Formaldehyde and chemosensory irritation in humans: A controlled human exposure study

Lang, Isabelle; Brückner, Thomas; Triebig, Gerhard

doi:10.1016/j.yrtph.2007.08.012

Cited by 135 publications

(76 citation statements)

References 51 publications

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“…This observation is in agreement with many other studies revealing that exposure of medical students to FA provoked eye irritation and resulted in itching, burning, soreness, pain, or conjunctivitis [4,9,13]. For example, Lang et al found that FA increased nasal problems similar to that experienced by our students (dryness, bleeding) [25]. Akbar-Khanzadeh and Mlynek found a predominance of the eye irritation (in 82% of students) and nose problems (in 76% of students) [26].…”

Section: Discussionsupporting

confidence: 93%

“…Akbar-Khanzadeh and Mlynek found a predominance of the eye irritation (in 82% of students) and nose problems (in 76% of students) [26]. Usually eye and nasal irritation did not occur in parallel because the eyes are more sensitive; moreover, the experienced symptoms to some extent depended on individual sensitivity to chemicals/toxicants [25].…”

Section: Discussionmentioning

confidence: 99%

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Formaldehyde-related clinical symptoms reported by medical students during gross anatomy cadaver dissection

Pietrzyk¹,

Torres²,

Denisow-Pietrzyk³

et al. 2016

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Introduction. Formaldehyde is a noxious gas used as a tissue preservative of cadavers in autopsy rooms. Therefore, exposure to higher concentrations applies particularly to laboratory staff, anatomists and medical students. Prolonged exposure to formaldehyde is associated with clinical complications. Objective. To assess whether exposure to repeated inhalation of low concentrations of formaldehyde (FA) experienced during a gross anatomy course triggers subjective clinical symptoms in medical students. Material and methods. All 198 first-year medical students of the Medical University of Lublin, Poland (28% with allergy history and 72% without allergy history; 69% male and 31% female) responded to a questionnaire concerning their subjective FA-related clinical symptoms. Differences in proportions of experienced symptoms between allergic vs. nonallergic, and female vs. males were compared by the Mann-Whitney U test. Results. Even though formaldehyde concentrations in the gross anatomy laboratory were relatively low (0.47-0.57 mg/m 3 ), medical students experienced various reactions (lacrimation in 85.9%, red eyes, dry and itchy eyes, runny nose, sneezing, and headache in > 50% of students, cough in 44%, and dry throat or throat irritation in 42% of students). Among students with a history of allergy, eye, nose, skin and respiratory system symptoms occurred more frequently in comparison to nonallergic students. Female individuals demonstrated higher sensitivity to FA exposure. Conclusions. Exposure to formaldehyde may result in development of clinical symptoms in medical students. Particularly unpleasant symptoms may be experienced by individuals with allergy history. It is necessary to decrease formaldehyde concentrations in the anatomy dissection laboratory. streszczenie Wprowadzenie. Formaldehyd to szkodliwa substancja chemiczna, której wodny roztwór jest powszechnie stosowany jako środek konserwujący w prosektoriach anatomicznych. Osobami szczególnie narażo-nymi na ekspozycję na formaldehyd są studenci medycyny oraz perFormaldehyde-related clinical symptoms reported by medical students during gross anatomy cadaver dissection subiektywne objawy kliniczne u studentów medycyny związane z ekspozycją na formaldehyd podczas zajęć prosektoryjnych z anatomii

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Formaldehyde-related clinical symptoms reported by medical students during gross anatomy cadaver dissection

Pietrzyk¹,

Torres²,

Denisow-Pietrzyk³

et al. 2016

View full text Add to dashboard Cite

show abstract

“…The irritant action of formaldehyde on eyes, upper respiratory tract and skin is well documented [4,[14][15][16][17][18][19][20]. Our results indicate increased incidence, with a high significance, and relative risk of manifestation of subjective symptoms from the upper respiratory tract, respiratory system and the skin in the group of dental professionals.…”

Section: Discussionsupporting

confidence: 56%

“…The irritant action of formaldehyde on eyes (watery, itchy eyes), upper respiratory tract (itchy, runny, or stuffy nose, sinus fullness, dry or sore throat) and skin (irritation and dermatitis) is well documented [4,[14][15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Health risk assessment of exposure to formaldehyde in dental materials

et al. 2014

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Aldehydes and Acetals

Bernal,

Loccisano,

Neilson

et al. 2023

Patty's Toxicology

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Aldehydes and acetals are both naturally occurring and the result of manufacturing processes, resulting in potential human exposures in occupational settings and from the ambient air and the use of consumer products. Aldehydes and acetals have been identified as genotoxicants, carcinogens, reproductive and developmental toxicants, and irritants. However, many also demonstrate limited toxicological effects at anticipated exposure levels in the general population. Here, 64 aldehydes and acetals are cataloged by sub‐class, chemical and physical properties, toxicological effects, and regulatory standards for occupational and general population cohorts. This summary of selected aldehydes and acetals represents the range of potential toxicological effects, which may cause difficulty in utilizing read‐across to predict the toxicity of aldehydes and acetals without toxicological data.

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Formaldehyde and chemosensory irritation in humans: A controlled human exposure study

Cited by 135 publications

References 51 publications

Formaldehyde-related clinical symptoms reported by medical students during gross anatomy cadaver dissection

Formaldehyde-related clinical symptoms reported by medical students during gross anatomy cadaver dissection

Health risk assessment of exposure to formaldehyde in dental materials

Aldehydes and Acetals

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