Formaldehyde and tripolyphosphate crosslinked chitosan hydrogels: Synthesis, characterization and modeling

Castillo, Nahúm Andrés Medellín; Isaacs-Páez, Elizabeth Diane; Rodríguez-Méndez, Itzia; González‐García, Raúl; Labrada-Delgado, Gladis Judith; Aragón‐Piña, Antonio; García-Arreola, María Elena

doi:10.1016/j.ijbiomac.2021.06.020

Cited by 31 publications

(10 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Resultsmentioning

confidence: 99%

“…[45] According to the literature, the CS crosslinking with TPP is obtained by the reaction between the positive amino groups in CS side chains and the negatively charged phosphate groups of TPP. [52] It was widely reported that the nature and concentration of crosslinkers, used for the improvement of the interconnection between the polysaccharide chains, [53] greatly affected the properties of the final materials, with the balance between stiffness and softness being the driving force of the performance of devices designed for healing applications. [54] The strength of the hydrogel increases with increased amount of TPP, but the crosslinking reduces the number of amino and hydroxyl groups in chitosan backbone, thus negatively affecting both the swelling properties and the interactions with bioactive molecules.…”

Section: Synthesis and Physico-chemical Characterization Of Hybrid Hy...mentioning

confidence: 99%

See 1 more Smart Citation

Evaluating the Efficiency of Chitosan‐Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems

Luca

Poursani

Curcio

et al. 2023

Macro Materials & Eng

View full text Add to dashboard Cite

With the objective of creating an electro‐responsive and antimicrobial device suitable as delivery system for Rose Bengal (RB) to the skin, a hybrid hydrogel combining Chitosan (CS) and Graphene Oxide (GO) are designed, serving as functional polymer support and active filling element, respectively. The hybrid system, synthesized using tripolyphosphate as a crosslinker via ionic gelation, shows a uniform and homogeneous surface, as verified by SEM investigations, high biocompatibility when tested on human fibroblast lung cells MRC‐5 cells, and biodegradability in phosphate buffered medium at physiological pH. Drug loading and release experiments, extensively analyzed using suitable mathematical modeling, shows the enhancement of the binding efficiency conferred by GO (534 and 979 mg g−1 for blank and hybrid hydrogels, respectively) and an electro‐responsive behavior (maximum BR release of 36 and 23% at 0 and 12 V, respectively). Additionally, hybrid hydrogel is found to prevent the adhesion of methicillin‐resistant Staphylococcus aureus and to kill the bacterial cells by taking advantage of the sustained release of the antimicrobial RB.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Synthesis and Physico-chemical Characterization Of Hybrid Hy...mentioning

confidence: 99%

Evaluating the Efficiency of Chitosan‐Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems

Luca

Poursani

Curcio

et al. 2023

Macro Materials & Eng

View full text Add to dashboard Cite

show abstract

“…However, topical drugs have the characteristics of high speci city, small side effects, and patient compliance; therefore, they are generally preferred in clinical treatment [32,33]. Gel drugs are often selected based on gel materials with good biocompatibility and certain loading effects (such as chitosan gel [34] and hyaluronic acid gel [35]) , on which related drugs are loaded, such as antibiotics[36]and anti-tumor drugs [37]. However, after reviewing these investigations, we discovered that there are many problems in the drug matrix, loading concentration, and loading type of current clinical gel drugs.…”

Section: Discussionmentioning

confidence: 99%

Adjunctive Drug-Loaded Gel Application in the Treatment of Periodontitis: A Systematic Evaluation and Meta-Analysis

Yang

Wang

et al. 2022

Preprint

View full text Add to dashboard Cite

Background This meta-analysis aimed to assess and systematically investigate the efficacy of drug-loaded gel adjuncts in the treatment of periodontitis based on relevant literature. Methods Six databases including the China National Knowledge Infrastructure, WanFang Data, VIP Chinese Science and Technology Periodical Database, China Biology Medicine disc, Cochrane library, PubMed, and Web of Science were searched from the establishment of the database until December 2021 for randomized controlled trials (RCTs) that studied the application of drug-loaded gel in periodontitis treatment. The meta-analysis was conducted using Stata 15.0 and Review Manager 5.4 for articles that met the criteria. Results The study included nine RCTs involving 706 participants. Periodontal probing depth (PPD) and clinical attachment level (CAL) were the primary and secondary outcomes, respectively. The subgroup analyses performed for PPD (standardized mean difference [SMD] = 0.59, 95% confidence interval [CI]=[0.44, 0.73], I2 = 48.0%, p = 0.05) and CAL (SMD = 0.58, 95% CI=[0.34, 0.82], I2 = 61.0%, p = 0.005) of follow-up period revealed that the heterogeneity (p) among groups of each indicator is 0.98 and 0.96, respectively. The gel component was analyzed as another subgroup factor, reflected by heterogeneity (p = 0.23) among groups and Egger test (p = 0.794) in PPD, while the results of those in CAL were 0.1 and 0.079, respectively. Conclusion The application of drug-loaded gel as an adjunctive therapy for periodontitis resulted in effectively reduced PPD and promoted CAL recovery, providing an evidence-based improvement in efficacy, security, and rational use for clinical drug therapy instruction for periodontitis.

show abstract

“…These bonds create a tighter polymer network. The most common organic compounds used for the chemical gelation of chitosan include glutaraldehyde [ 99 ], formaldehyde [ 100 ], epichlorohydrin [ 101 ], genipin [ 102 ], and glyoxal [ 103 ].…”

Section: Sol-gel Methodsmentioning

confidence: 99%

Neat Chitosan Porous Materials: A Review of Preparation, Structure Characterization and Application

Grzybek

Jakubski

Dudek

2022

IJMS

View full text Add to dashboard Cite

This review presents an overview of methods for preparing chitosan-derived porous materials and discusses their potential applications. This family of materials has garnered significant attention owing to their biocompatibility, nontoxicity, antibacterial properties, and biodegradability, which make them advantageous in a wide range of applications. Although individual porous chitosan-based materials have been widely discussed in the literature, a summary of all available methods for preparing materials based on pure chitosan, along with their structural characterization and potential applications, has not yet been presented. This review discusses five strategies for fabricating porous chitosan materials, i.e., cryogelation, freeze-drying, sol-gel, phase inversion, and extraction of a porogen agent. Each approach is described in detail with examples related to the preparation of chitosan materials. The influence of the fabrication method on the structure of the obtained material is also highlighted herein. Finally, we discuss the potential applications of the considered materials.

show abstract

Formaldehyde and tripolyphosphate crosslinked chitosan hydrogels: Synthesis, characterization and modeling

Cited by 31 publications

References 28 publications

Evaluating the Efficiency of Chitosan‐Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems

Evaluating the Efficiency of Chitosan‐Graphene Oxide Hybrid Hydrogels as Drug Delivery Systems

Adjunctive Drug-Loaded Gel Application in the Treatment of Periodontitis: A Systematic Evaluation and Meta-Analysis

Neat Chitosan Porous Materials: A Review of Preparation, Structure Characterization and Application

Contact Info

Product

Resources

About