Foreword

Feigl, F.

doi:10.1016/b978-0-444-40209-7.50004-x

Cited by 44 publications

(53 citation statements)

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“…The methanol assay [9] consisted of oxidizing the methanol to formaldehyde and quantitating the violet color formed on the addition of chromotropic acid.…”

Section: Potential Ester Bondsmentioning

confidence: 99%

Interchain crosslinks in the entomocidal bacillus thuringiensis protein crystal

Dastidar¹,

Nickerson²

1979

FEBS Letters

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“…The methanol assay [9] consisted of oxidizing the methanol to formaldehyde and quantitating the violet color formed on the addition of chromotropic acid.…”

Section: Potential Ester Bondsmentioning

confidence: 99%

Interchain crosslinks in the entomocidal bacillus thuringiensis protein crystal

Dastidar¹,

Nickerson²

1979

FEBS Letters

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“…The reaction were equilibrated at 303 K for 24 h. The results of estimation of unreacted NCS indicated 1:1 stoichiometry i.e., one mole of doxycycline hydrochloride consumed one mole of NCS. The main product of DOX oxidation, 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,4,11-trioxotetracene-2-carboxamide is identified by the spot tests [17]. Further, the oxidation product was confirmed by LC-MS spectral analysis.…”

Section: Methodsmentioning

confidence: 70%

Spectroscopic Study on Kinetics of Oxidation of Doxycycline Hydrochloride by N-Chlorosuccinamide in Acidic Medium

Shastry¹,

Asha²,

Sateesh³

2017

Asian J. Chem.

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A tetracycline antibiotic doxycycline hydrochloride (DOX) has been oxidized by N-chlorosuccinamide (NCS) in sulphuric acid medium at 303 K and the kinetics have been investigated. The stoichiometry of the reaction was found to be 1:1 where one mole doxycycline reacted with one mole of NCS and the product of oxidation of doxycycline, 1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,4,11-trioxotetracene-2-carboxamide is identified by the spot tests and confirmed by LC-MS spectral analysis. The titled reaction exhibited first-order kinetics with reference to concentration of NCS and doxycycline a fractional order kinetics was observed with respect to [H2SO4] and doxycycline. The changes in the reaction rate on the addition of halide ions and reduction product was studied. The influence of added product, p-toluene sulfonamide was studied and found no significant effect. The influence of ionic strength (NaClO4) and dielectric constant of the medium was investigated on the reaction rate. All the experimental values were compiled together and a mechanism was proposed. The temperature effect was studied for calculating the activation parameters with reference to the rate determining step in the mechanism and the thermodynamic parameters were also discussed.

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“…The proposed mechanism is further supported by the analysis of the products. CO 2 and formaldehyde were detected by the sodium hydroxide solution and spot tests, respectively [19,20]. Another EDTA oxidation product, i.e.…”

Section: Preparation and Characterisation Of Colloidal Mno 2 By The Omentioning

confidence: 99%