalometric changes, and reduction of most hard (16) and soft structures of the vocal tract, except the pharyngeal airway width (17). However, the impacts of these changes on the social aspects of the voice are not presently known.…”

Section: Introductionmentioning

confidence: 99%

Art and science: impact of semioccluded vocal tract exercises and choral singing on quality of life in subjects with congenital GH deficiency

Andrade¹,

Valença²,

Salvatori³

et al. 2022

Archives of Endocrinology and Metabolism

Self Cite

View full text Add to dashboard Cite

Objectives: Currently, not much is known about the interactions between voice and growth hormone (GH). We have described large kindred with isolated GH deficiency (IGHD) due to a GHRH receptor mutation, resulting in severe short stature and high-pitched voice. These IGHD individuals have little interest in GH treatment, as they consider themselves "short long-lived people" , rather than patients. Interestingly, they report normal general quality of life, but they rate their Voice-Related Quality of Life (V-RQOL) as low. Here, we assessed the social and auditory-perceptual impacts of artisticintervention voice therapy with semioccluded vocal tract exercises (SOVTE) and choral singing, on their voices. Material and methods: Seventeen GH-naïve adult IGHD individuals were enrolled in a single-arm interventional pre-post study with 13 weekly sessions of choir singing over 90 days. Outcome measures were V-RQOL scores, self-assessment of voice, and auditory-perceptual analysis (GRBAS scale, G: grade of the severity of dysphonia; R: roughness; B: breathiness; A: asthenia; and S: strain). Results: Marked improvements in total (p = 0.0001), physical (p = 0.0002), and socioemotional (p = 0.0001) V-RQOL scores and in self-assessment of voice (p = 0.004) were found. The general grades of vocal deviation (p = 0.0001), roughness (p = 0.0001), breathiness (p = 0.0001) and strain (p = 0.0001) exhibited accentuated reductions. Conclusions: Voice therapy with semioccluded vocal tract exercises and choral training improved social impact and perceptual voice assessments in IGHD subjects and markedly improved their voice-related quality of life. This is particularly important in a setting where GH replacement therapy is not widely accepted.

show abstract

Disruption of the GHRH receptor and its impact on children and adults: The Itabaianinha syndrome

Aguiar‐Oliveira

Salvatori

2020

Rev Endocr Metab Disord

View full text Add to dashboard Cite

Formant Frequencies, Cephalometric Measures, and Pharyngeal Airway Width in Adults With Congenital, Isolated, and Untreated Growth Hormone Deficiency

Cited by 8 publications

References 30 publications

The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

The state of Sergipe contribution to GH research: from Souza Leite to Itabaianinha syndrome

Art and science: impact of semioccluded vocal tract exercises and choral singing on quality of life in subjects with congenital GH deficiency

Disruption of the GHRH receptor and its impact on children and adults: The Itabaianinha syndrome

Contact Info

Product

Resources

About