Formaldehyde and cancer risk: a quantitative review of cohort studies through 2006

Bosetti, Cristina; McLaughlin, Joseph K.; Tarone, Robert E.; Pira, Enrico; Vecchia, Carlo La

doi:10.1093/annonc/mdm202

Cited by 173 publications

(144 citation statements)

References 37 publications

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“…The only two studies concerning the association between exposure to FA and nasopharyngeal cancer that presented data on exposure to ceiling concentrations obtained higher relative risk values compared with the other studies [1,12,26]. Moreover, other groups also suggested ceiling concentrations as the most important exposure metric, when attempting to define the relative risk of myeloid leukaemia in workers exposed to FA [1,[27][28][29].…”

Section: Discussionmentioning

confidence: 96%

Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production

Viegas¹,

Ladeira²,

Nunes³

et al. 2010

Toxicology Letters

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Background: According to the Report on Carcinogens, formaldehyde ranks 25 th in the overall U.S. chemical production, with more than 5 million tons produced each year. Given its economic importance and widespread use, many people are exposed to formaldehyde environmentally and/or occupationally. Presently, the International Agency for Research on Cancer classifies formaldehyde as carcinogenic to humans (Group 1), based on sufficient evidence in humans and in experimental animals. Manyfold in vitro studies clearly indicated that formaldehyde can induce genotoxic effects in proliferating cultured mammalian cells. Furthermore, some in vivo studies have found changes in epithelial cells and in peripheral blood lymphocytes related to formaldehyde exposure.

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Section: Discussionmentioning

confidence: 96%

Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production

Viegas¹,

Ladeira²,

Nunes³

et al. 2010

Toxicology Letters

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“…Epidemiological studies revealed evidence for the carcinogenicity of formalin and reported that industrial workers who are exposed to formaldehyde or formaldehyde-containing products are at increased risk of nasopharyngeal and hypopharyngeal cancers [17,21,22]. However, there was no association with the highest formaldehyde exposure and lung cancer or leukemia [23,24].…”

mentioning

confidence: 99%

Formaldehyde-related clinical symptoms reported by medical students during gross anatomy cadaver dissection

Pietrzyk¹,

Torres²,

Denisow-Pietrzyk³

et al. 2016

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Introduction. Formaldehyde is a noxious gas used as a tissue preservative of cadavers in autopsy rooms. Therefore, exposure to higher concentrations applies particularly to laboratory staff, anatomists and medical students. Prolonged exposure to formaldehyde is associated with clinical complications. Objective. To assess whether exposure to repeated inhalation of low concentrations of formaldehyde (FA) experienced during a gross anatomy course triggers subjective clinical symptoms in medical students. Material and methods. All 198 first-year medical students of the Medical University of Lublin, Poland (28% with allergy history and 72% without allergy history; 69% male and 31% female) responded to a questionnaire concerning their subjective FA-related clinical symptoms. Differences in proportions of experienced symptoms between allergic vs. nonallergic, and female vs. males were compared by the Mann-Whitney U test. Results. Even though formaldehyde concentrations in the gross anatomy laboratory were relatively low (0.47-0.57 mg/m 3 ), medical students experienced various reactions (lacrimation in 85.9%, red eyes, dry and itchy eyes, runny nose, sneezing, and headache in > 50% of students, cough in 44%, and dry throat or throat irritation in 42% of students). Among students with a history of allergy, eye, nose, skin and respiratory system symptoms occurred more frequently in comparison to nonallergic students. Female individuals demonstrated higher sensitivity to FA exposure. Conclusions. Exposure to formaldehyde may result in development of clinical symptoms in medical students. Particularly unpleasant symptoms may be experienced by individuals with allergy history. It is necessary to decrease formaldehyde concentrations in the anatomy dissection laboratory. streszczenie Wprowadzenie. Formaldehyd to szkodliwa substancja chemiczna, której wodny roztwór jest powszechnie stosowany jako środek konserwujący w prosektoriach anatomicznych. Osobami szczególnie narażo-nymi na ekspozycję na formaldehyd są studenci medycyny oraz perFormaldehyde-related clinical symptoms reported by medical students during gross anatomy cadaver dissection subiektywne objawy kliniczne u studentów medycyny związane z ekspozycją na formaldehyd podczas zajęć prosektoryjnych z anatomii

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“…In addition, formalin contains toxic compounds that have carcinogenic effects [e.g. 6,7], and special care is required to handle samples containing this substance.…”

Section: Open Accessmentioning

confidence: 99%

Cost/benefit and the effect of sample preservation procedures on quantitative patterns in benthic ecology

Souza

Barros

2017

Helgol Mar Res

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Some benthic assemblages studies have tested the effects of different preservation procedures on biomass, but their influence on quantitative patterns (number of species and abundance) is still unclear. We evaluated the influence of two sample preservation procedures on quantitative patterns in benthic ecology. Ten sampling points were systematically interspersed on two types of sediment (sandy and muddy). At each sediment type, samples from five sampling points were fixed in 10% formalin, and the other five points were preserved in 70% ethanol (without previous fixation). Three replicates were collected at each sampling point, and samples were washed in 0.5 mesh size and sorted in laboratory. A cost/benefit analysis was performed considering the washing time in laboratory and the costs of substances. A total of 1970 individuals were collected (muddy sediment: 132; sandy sediment: 1838), belonging to 121 taxa (muddy: 49; sandy: 83). Assemblages preserved in ethanol were composed of 795 individuals and 80 taxa, while those fixed with formalin had 1173 individuals and 94 taxa. Polychaeta predominated as the most abundant group for both preservation procedures. For the whole benthic community, significant differences occurred only between sediment types. Significant differences in the number of individuals of polychaetes were observed for the different preservation procedures in sandy sediment. Ethanol has the best cost/benefit ratio in both sediment types due to additional costs to attend safety requirements for formalin-fixed samples. Further studies should evaluate how quantitative patterns are affected by exposure time of preservation, anesthesia interaction, and morphological deformations (e.g. impossibility of identification).

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Formaldehyde and cancer risk: a quantitative review of cohort studies through 2006

Cited by 173 publications

References 37 publications

Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production

Genotoxic effects in occupational exposure to formaldehyde: A study in anatomy and pathology laboratories and formaldehyde-resins production

Formaldehyde-related clinical symptoms reported by medical students during gross anatomy cadaver dissection

Cost/benefit and the effect of sample preservation procedures on quantitative patterns in benthic ecology

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