Formamidinesulfinic Acid‐Functionalized Fe₃O₄@SiO₂ as a Green and Magnetic Recyclable Catalyst for Synthesis of Pyrano[2, 3‐d] pyrimidinone Derivatives

Abstract

Formamidine sulfonic acid (FSA) stabilized on silica-coated Fe 3 O 4 magnetic nanoparticles as an efficient and hydrogen bonding catalyst was employed for Knoevenagel condensation and synthesis of pyrano [2, 3-d]pyrimidinone derivatives by the one-pot three-component condensation reaction in water at room temperature. The catalyst can be separated from the mixture reaction which is in close agreement with green chemistry disciplines.

Furo, Pyrano, and Pyrido[2,3‐d]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications

“…Using silica‐coated Fe 3 O 4 magnetic nanoparticles to stabilize Formamidine sulfonic acid (FSA), Ghandi and his colleagues [60] devised a catalyst for Knoevenagel condensation and the synthesis of pyrano[2, 3‐ d ] pyrimidinone 18 derivatives. The reaction was carried out in water at room temperature using a one‐pot three‐component condensation reaction.…”

Butane‐1‐sulfonic acid immobilized on magnetic Fe3O4@SiO2 nanoparticles: A novel and heterogeneous catalyst for the one‐pot synthesis of barbituric acid and pyrano[2,3‐d] pyrimidine derivatives in aqueous media

“…In recent years the use of magnetic nanoparticles (MNPs) for the preparation of supported heterogeneous catalysts has attracted significant attention . This attention can be attributed to the unique properties of these types of compounds including high thermal and mechanical stability, large surface area to volume ratio, low toxicity, ease of recovery by use of an external magnetic field and well‐defined pore size distribution .…”