Forkhead box P3+ T cells express interleukin-17 in nasal mucosa of patients with both allergic rhinitis and polyposis

T, Liu; Song, Chunyan; Am, Liu; Xie, Changsheng; Zhao, Fei; Chen, X; Lv, Cheng; Yang, Ping

doi:10.1111/j.1365-2249.2010.04278.x

Cited by 32 publications

(28 citation statements)

References 22 publications

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“…Treg activation in peripheral blood cells is reported to be reduced in CRS patients compared with control patients, but most studies do not find reduced levels of the suppressive cytokines IL-10 or TGF-β (136–139). Studies in noneosinophilic patients in Asian countries have shown increased presence of IL-17–producing FOXP3 + Tregs (134, 140, 141). On balance, CRS cannot be attributed to defects in Treg responses at present.…”

Section: Innate and Adaptive Inflammatory Responses Underlying The Pamentioning

confidence: 99%

Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis

Schleimer

2017

Annu. Rev. Pathol. Mech. Dis.

386

419

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Chronic rhinosinusitis (CRS) is a troublesome, chronic inflammatory disease that affects over 10% of the adult population, causing decreased quality of life, lost productivity, and lost time at work and leading to more than a million surgical interventions annually worldwide. The nose, paranasal sinuses, and associated lymphoid tissues play important roles in homeostasis and immunity, and CRS significantly impairs these normal functions. Pathogenic mechanisms of CRS have recently become the focus of intense investigations worldwide, and significant progress has been made. The two main forms of CRS that have been long recognized, with and without nasal polyps, are each now known to be heterogeneous, based on underlying mechanism, geographical location, and race. Loss of the immune barrier, including increased permeability of mucosal epithelium and reduced production of important antimicrobial substances and responses, is a common feature of many forms of CRS. One form of CRS with polyps found worldwide is driven by the cytokines IL-5 and IL-13 coming from Th2 cells, type 2 innate lymphoid cells, and probably mast cells. Type 2 cytokines activate inflammatory cells that are implicated in the pathogenic mechanism, including mast cells, basophils, and eosinophils. New classes of biological drugs that block the production or action of these cytokines are making important inroads toward new treatment paradigms in polypoid CRS.

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Section: Innate and Adaptive Inflammatory Responses Underlying The Pamentioning

confidence: 99%

Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis

Schleimer

2017

Annu. Rev. Pathol. Mech. Dis.

386

419

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“…Serum IL-17A levels were higher in the patients with SAR [8,9] and T H 17 cells responded to allergen [10]. IL-17A and T H 2 cytokines enhanced T H 2-driven pathology, which led to more severe disease in a murine model.…”

Section: Introductionmentioning

confidence: 95%

Long-term sublingual immunotherapy for Japanese cedar pollinosis and the levels of IL-17A and complement components 3a and 5a

et al. 2015

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“…Plasma IL-17 levels were higher in the patients with AR and TH17 cells responded to allergen [12][13][14]. However, IL-17 response to SLIT in AR caused by house dust mite remains unclear.…”

Section: Changes In the Clinical Characteristics During 3 Yearsmentioning

confidence: 85%

Cytokine Responses to Specific Immunotherapy in House Dust Mite-Induced Allergic Rhinitis Patients

2015

Inflammation

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Allergen-specific immunotherapy is the only immunomodulatory treatment that may alter the natural course of allergic disease. However, cytokine responses accompanying sublingual immunotherapy (SLIT) responder phenotypes have not been fully understood. Herein, we examined the level of crucial plasma cytokines during SLIT and evaluated whether their changes correlated to symptom scores. We observed that the levels of interleukin (IL)-17 and complement components C3a and C5a as well as IL-4 at year 3 of SLIT were significantly decreased than those at baseline. In contrast, there was no significant difference in the levels of IL-5, IL-13, and interferon (IFN)-γ. Notably, a significant positive correlation was found between the levels of IL-17 and the symptom scores at year 3. These results suggest that IL-17 could be considered a potential biomarker for the therapeutic effect of SLIT in allergic rhinitis caused by house dust mite.

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Forkhead box P3+ T cells express interleukin-17 in nasal mucosa of patients with both allergic rhinitis and polyposis

Cited by 32 publications

References 22 publications

Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis

Immunopathogenesis of Chronic Rhinosinusitis and Nasal Polyposis

Long-term sublingual immunotherapy for Japanese cedar pollinosis and the levels of IL-17A and complement components 3a and 5a

Cytokine Responses to Specific Immunotherapy in House Dust Mite-Induced Allergic Rhinitis Patients

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