Formaldehyde derived from dietary aspartame binds to tissue components in vivo

Trocho, Carme; Pardo, Rosario; Rafecas, I.; Virgili, J.; Remesar, Xavier; Fernández-López, José Antonio; Alemany, M.

doi:10.1016/s0024-3205(98)00282-3

Cited by 126 publications

(94 citation statements)

References 30 publications

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“…A soft drink containing 32.6 g of fructose could increase the fasting serum fructose fourfold. A 340 g soft drink sweetened with fructose-55 contains approximately 40 g of the sweetener (ie, 22 g of fructose and 17 g of glucose, representing a fructose excess of 5 g per can) (20,29). Fructose affects each of the three major factors that are believed to contribute to the pathogenesis of diabetic end organ damage.…”

Section: Discussionmentioning

confidence: 99%

“…Aspartame is absorbed from the intestine and metabolized by the liver to form phenylalanine, aspartic acid and methanol. This process causes mitochondrial dysfunction and ATP depletion, which contribute to accumulation of fat (29). Also, regarding obesity and aspartame, formaldehyde converted from the free methyl alcohol accumulates in the cells and damages mitochondrial DNA, with most toxicity effects occurring in the liver.…”

Section: Discussionmentioning

confidence: 99%

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Soft Drink Consumption Linked with Fatty Liver in the Absence of Traditional Risk Factors

Assy

Nasser

Kamayse

et al. 2008

Canadian Journal of Gastroenterology

289

194

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BACKGROUND: Little is known about dietary habits and their relationships with liver disease in nonalcoholic fatty liver disease (NAFLD) patients, particularly in the absence of obesity, diabetes or hyperlipidemia. OBJECTIVE: To assess the association between soft drink consumption and the presence of fatty liver in NAFLD patients who do not have classic risk factors. METHODS: Three hundred ten patients with NAFLD diagnosed by ultrasound were assessed for 36 months in a cross-sectional manner. Thirty-one patients (10%) who had NAFLD without classic risk factors were compared with 30 healthy controls. Physical activity was assessed during the preceding week and year, and every six months for 36 months. Data on daily dietary intake of food and soft drink, and the source of added sugar were collected during two seven-day periods, at the beginning of the study, and within two weeks after the metabolic tests by using a validated food questionnaire given by a trained dietician. Insulin resistance and lipid peroxidation were assessed by homeostasis model assessment-insulin resistance index (HOMA-IRI) and malondialdehyde (MDA) levels, respectively. RESULTS: Eighty per cent of patients (25 of 31) consumed an excessive amount of soft drink beverages (more than 50 g/day of added sugar) for 36 months, compared with 20% in healthy controls (P<0.001). Twenty per cent of patients consumed one drink per day, 40% consumed two to three drinks per day, and 40% consumed more than four drinks per day for most days during 36 months. The most common soft drinks consumed were regular Coca-Cola (40% of patients), Diet Coke (40%) and flavoured fruit juices (20%). Ultrasound findings revealed mild fatty liver in 44% of cases (n=14), moderate fatty liver in 38% (n=12), and severe fatty liver in 18% (n=5). HOMA-IRI and MDA levels were significantly higher in patients with NAFLD than in healthy controls (HOMA-IRI, 3.7 versus 1.7, P<0.001; and MDA, 420±300 μmol/mL versus 200±100 μmol/mL; P<0.001). When controlled for other factors, including dietary composition and physical activity, soft drink beverage consumption was the only independent variable that was able to predict the presence of fatty liver in 82.5% of cases with a sensitivity of 100%, a specificity of 76%, a positive predictive value of 57% and a negative predictive value of 100%. CONCLUSION: The present study may add important insight into the role of sugar-sweetened beverage consumption as a cause of fatty liver in patients without risk factors. Patients are encouraged to change their long-standing drinking behaviour.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Soft Drink Consumption Linked with Fatty Liver in the Absence of Traditional Risk Factors

Assy

Nasser

Kamayse

et al. 2008

Canadian Journal of Gastroenterology

289

194

View full text Add to dashboard Cite

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“…Effects of aspartame on the brain P Humphries et al than methanol is itself considered to cause methanol toxicity (Stegink et al, 1989), but research has shown that formaldehyde adducts accumulate in the tissues, in both proteins and nucleic acids, after aspartame ingestion (Trocho et al, 1998). The formed adducts of the metabolic poisons alter both mitochondrial DNA and nucleic DNA.…”

Section: Succinic Semialdehydementioning

confidence: 99%

Direct and indirect cellular effects of aspartame on the brain

2007

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“…Once ingested during metabolism, aspartame breaks down in intestinal lumen. Apart from it's constituent amino acids aspartic acid and phenylalanine and methanol it further breakdown to form formaldehyde, formic acid, diketopiperazine, which further metabolized in vivo [14,15]. Production of essential amino acid phenylalanine is a health hazard to those born with phenylketonuria (PKU) a rare inherited disease.…”

Section: Biochemistry Of Aspartamementioning

confidence: 99%

Untitled

2017

MOJT

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Aspartame is very popular artificial sweetener with very low calorific value. Since last few decades use of aspartame has been drastically enhanced among the population worldwide. Not only the diabetic persons but also diet conscious young and teen-agers are also consuming aspartame without any concern or much knowledge. Consumers are using the aspartame irrespective of their clinical conditions and age. Sugar free diet products are very much popular among children and teenagers. It has been also noticed that, aspartame issued under commercial trade without any warning or specific intake limit on label. Presently aspartame consumed widely by the population via cold drinks, diet soda, low calorie sweet products, sugar free sweet products and medications. Although, many research studies indicate clearly about the associated side effects of aspartame consumption. So, in the light of available scientific research, the use of this synthetic sweetener is questionable and controversial. Purpose of this review is to spread the awareness about the possible adverse after effects of unconscious aspartame consumption. Present review is an interactive and comprehensive presentation of facts and information related to aspartame for the awareness of researchers and mass population.

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Formaldehyde derived from dietary aspartame binds to tissue components in vivo

Cited by 126 publications

References 30 publications

Soft Drink Consumption Linked with Fatty Liver in the Absence of Traditional Risk Factors

Soft Drink Consumption Linked with Fatty Liver in the Absence of Traditional Risk Factors

Direct and indirect cellular effects of aspartame on the brain

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