Formaldehyde in Hypoallergenic Household Gloves

Liou, Yujie Linda; Schlarbaum, Jamie P.; Kimyon, Rebecca S.; Hylwa, Sara

doi:10.1097/der.0000000000000426

Cited by 6 publications

(3 citation statements)

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“…FA‐containing household detergents, including all‐purpose cleaners and dishwashing liquids, but also industrially used cleaning agents, and even reusable gloves, 54 even if the latter are labeled as “hypoallergenic,” 55 may all be relevant sources of (occupational) hand dermatitis. Peculiar cases of hand dermatitis due to the presence of FA in cigarettes have occasionally been published 56 ; it is noteworthy that FA can also be present in electronic cigarettes 57 .…”

Section: Clinical Picturementioning

confidence: 99%

Contact allergy to and allergic contact dermatitis from formaldehyde and formaldehyde releasers: A clinical review and update

Goossens

Aerts

2022

Contact Dermatitis

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This review aims to provide a clinically useful update regarding the role of formaldehyde (FA) and its five main releasers (FRs) quaternium‐15, diazolidinyl urea, DMDM hydantoin, imidazolidinyl urea, and 2‐bromo‐2‐nitropropane‐1,3‐diol (bronopol) in contact allergy and allergic contact dermatitis. These ubiquitous preservatives are still often present, and sometimes undeclared, in cosmetics, pharmaceuticals, medical devices, household detergents, and chemical (industrial) products. In Europe, the use of free FA and quaternium‐15 in cosmetics is forbidden and contact allergy rates have been found to be stable to decreasing. However, FA/FRs still readily provoke localized (eg, facial/hand), airborne, and generalized dermatitis, and may also complicate atopic and stasis dermatitis, or result in nummular dermatitis. Seborrheic‐, rosacea‐ and impetigo‐like dermatitis have recently been reported. For a correct diagnosis, FA 2% aq. (0.60 mg/cm2) should be used, and particularly the FRs bronopol 0.5% pet. and diazolidinyl urea 2% pet. should be patch tested separately in a baseline series. If sensitization to FA occurs, both FA and FRs should preferably be avoided, except perhaps for bronopol in case it tests negatively. If a patient reacts to one or more FRs (such as bronopol or diazolidinyl/imidazolidinyl urea), but not to FA, then the specific FR(s) should be avoided.

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Section: Clinical Picturementioning

confidence: 99%

Contact allergy to and allergic contact dermatitis from formaldehyde and formaldehyde releasers: A clinical review and update

Goossens

Aerts

2022

Contact Dermatitis

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“…Die meisten Patienten haben Kontakt mit mehr als einem Produkt, das Formaldehydabspalter enthält, und obwohl die Kontaktallergie gegen jeden davon bei konsekutiven Patienten unter 1 % lag [137], ergibt sich in der Summe eine erhebliche Krankheitslast. Eine weitere unerwartete Formaldehydquelle, die bei einem sensibilisierten Patienten zu einer ACD der Hände führte, wurde in den USA beschrieben, wo mit der Chromotropsäure-Methode festgestellt wurde, dass Handschuhe der Marke Mr. Clean Bliss TM Formaldehyd abgeben [138]. In einer Stichprobe von 28 US-Nagellacken, die als „formaldehydfrei“ beworben wurden, wurde in 4 Produkten dennoch Formaldehyd nachgewiesen [139].…”

