Abstract:A formal total synthesis of (−)-aspidophytine
(2), a key substructure associated with the heterodimeric
indole alkaloid
haplophytine (1) and itself a natural product, has been
established by employing the homochiral and enzymatically derived cis-1,2-dihydrocatechol 8 as a starting material.
Specifically, compound 8 has been converted into the
pentacyclic product 26, an advanced intermediate associated
with a previously reported synthesis of aspidophytine (2). Simple modifications to the reaction sequence have … Show more
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