Forgotten and novel aspects in pancreas development

Pieler, Tomas; Chen, Yonglong

doi:10.1042/bc20050069

Cited by 32 publications

(28 citation statements)

References 92 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although there have been several recent reviews that have touched on some aspects of Xenopus pancreas development (Blitz et al, 2006; Pieler and Chen, 2006; Spagnoli, 2007; Zorn and Wells, 2007; Pearl and Horb, 2008), none has comprehensively covered pancreas development in Xenopus from gastrulation through metamorphosis. This review aims to give detailed insight into pancreas development in Xenopus laevis from the end of gastrulation, when the endoderm becomes regionalized, through the emergence of pancreatic buds, to the cellular rearrangements that take place at metamorphosis resulting in a mature pancreas.…”

Section: Introductionmentioning

confidence: 99%

Xenopus pancreas development

Pearl

Bilogan

Mukhi

et al. 2009

Developmental Dynamics

View full text Add to dashboard Cite

Understanding how the pancreas develops is vital to finding new treatments for a range of pancreatic diseases, including diabetes and pancreatic cancer. Xenopus is a relatively new model organism for the elucidation of pancreas development, and has already made contributions to the field. Recent studies have shown benefits of using Xenopus for understanding both early patterning and lineage specification aspects of pancreas organogenesis. This review focuses specifically on Xenopus pancreas development, and covers events from the end of gastrulation, when regional specification of the endoderm is occurring, right through metamorphosis, when the mature pancreas is fully formed. We have attempted to cover pancreas development in Xenopus comprehensively enough to assist newcomers to the field and also to enable those studying pancreas development in other model organisms to better place the results from Xenopus research into the context of the field in general and their studies specifically.

show abstract

Section: Introductionmentioning

confidence: 99%

Xenopus pancreas development

Pearl

Bilogan

Mukhi

et al. 2009

Developmental Dynamics

View full text Add to dashboard Cite

show abstract

“…The developmental processes of diaphragm, gut, and its accessory organs such as pancreas, occur from endodermal and mesodermal embryonic layers and this requires a close interaction between numerous signals such as sonic hedgehog (shh) and their key transcription regulators to transform these layers into distinct sets of precursor cells and specific developed structures [10–12]. Shh, which is expressed from notochord, has been shown to play a pivotal role in formation and differentiation of the gut and its accessory organs [12, 13].…”

Section: Discussionmentioning

confidence: 99%

A Triad of Congenital Diaphragmatic Hernia, Meckel’s Diverticulum, and Heterotopic Pancreas

Mandhan

Saied

Ali

2014

Case Reports in Pediatrics

View full text Add to dashboard Cite

Congenital diaphragmatic hernia is a common developmental anomaly encountered by paediatric surgeons. It is known to be associated with extradiaphragmatic malformations, which include cardiac, renal, genital, and chromosomal abnormalities. Herein, we report a newborn born with concurrent congenital diaphragmatic hernia, Meckel's diverticulum, and heterotopic pancreatic tissue. This is the first case report of such a triad with description of possible mechanisms of the development.

show abstract

“…They may participate in the removal of mannose-6-phosphatebearing ligands during secretory granule maturation. However, as the endocrine portion represents less than 2% of the total mass of the adult mammalian pancreas [Pieler and Chen, 2006], one could speculate that the increase in MPRs observed during pancreatic development is due to an increase in exocrine cells in the organ. In the spleen, thymus and kidney, the activity of ␤ Nag and ␣ Man did not show a clear tendency during development and, as with the other organs, a correlation with MPR expression was not found.…”

Section: Discussionmentioning

confidence: 99%

Organ-Specific Changes in the Expression of Mannose-6-Phosphate Receptors during Postnatal Development in Rats

Jofré¹,

Balmaceda²,

Sartor³

et al. 2008

Cells Tissues Organs

View full text Add to dashboard Cite

The significance of the coexistence of 2 mannose-6-phosphate receptors (MPRs) in most cell types still remains poorly understood. In this study, expression of the cation-dependent MPR (CD-MPR) and the cation-independent MPR (CI-MPR) was measured by Western blot in rat organs at 3 ages, i.e. in newborn and 10- and 90-day-old rats. It was observed that expression of the CI-MPR tends to diminish from newborns to adults in 5 of the 6 organs studied, whereas the CD-MPR did not show a clear tendency over time. In pancreas, conversely, both MPRs increased progressively from newborns to adults. The activity of 2 acid hydrolases was also measured at the different ages, and a low correlation was found with the expression of the 2 MPRs. With the exception of the pancreas, it is possible that the CI-MPR is mostly occupied with the clearance of insulin-like growth factor-II at early stages of development, and that later both MPRs may participate in the maturation of the lysosomal apparatus. We propose that in the pancreas, both receptors may be involved in increasing the proteolytic activity of this exocrine gland during postnatal development.

show abstract

Forgotten and novel aspects in pancreas development

Cited by 32 publications

References 92 publications

Xenopus pancreas development

Xenopus pancreas development

A Triad of Congenital Diaphragmatic Hernia, Meckel’s Diverticulum, and Heterotopic Pancreas

Organ-Specific Changes in the Expression of Mannose-6-Phosphate Receptors during Postnatal Development in Rats

Contact Info

Product

Resources

About