Formal thought disorder in patients with first-episode schizophrenia: Results of a one-year follow-up study

Üçok, Alp; Karakaş, Begum; Şenay, Olcay

doi:10.1016/j.psychres.2021.113972

Cited by 8 publications

(10 citation statements)

References 48 publications

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“…Following on the initial dichotomization of FTD by Fish (see [26] for an overview), factor analytic studies indicate that at least two (positive/disorganisation and negative/impoverishment), if not more [27], separable latent factors may account for these items [28]. Importantly, these factors appear to have distinct trajectories and treatment responsiveness [29,30], making it critical to parse these multiple factors and examine their neural correlates separately (the collapsed dimensions issue).…”

Section: Prior Work On Neuroanatomy Of Ftdmentioning

confidence: 99%

Language Network Dysfunction and Formal Thought Disorder in Schizophrenia

Palaniyappan

Homan

Alonso-Sánchez

2022

Schizophrenia Bulletin

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Background Pathophysiological inquiries into schizophrenia require a consideration of one of its most defining features: disorganization and impoverishment in verbal behavior. This feature, often captured using the term Formal Thought Disorder (FTD), still remains to be one of the most poorly understood and understudied dimensions of schizophrenia. In particular, the large-scale network level dysfunction that contributes to FTD remains obscure to date. Study Design In this narrative review, we consider the various challenges that need to be addressed for us to move towards mapping FTD (construct) to a brain network level account (circuit). Study Results The construct-to-circuit mapping goal is now becoming more plausible than it ever was, given the parallel advent of brain stimulation and the tools providing objective readouts of human speech. Notwithstanding this, several challenges remain to be overcome before we can decisively map the neural basis of FTD. We highlight the need for phenotype refinement, robust experimental designs, informed analytical choices, and present plausible targets in and beyond the Language Network for brain stimulation studies in FTD. Conclusions Developing a therapeutically beneficial pathophysiological model of FTD is a challenging endeavor, but holds the promise of improving interpersonal communication and reducing social disability in schizophrenia. Addressing the issues raised in this review will be a decisive step in this direction.

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Section: Prior Work On Neuroanatomy Of Ftdmentioning

confidence: 99%

Language Network Dysfunction and Formal Thought Disorder in Schizophrenia

Palaniyappan

Homan

Alonso-Sánchez

2022

Schizophrenia Bulletin

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“…SUDs involving cocaine, alcohol, stimulants, hallucinogens, or tobacco are associated with FTD severity 13,66,67 . Another identified limitation is that, even if the search syntax used in the current meta-analysis intended to include all publications on FTD and its subcomponents, FTD is actually a heterogeneous construct which can be expressed using many terms, and whose exact conceptual structure is still being explored using factor analyses of clinical scales 7 . Furthermore, there is a paucity of publications exploring the association between cannabis use and specific FTD subcomponents.…”

Section: Random Effects Model Prediction Intervalmentioning

confidence: 99%

“…At least two dimensions emerge as a consensus: negative FTD, referring to a deficit in speech and thought production; and positive FTD, referring to an increased amount of produced speech. Positive FTD is consistently associated with the disorganization dimension in several models of schizophrenia symptoms 1,7,18 . Previous research in individuals with schizotypal traits reported that the severity of disorganization was higher in cannabis users than in non-users 19 , suggesting that cannabis worsens positive FTD in a non-clinical sample.…”

Section: Introductionmentioning

confidence: 99%

“…FTD is particularly frequent in schizophrenia, as it is found in 27-80% of patients 1 , but it may also occur in other types of disorders such as depression and mania 1,4 . FTD encompasses particularly disabling symptoms that increase social isolation 5 , reduce quality of life 6 and are associated with poorer clinical outcomes 7 . This disorder is predictive of conversion to psychosis in high-risk populations 8 , and is the strongest predictor of conversion from first-episode psychosis to schizophrenia 9 .…”

Section: Introductionmentioning

confidence: 99%

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Association between formal thought disorder and cannabis use: a systematic review and meta-analysis

et al. 2022

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Formal thought disorder (FTD) is a multidimensional syndrome mainly occurring along the psychosis continuum. Cannabis use is known to increase symptoms of psychosis, particularly positive symptoms. However, the impact of cannabis use on FTD in individuals presenting symptoms along the psychosis continuum remains unclear. To address this knowledge gap, we conducted a meta-analysis examining the association between cannabis use and FTD in those individuals. We hypothesized that cannabis would worsen FTD. We conducted a systematic search of the PubMed, ScienceDirect, PsycINFO, Web of Science, Embase and Google Scholar databases up to July 2022. The results were collated through a random-effects model using the statistical software R. Reference lists of included studies were searched for additional relevant publications. Nineteen studies were included, totalling 1840 cannabis users and 3351 non-cannabis users. The severity of FTD was found to be higher in cannabis users (SMD = 0.21, 95%CI [0.12–0.29], p = 0.00009). Subgroup analyses revealed that FTD severity was increased among cannabis users, regardless of the disorder severity: healthy individuals (SMD = 0.19, 95%CI [0.05–0.33], p = 0.02); patients with first-episode psychosis (SMD = 0.21, 95%CI [0.01–0.41], p = 0.04); patients with schizophrenia (SMD = 0.25, 95%CI [0.11–0.38], p = 0.005). Between-group differences were not significant. In line with its already known effect on positive symptoms in psychosis, cannabis use appears to be associated with increased FTD severity all along the psychosis continuum. Future research should consider potential confounding variables such as other substance use disorders and explore how FTD dimensions are impacted by cannabis use.

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“…Following on the initial dichotomization of FTD by Fish (see [22] for an overview), factor analytic studies indicate that at least two (positive/disorganisation and negative/impoverishment), if not more, separable latent factors may account for these items [23]. Importantly, these factors appear to have distinct trajectories and treatment responsiveness [24,25], making it critical to examine their neural correlates separately (the collapsed dimensions issue).…”

Section: Introductionmentioning

confidence: 99%

Language Network Dysfunction and Formal Thought Disorder in schizophrenia

Palaniyappan¹,

Homan²,

Alonso-Sánchez³

2022

Preprint

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BackgroundPathophysiological inquiries into schizophrenia require a consideration of one of its defining features: disorganisation and impoverishment in verbal behaviour. This feature, often captured using the term Formal Thought Disorder, still remains to be one of the most poorly understood and often understudied dimensions of schizophrenia. AimIn this review, we consider the various challenges that need to be addressed for us to move towards mapping FTD (construct) to a brain network level account (circuit). This construct-to-circuit mapping goal is now becoming more plausible than it ever was, given the advent of tools providing objective readouts of human speech. ConclusionsWe suggest that any comprehensive pathophysiological model of schizophrenia must satisfactorily account for the onset and persistence of FTD and address the nature of Language Network dysfunction in this illness. To this end, we consider the need for phenotype refinement, robust experimental designs, informed analytical choices and suggest specific steps that can be taken towards the deciphering the neural mechanisms underwriting FTD, and the translational promise of improved interpersonal communication and reduced social disability.

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Formal thought disorder in patients with first-episode schizophrenia: Results of a one-year follow-up study

Cited by 8 publications

References 48 publications

Language Network Dysfunction and Formal Thought Disorder in Schizophrenia

Language Network Dysfunction and Formal Thought Disorder in Schizophrenia

Association between formal thought disorder and cannabis use: a systematic review and meta-analysis

Language Network Dysfunction and Formal Thought Disorder in schizophrenia

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