Section: Ergebnisseunclassified

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

Uter¹,

Werfel

Lepoittevin

et al. 2021

Kompass Dermatol

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Kontaktallergie (Sensibilisierung) und daraus resultierende allergische Kontaktdermatitis (ACD) sind von erheblicher Tragweite aus Sicht des Gesundheitswesens. Für die vorliegende Übersichtsarbeit hierzu wurden alle passenden Artikel aus dem Zeitraum 2018–2019 per systematischer Suche in Medline und Web of Science<sup>TM</sup> ermittelt; außerdem wurden alle verfügbaren Ausgaben der Fachzeitschriften „Contact Dermatitis“ und „Dermatitis“ manuell durchsucht und so eine frühere, ähnliche Übersichtsarbeit fortgeschrieben und neu fokussiert. Neue Allergene ebenso wie bekannte Allergene, die in neuem Expositionskontext gefunden wurden oder deren Bedeutung in sonstiger Hinsicht neu bewertet wurde, werden in Abschnitten nach Substanzklasse gegliedert beschrieben (z. B. Metalle, Konservierungsmittel, Duftstoffe). Als gemeinsames Ergebnis zahlreicher Untersuchungen fällt sowohl ein Mangel an Informationen über die Produktzusammensetzung auf, z. B. in Bezug auf ein neu beschriebenes Allergen in Leinenturnschuhen (Dimethylthiocarbamylbenzothiazolsulfid), als auch vor allem die mangelnde Kooperativität von Herstellern von Blutzuckermessgeräten bzw. Insulinpumpen. Zu den letztgenannten Geräten hat eine internationale Zusammenarbeit zwischen Dermatologen und Chemikern gezeigt, dass sie bei zahlreichen Diabetikern schwere ACD verursachen, indem sie Isobornylacrylat bzw. N,N’-Dimethylacrylamid freisetzen. Eine verbesserte und vollständige Deklaration der Inhaltsstoffe für Produkte alle Art – und nicht nur, wie wir es derzeit in Europa haben, bei Kosmetika (abgesehen von der vollständigen Auflistung der Duftstoffe) – muss auf die legislative Agenda gesetzt werden.

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“…Most patients are exposed to more than one product containing formaldehyde releasers, and although contact allergy to each of these is below 1% in consecutive patients [137], this adds up to a considerable burden of morbidity. An unexpected source of formaldehyde, eliciting ACD of the hands in a sensitised subject, has been described from the USA, where Mr. Clean Bliss™ gloves were found to release formaldehyde using the chromotropic acid method [138]. Among a sample of 28 US nail polishes advertised to be "formaldehyde-free", four were found to actually contain formaldehyde [139].…”

Section: Preservativesmentioning

confidence: 99%

Contact Allergy—Emerging Allergens and Public Health Impact

Uter

Werfel

Lepoittevin

et al. 2020

IJERPH

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Contact allergy (sensitisation) and allergic contact dermatitis (ACD) resulting from it have a considerable public health impact. For the present review, all pertinent articles were systematically searched via Medline and Web of Science™; additionally, all available issues of the journals “Contact Dermatitis” and “Dermatitis” were manually searched, covering the years 2018–2019, thereby extending and re-focusing a previous similar review. New allergens, or previously described allergens found in a new exposure context or of other current importance, are described in sections according to substance classes, e.g., metals, preservatives, fragrances. As a common finding in many investigations, a lack of information on product composition has been noted, for instance, regarding a newly described allergen in canvas shoes (dimethylthiocarbamylbenzothiazole sulfide) and, most notably, absence of co-operation from manufacturers of glucose-monitoring devices and insulin pumps, respectively. These latter devices have been shown to cause severe ACD in a considerable number of diabetic patients caused by the liberation of isobornyl acrylate and N,N’-dimethylacrylamide, respectively, as demonstrated by an international collaboration between dermatologists and chemists. Improved and complete ingredient labelling for all types of products, and not just as we have with cosmetics at present (apart from full listing of fragrance substances) in Europe, must be put on the legislative agenda.

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Formaldehyde in Hypoallergenic Household Gloves

Cited by 6 publications

References 1 publication

Contact allergy to and allergic contact dermatitis from formaldehyde and formaldehyde releasers: A clinical review and update

Contact allergy to and allergic contact dermatitis from formaldehyde and formaldehyde releasers: A clinical review and update

Kontaktallergien – Neu aufkommende Allergene und Auswirkungen für das Gesundheitswesen

Contact Allergy—Emerging Allergens and Public Health Impact

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