Form, shape and function: segmented blood flow in the choriocapillaris

Zouache, Moussa A.; Eames, I.; Klettner, C. A.; Luthert, Philip J.

doi:10.1038/srep35754

Cited by 52 publications

(93 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, our data do not back a generalization for the whole choroid (Nickla & Wallman ; Zouache et al. ). The different diurnal patterns of CCP and SLP compared to MAP, could be due to the size of the vessels in both layers, as they are much smaller than in HL (Esmaeelpour et al.…”

Section: Discussioncontrasting

confidence: 99%

Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography

Siegfried

Rommel

Rothe

et al. 2019

Acta Ophthalmologica

View full text Add to dashboard Cite

Purpose: To investigate diurnal changes of choroidal sublayer perfusion in normal eyes and to identify influencing factors using optical coherence tomography angiography (OCTA). Methods: A prospective study was conducted on healthy volunteers, each of whom underwent repeated measurements of subfoveal choroidal thickness (SFCT) via enhanced depth imaging (EDI) optical coherence tomography (OCT) as well as perfusion of choroidal vascular sublayers using OCTA at 7 a.m., 12 p.m., 4 p.m. and 8 p.m. Possible interactions between diurnal variations and other factors, such as mean arterial pressure (MAP), gender and age, were evaluated. Results: A total of 22 eyes from 22 participants were analysed. Mean age of participants was 56 years. A significant pattern of diurnal variation was observed for SFCT (p < 0.001) as well as perfusion of Sattler's layer (SLP; p = 0.009) and Haller's layer (HLP; p = 0.003). SFCT demonstrated a linear decrease, being thicker in the morning (348 lm) and thinner in the evening (310 lm). Both, SLP and HLP showed a quadratic relation to time of day, increasing from morning (64% and 76%) to afternoon (66% and 77%), before decreasing again in the evening (64% and 76%). HLP changes were significantly associated with fluctuations of MAP (B = 0.0007; CI 0.0001-0.0014; p = 0.047). No significant differences with regard to gender were detectable. However, older participants (≥60 years) had fewer diurnal changes (p = 0.042). Conclusion: Optical coherence tomography angiography-based analysis of choroidal sublayer perfusion demonstrated significant diurnal variations. Therefore, it is important to account for time of day, when comparing longitudinal OCTA data.

show abstract

Section: Discussioncontrasting

confidence: 99%

Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography

Siegfried

Rommel

Rothe

et al. 2019

Acta Ophthalmologica

View full text Add to dashboard Cite

show abstract

“…Histologic publications suggested that this instrument cannot detect the specific morphology of the normal vascular network in the choriocapillaris layer within the macular area 7–9 . We thus evaluated the intensity of the decorrelation signals as the index of blood flow but not the vascular structure per se in the choriocapillaris layer.…”

Section: Methodsmentioning

confidence: 99%

Clinical relevance of reduced decorrelation signals in the diabetic inner choroid on optical coherence tomography angiography

Dodo

Suzuma

Ishihara

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Diabetes induces lesions of the retinal and choroidal capillaries, which promote the pathogenesis of diabetic retinopathy (DR). The decorrelation signals in optical coherence tomography angiography (OCTA) represent the blood flow and vascular structure, and three-dimensional OCTA images enable individual capillary layers to be evaluated separately. The current study documented that en-face OCTA images revealed spots of flow void in the choriocapillaris layer in eyes with DR. Quantitative investigation demonstrated that non-flow areas within the central subfield (CSF) increased in eyes with more severe DR grades. The non-flow areas in the choriocapillaris layer were also associated with poorer visual acuity (VA) in all 108 eyes. A modest correlation was noted between the areas of flow void and poorer VA in 69 eyes without DME, whereas the non-flow areas were not related to VA or to CSF thickness measured by OCT in 39 eyes with DME. In 12 eyes with ischemic maculopathy, the choriocapillaris layer beneath the disrupted ellipsoid zone of the photoreceptor (EZ) had greater areas of flow void than did the area beneath an intact EZ. These data suggested that disrupted choroidal circulation has clinical relevance and contributes to the pathogenesis of DR.

show abstract

“…Both of the long posterior ciliary arteries divide the developing immature choroid along the horizontal meridian, preventing the superior precapillary branches of the short posterior ciliary arteries from connecting with inferior branches across the horizontal meridian. Only at the level of the choroidal capillaries is there a segmental connection across the horizontal meridian [44]. This is in contrast to the rodent's eye, where the superior and inferior hemispheres of the choriocapillaris are clearly separated by the nasal and temporal long posterior ciliary arteries [45].…”

Section: The Impact Of the Choroidal Development On Defining The Horimentioning

confidence: 99%

The Horizontal Raphe of the Human Retina and its Watershed Zones

May

Rutkowski

2019

Vision

View full text Add to dashboard Cite

The horizontal raphe (HR) as a demarcation line dividing the retina and choroid into separate vascular hemispheres is well established, but its development has never been discussed in the context of new findings of the last decades. Although factors for axon guidance are established (e.g., slit-robo pathway, ephrin-protein-receptor pathway) they do not explain HR formation. Early morphological organization, too, fails to establish a HR. The development of the HR is most likely induced by the long posterior ciliary arteries which form a horizontal line prior to retinal organization. The maintenance might then be supported by several biochemical factors. The circulation separate superior and inferior vascular hemispheres communicates across the HR only through their anastomosing capillary beds resulting in watershed zones on either side of the HR. Visual field changes along the HR could clearly be demonstrated in vascular occlusive diseases affecting the optic nerve head, the retina or the choroid. The watershed zone of the HR is ideally protective for central visual acuity in vascular occlusive diseases but can lead to distinct pathological features.

show abstract

Form, shape and function: segmented blood flow in the choriocapillaris

Cited by 52 publications

References 51 publications

Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography

Evaluating diurnal changes in choroidal sublayer perfusion using optical coherence tomography angiography

Clinical relevance of reduced decorrelation signals in the diabetic inner choroid on optical coherence tomography angiography

The Horizontal Raphe of the Human Retina and its Watershed Zones

Contact Info

Product

Resources

About