Formaldehyde, Hematotoxicity, and Chromosomal Changes—Response

Rothman, Nathaniel; Zhang, Luoping; Smith, Martyn T.; Vermeulen, Roel; Lan, Qing

doi:10.1158/1055-9965.epi-17-0804

Cited by 4 publications

(2 citation statements)

References 13 publications

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“…The researchers described an augmented occurrence of monosomy 7 and trisomy 8 in metaphase spreads obtained from cultures of CFU-GM colony cells [11]. According to their data, Zhang et al settled that FA exposure can cause unfavorable action on the hematopoietic system, and that leukemia initiation by FA is biologically possible, although authors discussed the limitations of their research and the need for replication and extension of the study [12].…”

Section: Resultsmentioning

confidence: 99%

Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature

et al. 2019

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Background and objective: The aim of the present study was to evaluate associations between cumulative and peak formaldehyde exposure and occurrence of acute myeloid leukemia. Material and Methods: A comprehensive search was performed using the PubMed and Embase databases. We included studies presenting information about the role of formaldehyde in leukemic occurrence and mortality risk. Then, full texts of the selected references were assessed, and references of included studies were checked to identify additional articles. Result: The information was then summarized and organized in the present review. A total of 81 articles were obtained from the search. Conclusion: Findings from the review of the literature do not support the hypothesis that formaldehyde is a cause of acute myeloid leukemia.

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Section: Resultsmentioning

confidence: 99%

Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature

et al. 2019

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“…Formaldehyde reduces the expression of GM-CSFRα and EPOR genes, interfering with the activity of hematopoietic growth factors [ 61 ]. One study showed that exposure to formaldehyde increases the risk of chromosomal aberrations occurring in the course of AML (chromosome 7 monosomy and chromosome 8 trisomy); however, the methodology of the study is now questioned and the need to repeat it is indicated [ 62 , 63 , 64 , 65 , 66 ]. The IARC classified formaldehyde as a human carcinogen (group 1), capable of inducing nasopharyngeal cancer (2004) and leukemia (2012), especially AML [ 8 , 39 , 45 , 47 , 58 ].…”

Section: Electrochemical Sensors For the Detection Of Chemical Carcin...mentioning

confidence: 99%

Electrochemical and Optical Sensors for the Detection of Chemical Carcinogens Causing Leukemia

Kowalczyk

Zarychta

Lejman

et al. 2023

Sensors

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The incidence and mortality due to neoplastic diseases have shown an increasing tendency over the years. Based on GLOBOCAN 2020 published by the International Agency for Research on Cancer (IARC), leukemias are the thirteenth most commonly diagnosed cancer in the world, with 78.6% of leukemia cases diagnosed in countries with a very high or high Human Development Index (HDI). Carcinogenesis is a complex process initiated by a mutation in DNA that may be caused by chemical carcinogens present in polluted environments and human diet. The IARC has identified 122 human carcinogens, e.g., benzene, formaldehyde, pentachlorophenol, and 93 probable human carcinogens, e.g., styrene, diazinone. The aim of the following review is to present the chemical carcinogens involved or likely to be involved in the pathogenesis of leukemia and to summarize the latest reports on the possibility of detecting these compounds in the environment or food with the use of electrochemical sensors.

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Formaldehyde and Other Saturated Aldehydes

Leikauf¹

2020

Environmental Toxicants

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Formaldehyde, Hematotoxicity, and Chromosomal Changes—Response

Cited by 4 publications

References 13 publications

Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature

Formaldehyde Exposure and Acute Myeloid Leukemia: A Review of the Literature

Electrochemical and Optical Sensors for the Detection of Chemical Carcinogens Causing Leukemia

Formaldehyde and Other Saturated Aldehydes

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